Results 71 to 80 of about 6,082 (161)

Nuclear Import of Yeast Proteasomes

Cells, 2015
Proteasomes are highly conserved protease complexes responsible for the degradation of aberrant and short-lived proteins. In highly proliferating yeast and mammalian cells, proteasomes are predominantly nuclear.
Julianne Burcoglu, Liang Zhao, Cordula Enenkel   +2 more
doaj   +1 more source

Controlling the Gatekeeper: Therapeutic Targeting of Nuclear Transport

Cells, 2018
Nuclear transport receptors of the karyopherin superfamily of proteins transport macromolecules from one compartment to the other and are critical for both cell physiology and pathophysiology.
Friederike K. Kosyna, Reinhard Depping
doaj   +1 more source

Extracellular Vesicles as Drivers of Lung Endothelial Dysfunction in ARDS: Mechanisms and Therapeutic Opportunities

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
This review summarizes how extracellular vesicles from diverse pulmonary and extrapulmonary sources contribute to endothelial dysfunction in ARDS and evaluates emerging endothelial‐targeted therapies for their potential to mitigate EV‐mediated pathogenic mechanisms.
Mohammed Yaman Al Matni, Patrick Belvitch, Steven M. Dudek, Eleftheria Letsiou   +3 more
wiley   +1 more source

Regulation of Immune Checkpoints: From Molecular Mechanisms to Clinical Therapies

MedComm, Volume 7, Issue 6, June 2026.
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by unleashing antitumor immunity. This review comprehensively examines the molecular mechanisms underlying key immune checkpoints—including PD‐1/PD‐L1, CTLA‐4, and TIM‐3—and their clinical applications.
Qintao Ge, Liu Yu, Jiahe Lu, Aihetaimujiang Anwaier, Xiyue Xiao, Yonghao Chen, Dingwei Ye, Hailiang Zhang, Wenhao Xu, Wenbin Dai   +9 more
wiley   +1 more source

Sensing and Filtering Environmental Fluctuations: The Case of Biomolecular Condensates in Plants

Advanced Science, Volume 13, Issue 27, 13 May 2026.
The diversity of plant condensates reflects constraints of sessile organisms to coordinate postembryonic development with environmental adaptation. This review examines how plants employ condensates to integrate temperature, light, redox, and nutrient signals.
Panagiotis N. Moschou, Dorothee Staiger
wiley   +1 more source

A karyopherin acts in localized protein synthesis [PDF]

, 2010
Multiple mechanisms are in place to regulate adequate synthesis of proteins, ranging from ways to ensure sequence fidelity, polypeptide folding and protein modification, to control of amounts and subcellular localization of the molecules.
Veenhoff, Liesbeth M.,, Poolman, Bert,, Meinema, Anne C.,, Veenhoff, Liesbeth M.; id_orcid, Meinema, Anne C., Anne C. Meinema, Bert Poolman, Liesbeth M. Veenhoff, Veenhoff, Liesbeth M., Poolman, Bert   +9 more
core   +2 more sources

Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal.

, 2002
peer reviewedThe activation of the pleomorphic adenoma gene 1 (PLAG1) is the most frequent gain-of-function mutation found in pleomorphic adenomas of the salivary glands.
Braem, Caroline V, Van De Ven, Wim J M, Debiec-Rychter, Maria, Maria Debiec-Rychter, Marianne L. Voz, Kas, Koen, Meyen, Eva, Koen Kas, Wim J. M. Van de Ven, Eva Meyen, Caroline V. Braem, Voz, Marianne   +11 more
core   +1 more source

Elucidation of the binding interaction interface between AAV serotype 11 capsid protein and host nuclear import proteins

Molecular Therapy: Methods & Clinical Development
Adeno-associated viruses (AAVs) are widely acknowledged as versatile vectors for gene therapy due to their non-pathogenic nature, inherent capacity for tissue-specific targeting, and their potential for customizable engineering. The N terminus of the AAV
Mikayla Hoad, Sepehr Nematollahzadeh, Justin A. Roby, Gualtiero Alvisi, Jade K. Forwood   +4 more
doaj   +1 more source

Structure and expression of Xenopus karyopherin-beta 3: definition of a novel synexpression group related to ribosome biogenesis

, 2000
Karyopherin-beta 3 is a nuclear transport receptor that appears to be involved in nuclear import of ribosomal proteins. Here we report on sequence and expression of karyopherin-beta 3 in Xenopus.
Chen, Y. L., Solter, M., Wischnewski, J., Pieler, T., Hollemann, T.   +4 more
core   +1 more source

Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of β-catenin [PDF]

, 1998
Background: Control of the nuclear localization of specific proteins is an important mechanism for regulating many signal transduction pathways. Upon activation of the Wnt signaling pathway, β-catenin localizes into the nucleus and interacts with TCF/LEF-
Gumbiner, Barry M., François Fagotto, Barry M. Gumbiner, Ursula Glück, Fagotto, F. ; https://orcid.org/, Glück, U., Glück, Ursula, Gumbiner, B., Fagotto, François   +8 more
core   +1 more source