Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone [PDF]
eLife, 2019 We report the crystal structure of nuclear import receptor Importin-9 bound to its cargo, the histones H2A-H2B. Importin-9 wraps around the core, globular region of H2A-H2B to form an extensive interface.
Abhilash Padavannil +9 more
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Importin α1 contributes to Venezuelan equine encephalitis virus-induced cell death, but is not required for the capsid-mediated blockage of nucleocytoplasmic trafficking [PDF]
Frontiers in MicrobiologyAlphaviruses are single-stranded, enveloped, positive-sense RNA viruses within the family Togaviridae that cause significant human and veterinary disease worldwide.
Abdullahi T. Jamiu +13 more
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Karyopherin binding interactions and nuclear import mechanism of nuclear pore complex protein Tpr [PDF]
BMC Cell Biology, 2009 Background Tpr is a large protein with an extended coiled-coil domain that is localized within the nuclear basket of the nuclear pore complex. Previous studies 1 involving antibody microinjection into mammalian cells suggested a role for Tpr in nuclear ...
Frosst Phyllis D +2 more
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Ran modulates allosteric crosstalk between importin β surfaces [PDF]
Nature CommunicationsA cellular gradient of the GTPase Ran orchestrates the movement of import and export complexes through the Nuclear Pore Complex (NPC). Ran-GTP modulates two essential activities of importin β during nuclear import. On the one hand, it reduces the avidity
Ying-Hui Ko +6 more
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Ligands binding diffusively to protein target act as inhibitors of protein-protein interactions. [PDF]
PLoS Computational BiologyNuclear localization signal (NLS) sequence from capsid protein of Venezuelan equine encephalitis virus (VEEV) binds to importin-α transport protein and clogs nuclear import. Prevention of viral NLS binding to importin-α may represent a viable therapeutic
William Jeffries +12 more
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Structural characterization of human importin alpha 7 in its cargo-free form at 2.5 Å resolution
Scientific Reports, 2022 Shuttling of macromolecules between nucleus and cytoplasm is a tightly regulated process mediated through specific interactions between cargo and nuclear transport proteins.
S. Tsimbalyuk +2 more
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Drosophila Importin-α2 is involved in synapse, axon and muscle development. [PDF]
PLoS ONE, 2010 Nuclear import is required for communication between the cytoplasm and the nucleus and to enact lasting changes in gene transcription following stimuli.
Timothy J Mosca, Thomas L Schwarz
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Identification of Novel Stress Granule Components That Are Involved in Nuclear Transport. [PDF]
PLoS ONE, 2013 BACKGROUND:Importin-α1 belongs to a subfamily of nuclear transport adaptors and participates in diverse cellular functions. Best understood for its role in protein transport, importin-α1 also contributes to other biological processes.
Hicham Mahboubi +3 more
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Cell Reports, 2020 Summary: Importin-α adaptor proteins orchestrate dynamic nuclear transport processes involved in cellular homeostasis. Here, we show that importin-α3, one of the main NF-κB transporters, is the most abundantly expressed classical nuclear transport factor
Swantje Thiele +20 more
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A system-wide mislocalization of RNA-binding proteins in motor neurons is a new feature of ALS
Neurobiology of Disease, 2021 Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by progressive degeneration of motor neurons. Mislocalization of TAR DNA-binding protein 43 (TDP-43) is an early event in the formation of cytoplasmic TDP-43-positive inclusions ...
Yu-Ju Liu, Hung-Chih Kuo, Yijuang Chern
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