Results 41 to 50 of about 9,891 (213)
Importins/Karyopherins Meet Nucleoporins [PDF]
Cell, 1996 I thank Gunter Blobel, Valerie Doye, Dirk Gorlich, Iain Mattaj, Ulf Nehrbass, and Uli Scheer for helpful comments on the manuscript.
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Evidence for an evolutionary relationship between the large adaptor nucleoporin Nup192 and karyopherins [PDF]
, 2014 Nucleocytoplasmic transport is facilitated by nuclear pore complexes (NPCs), which are massive proteinaceous transport channels embedded in the nuclear envelope.
Collins, Leslie N. +4 more
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Karyopherins play the field [PDF]
The Journal of Cell Biology, 2006 ![][1] Import of proteins (green) into the nucleus is slower than expected, revealing that karyopherins are choosy about their cargo. Proteins that shuttle molecules into the nucleus face the same problem as customers of a dating service.
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Modulation of Histone Deposition by the Karyopherin Kap114 [PDF]
Molecular and Cellular Biology, 2005 The nuclear import of histones is a prerequisite for the downstream deposition of histones to form chromatin. However, the coordinate regulation of these processes remains poorly understood. Here we demonstrate that Kap114p, the primary karyopherin/importin responsible for the nuclear import of histones H2A and H2B, modulates the deposition of histones
Nima, Mosammaparast +2 more
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Elucidation of the ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host-cell protein function [PDF]
, 2014 Viral pathogenesis in the infected cell is a balance between antiviral responses and subversion of host-cell processes. Many viral proteins specifically interact with host-cell proteins to promote virus biology.
Altamirano A. A. +41 more
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A Role for the Karyopherin Kap123p in Microtubule Stability [PDF]
Traffic, 2009 Several components of the nuclear transport machinery play a role in mitotic spindle assembly in higher eukaryotes. To further investigate the role of this family of proteins in microtubule function, we screened for mutations in Saccharomyces cerevisiae that confer sensitivity to microtubule‐destabilizing drugs.
Christopher, Ptak +7 more
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Importin-beta and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function [PDF]
, 2017 Protein conjugation with small ubiquitin-related modifier (SUMO) is a post-translational modification that modulates protein interactions and localisation.
Damizia, Michela +7 more
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Inhibition of NUPR1–Karyopherin β1 Binding Increases Anticancer Drug Sensitivity [PDF]
International Journal of Molecular Sciences, 2021 Background: Nuclear protein-1 (NUPR1, also known as p8/Com-1) is a transcription factor involved in the regulation of cellular stress responses, including serum starvation and drug stimulation. Methods: We investigated the mechanism of NUPR1 nuclear translocation involving karyopherin β1 (KPNB1), using a single-molecule binding assay and confocal ...
Chanhee Park +6 more
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Asian Journal of Andrology, 2015 In this experimental prospective study, we aimed to analyze the effect of transient scrotal hyperthermia on the male reproductive organs, from the perspective of sperm parameters, semen plasma biochemical markers, and oxidative stress, to evaluate ...
Meng Rao +6 more
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The paternal genome and the health of the assisted reproductive technology child
Asian Journal of Andrology, 2015 As a number of children born by assisted reproductive technology (ART) are increasing each year across the developed world, the health of such offspring is a matter of public concern.
Sheena EM Lewis, Kishlay Kumar
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