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Karyopherin Dysfunction Is a Key Driver of Aging. [PDF]

Aging Cell
Studies on the proteostasis network and aging have focused on protein synthesis, folding, and turnover. Here, emphasis on the spatial dimension in proteostasis is proposed by recognizing nucleocytoplasmic transport as an important player in aging. ABSTRACT Aging is often framed as the gradual erosion of proteostasis, driven by declining chaperone ...
Lapierre LR.
europepmc   +3 more sources

Ibetazol, a novel inhibitor of importin β1-mediated nuclear import [PDF]

Communications Biology
Nucleocytoplasmatic transport plays an essential role in eukaryotic cell homeostasis and is mediated by karyopherins. Importin β1 (KPNB1) and its adaptor protein importin α1 (KPNA2) are the best-characterized karyopherins that effect nuclear import. Here,
Thomas Vercruysse, Els Vanstreels, Maarten Jacquemyn, Sandro Boland, Amuri Kilonda, Sara Allasia, Ilse Vandecaetsbeek, Hugo Klaassen, Matthias Versele, Patrick Chaltin, Arnaud Marchand, Dirk Daelemans   +11 more
doaj   +3 more sources

Importin 7 mediates the nuclear import of HIV-1 integrase via a specific interacting interface. [PDF]

FEBS Open Bio
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Bana J, Yariv A, Oppenheim T, Amartely H, Reichmann D, Livnah O.   +5 more
europepmc   +2 more sources

Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9. [PDF]

Adv Sci (Weinh)
In this study, we demonstrate that Zdhhc17, acting as a PAT, suppresses neuronal apoptosis and promotes axon regeneration after injury, thereby enhancing functional recovery following SCI. In this context, Kpna2 and Ipo9 serve as novel palmitoylation substrates of Zdhhc17, whose palmitoylation prevents the injury‐induced degradation of their proteins ...
Chen M, Chen H, Ding S, Liu F, Zheng X, Wang Y, Tian R, Li H, Liu P, Hu L, Liu B, Rong L, Li M.   +12 more
europepmc   +2 more sources

Nuclear transport proteins: structure, function and disease relevance [PDF]

Signal Transduction and Targeted Therapy, 2023
Proper subcellular localization is crucial for the functioning of biomacromolecules, including proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the localization of many macromolecules within the nuclear or cytoplasmic
Yang Yang, Lu Guo, Lin Chen, Bo Gong, Da Jia, Qingxiang Sun   +5 more
doaj   +2 more sources

Nuclear–Cytoplasmic Shuttling of the Usher Syndrome 1G Protein SANS Differs from Its Paralog ANKS4B [PDF]

Cells
The USH1G protein SANS is a small multifunctional scaffold protein. It is involved in several different cellular processes, such as intracellular transport, in the cytoplasm, or splicing of pre-mRNA, in the cell nucleus.
Jacques S. Fritze, Felizitas F. Stiehler, Uwe Wolfrum   +2 more
doaj   +2 more sources

Ran modulates allosteric crosstalk between importin β surfaces [PDF]

Nature Communications
A cellular gradient of the GTPase Ran orchestrates the movement of import and export complexes through the Nuclear Pore Complex (NPC). Ran-GTP modulates two essential activities of importin β during nuclear import. On the one hand, it reduces the avidity
Ying-Hui Ko, Fenglin Li, Stephanie S. Suinn, Junwei Li, Chun-Feng David Hou, Ravi K. Lokareddy, Gino Cingolani   +6 more
doaj   +2 more sources

Accumulation of TDP-43 causes karyopherin-α4 pathology that characterises amyotrophic lateral sclerosis [PDF]

Frontiers in Neuroscience
Cytoplasmic mislocalisation and nuclear depletion of TDP-43 are pathological hallmarks of amyotrophic lateral sclerosis (ALS), including mutations in the C9ORF72 gene that characterise the most common genetic form of ALS (C9ALS).
Manpreet Singh Atwal, Jerneja Nimac, Jerneja Nimac, Urša Čerček, Urša Čerček, Sarah Ricarda Goesch, Hannah Rebecca Goesch, Paraskevi Tziortzouda, Tiziana Ercolani, Anna Zatorska, Terouz Pasha, Ivo Carre, Jacqueline Mitchell, Claire Troakes, Bart Tummers, Vera Župunski, Boris Rogelj, Boris Rogelj, Tibor Hortobágyi, Tibor Hortobágyi, Frank Hirth   +20 more
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Yeast 26S proteasome nuclear import is coupled to nucleus-specific degradation of the karyopherin adaptor protein Sts1 [PDF]

Scientific Reports
In eukaryotes, the ubiquitin–proteasome system is an essential pathway for protein degradation and cellular homeostasis. 26S proteasomes concentrate in the nucleus of budding yeast Saccharomyces cerevisiae due to the essential import adaptor protein Sts1
Carolyn Allain Breckel, Zane M. Johnson, Christopher M. Hickey, Mark Hochstrasser   +3 more
doaj   +2 more sources

HOX Protein Activity Regulation by Cellular Localization

Journal of Developmental Biology, 2021
While the functions of HOX genes have been and remain extensively studied in distinct model organisms from flies to mice, the molecular biology of HOX proteins remains poorly documented.
Laure Bridoux, Françoise Gofflot, René Rezsohazy   +2 more
doaj   +1 more source