Results 61 to 70 of about 5,815 (206)
Andrology, EarlyView.ABSTRACT Background Pro‐inflammatory cytokines, TNF and IL‐1B, are essential for testicular homeostasis. Diacerein, an anti‐inflammatory drug, inhibits these cytokines, impairing M2 macrophages and Leydig cells (LCs). However, its impact on Sertoli cells (SCs) and M1 (CD68) macrophages remains unknown.
Elide Loise Freitas de Jesus +6 more
wiley +1 more source
Nonstructural protein 5A of hepatitis C virus inhibits the function of karyopherin beta 3
, 2019 It has been suggested that nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) plays a role in the incapacitation of interferon by inactivation of RNA-dependent protein kinase PKR.
Hahm, B +8 more
core +1 more source
Recognition of nuclear targeting signals by Karyopherin-β proteins [PDF]
Current Opinion in Structural Biology, 2010 The Karyopherin-β family of nuclear transport factors mediates the majority of nucleocytoplasmic transport. Although each of the 19 Karyopherin-βs transports unique sets of cargos, only three classes of nuclear localization and export signals, or NLSs and NESs, have been characterized. The short basic classical-NLS was first discovered in the 1980s and
Darui, Xu +2 more
openaire +2 more sources
Resolving conformational changes in FG nucleoporins due to multivalent Karyopherin binding [PDF]
, 2015 The nuclear pore complex (NPC) is a huge macromolecular assembly that selectively regulates the exchange of cargo between the nuclear and the cytoplasmic compartment in a cell.
Schoch, Rafael L.
core +1 more source
Cloning and characterization of the tomato karyopherin α1 gene promoter [PDF]
Development, Growth & Differentiation, 2004 The karyopherin α1 (LeKAPα 1) gene of tomato (Lycopersicon esculentum) encodes a receptor involved in nuclear import. To analyze the expression pattern of this gene, a genomic clone containing its upstream region was isolated and sequenced. To study the promoter functionality, a 2170 bp fragment (LM1), was fused to glucuronidase (GUS) and introduced ...
Liat, Mizrachy +5 more
openaire +2 more sources
Structural basis for nuclear import of adeno-associated virus serotype 6 capsid protein
Journal of VirologyAdeno-associated viruses (AAVs) are the most extensively researched viral vectors for gene therapy globally. The AAV viral protein 1 (VP1) N-terminus controls the capsid’s ability to translocate into the cell nucleus; however, the exact mechanism of this
Mikayla Hoad +5 more
doaj +1 more source
Ezrin: a regulator of actin microfilaments in cell junctions of the rat testis
Asian Journal of Andrology, 2015 Ezrin, radixin, moesin and merlin (ERM) proteins are highly homologous actin-binding proteins that share extensive sequence similarity with each other.
N Ece Gungor-Ordueri +2 more
doaj +1 more source
Comprehensive Physiology, Volume 16, Issue 3, June 2026.This review summarizes how extracellular vesicles from diverse pulmonary and extrapulmonary sources contribute to endothelial dysfunction in ARDS and evaluates emerging endothelial‐targeted therapies for their potential to mitigate EV‐mediated pathogenic mechanisms.
Mohammed Yaman Al Matni +3 more
wiley +1 more source
Identifying a novel region in the Tembusu virus NS5 protein antagonizing type I interferon signaling
Journal of VirologyNumerous species in the genus Flavivirus have been identified to pose serious threats to public health. Most of them have developed evasion strategies to counteract antiviral activity triggered by type I interferon (IFN-I), making prevention and control ...
Ji Zhang +13 more
doaj +1 more source
Asian Journal of Andrology, 2015 Importin proteins were originally characterized for their central role in protein transport through the nuclear pores, the only intracellular entry to the nucleus.
Kate L. Loveland +5 more
doaj +1 more source