Results 1 to 10 of about 18,732 (155)

Importin α5 Regulates Anxiety through MeCP2 and Sphingosine Kinase 1

Cell Reports, 2018
Summary: Importins mediate transport from synapse to soma and from cytoplasm to nucleus, suggesting that perturbation of importin-dependent pathways should have significant neuronal consequences.
Mike Fainzilber, George Leondaritis, Didi-Andreas Song   +2 more
exaly   +4 more sources

Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP

Nature Communications, 2022
The translation of mechanical cues into gene expression changes is dependent on the nuclear import of mechanoresponsive transcriptional regulators. Here the authors identify that Importin-7 drives the nuclear import of one such regulator YAP while YAP ...
María García-García, Sara Sánchez-Perales, Patricia Jarabo, Enrique Calvo, Trevor Huyton, Liran Fu, Sheung Chun Ng, Laura Sotodosos-Alonso, Jesús Vázquez, Sergio Casas-Tintó, Dirk Görlich, Asier Echarri, Miguel A. Del Pozo   +12 more
doaj   +2 more sources

Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection

Cell Reports, 2020
Summary: Importin-α adaptor proteins orchestrate dynamic nuclear transport processes involved in cellular homeostasis. Here, we show that importin-α3, one of the main NF-κB transporters, is the most abundantly expressed classical nuclear transport factor
Swantje Thiele, Stephanie Stanelle-Bertram, Sebastian Beck, Nancy Mounogou Kouassi, Martin Zickler, Martin Müller, Berfin Tuku, Patricia Resa-Infante, Debby van Riel, Malik Alawi, Thomas Günther, Franziska Rother, Stefanie Hügel, Susanne Reimering, Alice McHardy, Adam Grundhoff, Wolfram Brune, Albert Osterhaus, Michael Bader, Enno Hartmann, Gülsah Gabriel   +20 more
doaj   +2 more sources

Ibetazol, a novel inhibitor of importin β1-mediated nuclear import

Communications Biology
Nucleocytoplasmatic transport plays an essential role in eukaryotic cell homeostasis and is mediated by karyopherins. Importin β1 (KPNB1) and its adaptor protein importin α1 (KPNA2) are the best-characterized karyopherins that effect nuclear import. Here,
Thomas Vercruysse, Els Vanstreels, Maarten Jacquemyn, Sandro Boland, Amuri Kilonda, Sara Allasia, Ilse Vandecaetsbeek, Hugo Klaassen, Matthias Versele, Patrick Chaltin, Arnaud Marchand, Dirk Daelemans   +11 more
doaj   +2 more sources

Importin α Partitioning to the Plasma Membrane Regulates Intracellular Scaling

Cell, 2019
Summary Early embryogenesis is accompanied by reductive cell divisions requiring that subcellular structures adapt to a range of cell sizes. The interphase nucleus and mitotic spindle scale with cell size through both physical and biochemical mechanisms,
Rebecca Heald, Christopher W Brownlee
exaly   +2 more sources

Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone

eLife, 2019
We report the crystal structure of nuclear import receptor Importin-9 bound to its cargo, the histones H2A-H2B. Importin-9 wraps around the core, globular region of H2A-H2B to form an extensive interface.
Abhilash Padavannil, Prithwijit Sarkar, Seung Joong Kim, Tolga Cagatay, Jenny Jiou, Chad A Brautigam, Diana R Tomchick, Andrej Sali, Sheena D'Arcy, Yuh Min Chook   +9 more
doaj   +2 more sources

Importin α1 contributes to Venezuelan equine encephalitis virus-induced cell death, but is not required for the capsid-mediated blockage of nucleocytoplasmic trafficking [PDF]

Frontiers in Microbiology
Alphaviruses are single-stranded, enveloped, positive-sense RNA viruses within the family Togaviridae that cause significant human and veterinary disease worldwide.
Abdullahi T. Jamiu, Abdullahi T. Jamiu, Ivan Akhrymuk, Grace Boyer, Gregory M. Petruncio, Maryna Akhrymuk, Bryan M. Delfing, Hui-Chen Foreman, Hui-Chen Foreman, Kenneth W. Foreman, Dmitri K. Klimov, Mikell Paige, Kylene Kehn-Hall, Kylene Kehn-Hall   +13 more
doaj   +2 more sources

Membrane association of importin α facilitates viral entry into salivary gland cells of vector insects

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance The importin α family is well known as a cargo transporter from the cytoplasm to the nucleus, with diverse functions in eukaryotes. However, some members of the importin α family also localize to the cell membrane.
Feng Cui, Wan Zhao
exaly   +2 more sources

Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1

Nature Communications, 2017
Importin α3 facilitates the nuclear transport of the Ran guanine nucleotide exchange factor RCC1. Here the authors reveal the molecular basis for the selectivity of RCC1 for importin α3 vs the generic importin α1 and discuss the evolution of importin α ...
Rajeshwer S. Sankhala, Ravi K. Lokareddy, Salma Begum, Ruth A. Pumroy, Richard E. Gillilan, Gino Cingolani   +5 more
doaj   +2 more sources

Importin α1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons.

PLoS Pathogens, 2018
Herpesviruses are large DNA viruses which depend on many nuclear functions, and therefore on host transport factors to ensure specific nuclear import of viral and host components. While some import cargoes bind directly to certain transport factors, most
Katinka Döhner, Ana Ramos-Nascimento, Dagmara Bialy, Fenja Anderson, Ana Hickford-Martinez, Franziska Rother, Thalea Koithan, Kathrin Rudolph, Anna Buch, Ute Prank, Anne Binz, Stefanie Hügel, Robert Jan Lebbink, Rob C Hoeben, Enno Hartmann, Michael Bader, Rudolf Bauerfeind, Beate Sodeik   +17 more
doaj   +2 more sources