Yeast 26S proteasome nuclear import is coupled to nucleus-specific degradation of the karyopherin adaptor protein Sts1 [PDF]
Scientific ReportsIn eukaryotes, the ubiquitin–proteasome system is an essential pathway for protein degradation and cellular homeostasis. 26S proteasomes concentrate in the nucleus of budding yeast Saccharomyces cerevisiae due to the essential import adaptor protein Sts1
Carolyn Allain Breckel +3 more
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Accumulation of TDP-43 causes karyopherin-α4 pathology that characterises amyotrophic lateral sclerosis [PDF]
Frontiers in NeuroscienceCytoplasmic mislocalisation and nuclear depletion of TDP-43 are pathological hallmarks of amyotrophic lateral sclerosis (ALS), including mutations in the C9ORF72 gene that characterise the most common genetic form of ALS (C9ALS).
Manpreet Singh Atwal +20 more
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Identification of karyopherin α1 and α7 interacting proteins in porcine tissue. [PDF]
PLoS ONE, 2012 Specialized trafficking systems in eukaryotic cells serve a critical role in partitioning intracellular proteins between the nucleus and cytoplasm. Cytoplasmic proteins (including chromatin remodeling enzymes and transcription factors) must gain access ...
Ki-Eun Park +5 more
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Canine soft tissue sarcomas: the expression of RUNX2 and karyopherin alpha-2 in extraskeletal (soft tissues) and skeletal osteosarcomas [PDF]
Frontiers in Veterinary ScienceExtraskeletal osteosarcoma (EOS) is a malignant tumor producing bone matrix and/or chondroid material, without direct attachment to bone or periosteum.
Leonardo Leonardi +3 more
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Transportin-1: A Nuclear Import Receptor with Moonlighting Functions
Frontiers in Molecular Biosciences, 2021 Transportin-1 (Trn1), also known as karyopherin-β2 (Kapβ2), is probably the best-characterized nuclear import receptor of the karyopherin-β family after Importin-β, but certain aspects of its functions in cells are still puzzling or are just recently ...
Allegra Mboukou +5 more
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Ebolavirus Species-Specific Interferon Antagonism Mediated by VP24
Viruses, 2023 Members of the Ebolavirus genus demonstrate a marked differences in pathogenicity in humans with Ebola (EBOV) being the most pathogenic, Bundibugyo (BDBV) less pathogenic, and Reston (RESTV) is not known to cause a disease in humans.
Palaniappan Ramanathan +11 more
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The Ebola Virus Interferon Antagonist VP24 Undergoes Active Nucleocytoplasmic Trafficking
Viruses, 2021 Viral interferon (IFN) antagonist proteins mediate evasion of IFN-mediated innate immunity and are often multifunctional, with distinct roles in viral replication.
Angela R. Harrison +3 more
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Biobanking efforts and new advances in male fertility preservation for rare and endangered species
Asian Journal of Andrology, 2015 Understanding and sustaining biodiversity is a multi-disciplinary science that benefits highly from the creation of organized and accessible collections of biomaterials (Genome Resource Banks).
Pierre Comizzoli
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Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone
eLife, 2019 We report the crystal structure of nuclear import receptor Importin-9 bound to its cargo, the histones H2A-H2B. Importin-9 wraps around the core, globular region of H2A-H2B to form an extensive interface.
Abhilash Padavannil +9 more
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Tumor Biology, 2017 This study aimed to determine whether serum karyopherin alpha 2 levels can be used as a diagnostic biomarker for epithelial ovarian carcinoma. Karyopherin alpha 2 protein was detected by enzyme-linked immunosorbent assay in serum samples from 162 ...
Long Huang +6 more
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