Results 71 to 80 of about 9,891 (213)

Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. [PDF]

, 2007
Members of the epidermal growth factor receptor family (EGFR/ERBB1, ERBB2/HER2, ERBB3/HER3 and ERBB4/HER4) are key targets for inhibition in cancer therapy.
Bose, Ron, Cole, Philip A, Jura, Natalia, Kuriyan, John, Pickin, Kerry A, Zhang, Xuewu   +5 more
core   +1 more source

TMEM106C, BSG, COPE, CDCA8, KPNA2, LIG1, UQCRH, and CCT5: Predictive of Survival and Immunotherapy Resistance in Hepatocellular Carcinoma

Human Mutation, Volume 2026, Issue 1, 2026.
Introduction Hepatocellular carcinoma (HCC) remains a leading cause of cancer‐related mortality worldwide, with cellular senescence playing a context‐dependent role in tumor progression and the immunosuppressive microenvironment. This study is aimed at identifying senescence‐related gene signatures through integrated single‐cell and transcriptomic ...
Kai Yu, Minqi Chen, Wanchao Hou, Jinhua Lu, Qianhan Liu, Wanrong Zeng, Zhengcai Du, Xiaotao Hou, Erwei Hao, Jiagang Deng, Peipei Gong   +10 more
wiley   +1 more source

Structural basis for nuclear import of adeno-associated virus serotype 6 capsid protein

Journal of Virology
Adeno-associated viruses (AAVs) are the most extensively researched viral vectors for gene therapy globally. The AAV viral protein 1 (VP1) N-terminus controls the capsid’s ability to translocate into the cell nucleus; however, the exact mechanism of this
Mikayla Hoad, Sepehr Nematollahzadeh, Gayle F. Petersen, Justin A. Roby, Gualtiero Alvisi, Jade K. Forwood   +5 more
doaj   +1 more source

Ezrin: a regulator of actin microfilaments in cell junctions of the rat testis

Asian Journal of Andrology, 2015
Ezrin, radixin, moesin and merlin (ERM) proteins are highly homologous actin-binding proteins that share extensive sequence similarity with each other.
N Ece Gungor-Ordueri, Ciler Celik-Ozenci, C Yan Cheng   +2 more
doaj   +1 more source

Risks Posed by Reston, the Forgotten Ebolavirus [PDF]

, 2016
Out of the five members of the Ebolavirus family, four cause lifethreatening disease, whereas the fifth, Reston virus (RESTV), is nonpathogenic in humans. The reasons for this discrepancy remain unclear. In this review, we analyze the currently available
Arran Hamlet, Carolyn B. Coyne, Diego Cantoni, Jeremy S. Rossman, Mark N. Wass, Martin Michaelis   +5 more
core   +2 more sources

Health Benefits and Therapeutic Potential of Quercetin

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Quercetin, a polyphenolic compound prevalent in many fruits, vegetables, and other dietary sources, has attracted considerable interest due to its extensive health benefits. This review examines its diverse biological properties, particularly its antioxidant and anti‐inflammatory effects. The study integrates recent scientific findings to elucidate the
Mahendra Aryal, Kim Wei Chan
wiley   +1 more source

Identifying a novel region in the Tembusu virus NS5 protein antagonizing type I interferon signaling

Journal of Virology
Numerous species in the genus Flavivirus have been identified to pose serious threats to public health. Most of them have developed evasion strategies to counteract antiviral activity triggered by type I interferon (IFN-I), making prevention and control ...
Ji Zhang, Yunhao Fan, Da An, Mingtian Mao, Zhanbao Guo, Jing Yang, Qiuyue Li, Siming Zhu, Guannan Li, Xin Chen, Zhengkui Zhou, Shuisheng Hou, Youxiang Diao, Yi Tang   +13 more
doaj   +1 more source

Putting things in place for fertilization: discovering roles for importin proteins in cell fate and spermatogenesis

Asian Journal of Andrology, 2015
Importin proteins were originally characterized for their central role in protein transport through the nuclear pores, the only intracellular entry to the nucleus.
Kate L. Loveland, Andrew T. Major, Romaly Butler, Julia C. Young, David A. Jans, Yoichi Miyamoto   +5 more
doaj   +1 more source

Components and regulation of nuclear transport processes [PDF]

, 2015
The spatial separation of DNA replication and gene transcription in the nucleus and protein translation in the cytoplasm is a uniform principle of eukaryotic cells. This compartmentalization imposes a requirement for a transport network of macromolecules
Alefantis, Argentaro, Arnaoutov, Arts, Arts, Askjaer, Bardina, Bayliss, Beals, Beck, Bednenko, Beg, Belov, Bernad, Bischoff, Bogerd, Bohnsack, Bohnsack, Bono, Bourne, Brickner, Bui, Bunn, Calado, Callan, Caly, Capelson, Carmody, Castello, Cautain, Chen, Chook, Ciufo, Conti, Conti, Cook, Cour, Craig, Cronshaw, Debler, Devos, Dingwall, Dong, Dong, Dorfman, Englmeier, Erickson, Erkmann, Ertel, Feng, Ferrigno, Field, Fineberg, Fischer, Fontoura, Fornerod, Fornerod, Frey, Frey, Fried, Frieman, Fu, Fu, Fukuda, Fukuda, Gadal, Ghildyal, Goldfarb, Gontan, Gorlich, Gorlich, Grespin, Grossman, Gustin, Gustin, Guttler, Hall, Harel, Hellmuth, Henderson, Hill, Hill, Ho, Hoelz, Holaska, Hopper, Huang, Huber, Hubner, Hung, Hussain, Hutten, Hutten, Isgro, Izaurralde, Kalab, Kalderon, Kalderon, Katahira, Kehlenbach, Kehlenbach, Kobbe, Kohler, Komeili, Kopecky-Bromberg, Kosugi, Kosugi, Kosugi, Krull, Kunzler, Kunzler, Kurisaki, Kutay, Kutay, Lam, Lange, Lange, Lange, Lee, Lee, Lidsky, Lim, Lim, Lim, Lim, Lindsay, Long, Luna, Lund, Macara, Maimon, Makkerh, Malik, Malim, Malim, Malim, Malim, Marfori, Mateo, Maurer, Melchior, Melcák, Mingot, Mingot, Mitchell, Monecke, Moore, Moore, Mor, Mosammaparast, Murdoch, Nemergut, Neumann, Ohno, Ossareh-Nazari, Paraskeva, Park, Peters, Porter, Prieto, Ren, Rexach, Ribbeck, Richards, Riviere, Rodriguez, Rodriguez-Navarro, Rouquette, Rout, Rout, Sarma, Schwartz, Shabman, Shin, Shuai, Siddiqui, Solsbacher, Sorokin, Speese, Stade, Stommel, Strambio-De-Castillia, Suel, Therizols, Thomas, Traenckner, Tran, Truant, Turner, Turner, Vosse, Wagstaff, Walther, Watters, Weighardt, Wen, Wen, Wente, Wild, Xu, Xu, Yang, Yi, Zanella   +203 more
core   +1 more source

Dualistic Roles of High Mobility Group Box 1 in Cancer and Inflammation

Cancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Background The High Mobility Group Box 1 (HMGB1) protein, a member of the HMG family, plays a crucial role in both cancer progression and inflammatory responses. HMGB1 can act as a damage‐associated molecular pattern (DAMP) to activate immune responses and modulate inflammation.
Wen Zeng, Xu Zhang, Yulu Jiang, Yuxiang Luo, Zuao Wang, Xiaohong Du, Leifeng Chen   +6 more
wiley   +1 more source