Results 41 to 50 of about 5,815 (206)
Karyopherins play the field [PDF]
The Journal of Cell Biology, 2006 ![][1] Import of proteins (green) into the nucleus is slower than expected, revealing that karyopherins are choosy about their cargo. Proteins that shuttle molecules into the nucleus face the same problem as customers of a dating service.
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Karyopherin α 3 and Karyopherin α 4 Proteins Mediate the Nuclear Import of Methyl-CpG Binding Protein 2 [PDF]
Journal of Biological Chemistry, 2015 Methyl-CpG binding protein 2 (MeCP2) is a nuclear protein with important roles in regulating chromatin structure and gene expression, and mutations in MECP2 cause Rett syndrome (RTT). Within the MeCP2 protein sequence, the nuclear localization signal (NLS) is reported to reside between amino acids 255-271, and certain RTT-causing mutations overlap with
Steven Andrew, Baker +2 more
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Asian Journal of Andrology, 2015 In this experimental prospective study, we aimed to analyze the effect of transient scrotal hyperthermia on the male reproductive organs, from the perspective of sperm parameters, semen plasma biochemical markers, and oxidative stress, to evaluate ...
Meng Rao +6 more
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The paternal genome and the health of the assisted reproductive technology child
Asian Journal of Andrology, 2015 As a number of children born by assisted reproductive technology (ART) are increasing each year across the developed world, the health of such offspring is a matter of public concern.
Sheena EM Lewis, Kishlay Kumar
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Redox regulation of mammalian sperm capacitation
Asian Journal of Andrology, 2015 Capacitation is a series of morphological and metabolic changes necessary for the spermatozoon to achieve fertilizing ability. One of the earlier happenings during mammalian sperm capacitation is the production of reactive oxygen species (ROS) that will ...
Cristian O′Flaherty
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ROS-mediated DJ-1 monomerization modulates intracellular trafficking involving Karyopherin-2
, 2014 Mutations in DJ-1 are a cause of recessive, early-onset Parkinson's disease (PD). Although oxidative stress and mitochondrial integrity have been implicated in PD, it is largely unknown why neurons degenerate.
Larsen, J.P. +11 more
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Karyopherins in the Remodeling of Extracellular Matrix: Implications in Tendon Injury
Journal of Orthopaedics and Sports Medicine, 2023 Rotator Cuff Tendinopathies (RCT) are debilitating conditions characterized by alterations in the extracellular matrix (ECM) of the shoulder tendon, resulting in pain, discomfort, and functional limitations. Specific mediators, including HIF-1α, TGF-β, MMP-9 and others have been implicated in the morphological changes observed in the tendon ECM.
Connor, Diaz +2 more
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Behavioral mechanisms of mammalian sperm guidance
Asian Journal of Andrology, 2015 In mammals, sperm guidance in the oviduct appears essential for successful sperm arrival at the oocyte. Hitherto, three different potential sperm guidance mechanisms have been recognized: thermotaxis, rheotaxis, and chemotaxis, each of them using ...
Serafín Pérez Cerezales +2 more
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Dissecting in vivo steady-state dynamics of karyopherin-dependent nuclear transport [PDF]
, 2016 Karyopherin-dependent molecular transport through the nuclear pore complex is maintained by constant recycling pathways of karyopherins coupled with the Ran-dependent cargo catch-and-release mechanism.
Kumeta, Masahiro +4 more
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Asian Journal of Andrology, 2015 One of the most common lesions present in the spermatozoa of human infertility patients is an idiopathic failure of sperm-egg recognition. Although this unique cellular interaction can now be readily by-passed by assisted reproductive strategies such as ...
Brett Nixon +5 more
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