Results 41 to 50 of about 6,082 (161)
Varicocele and testicular function
Asian Journal of Andrology, 2015 Testicular varicocele, a dilation of the veins of the pampiniform plexus thought to increase testicular temperature via venous congestion, is commonly associated with male infertility.
Alexander W Pastuszak, Run Wang
doaj +1 more source
Animal Research and One Health, EarlyView.Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu +8 more
wiley +1 more source
Karyopherin α2: a control step of glucose-sensitive gene expression in hepatic cells
, 2002 International audienceGlucose is required for an efficient expression of the glucose transporter GLUT2 and other genes. We have shown previously that the intracytoplasmic loop of GLUT2 can divert a signal, resulting in the stimulation of glucose ...
Loizeau, Martine +6 more
core +1 more source
Antagonism of STAT3 signalling by Ebola virus.
PLoS Pathogens, 2021 Many viruses target signal transducers and activators of transcription (STAT) 1 and 2 to antagonise antiviral interferon signalling, but targeting of signalling by other STATs/cytokines, including STAT3/interleukin 6 that regulate processes important to ...
Angela R Harrison +8 more
doaj +1 more source
ΔNp63 Regulates Radioresistance in Human Head and Neck Squamous Carcinoma Cells
Current Issues in Molecular Biology, 2023 Radiation therapy is commonly used to treat head and neck squamous cell carcinoma (HNSCC); however, recurrence results from the development of radioresistant cancer cells.
Kota Sato +4 more
doaj +1 more source
Andrology, EarlyView.ABSTRACT Background Pro‐inflammatory cytokines, TNF and IL‐1B, are essential for testicular homeostasis. Diacerein, an anti‐inflammatory drug, inhibits these cytokines, impairing M2 macrophages and Leydig cells (LCs). However, its impact on Sertoli cells (SCs) and M1 (CD68) macrophages remains unknown.
Elide Loise Freitas de Jesus +6 more
wiley +1 more source
RNA‐Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities
MedComm, Volume 7, Issue 9, September 2026.RNA‐binding proteins (RBPs) regulate RNA stability, localization, translation, and splicing through intrinsic binding domains and interactions with diverse cellular partners. Their competitive and cooperative networks shape disease‐related RNA programs, especially in cancer.
Ling Li, Xiuli Yan, Qing Ji, Hui Zhang
wiley +1 more source
Dissecting in vivo steady-state dynamics of karyopherin-dependent nuclear transport [PDF]
, 2016 Karyopherin-dependent molecular transport through the nuclear pore complex is maintained by constant recycling pathways of karyopherins coupled with the Ran-dependent cargo catch-and-release mechanism.
Kumeta, Masahiro +4 more
core +1 more source
Structural basis for nuclear import of adeno-associated virus serotype 6 capsid protein
Journal of VirologyAdeno-associated viruses (AAVs) are the most extensively researched viral vectors for gene therapy globally. The AAV viral protein 1 (VP1) N-terminus controls the capsid’s ability to translocate into the cell nucleus; however, the exact mechanism of this
Mikayla Hoad +5 more
doaj +1 more source
Ezrin: a regulator of actin microfilaments in cell junctions of the rat testis
Asian Journal of Andrology, 2015 Ezrin, radixin, moesin and merlin (ERM) proteins are highly homologous actin-binding proteins that share extensive sequence similarity with each other.
N Ece Gungor-Ordueri +2 more
doaj +1 more source