Results 11 to 20 of about 21,607 (213)
Data on dimer formation between importin α subtypes [PDF]
Data in Brief, 2016 This article describes data related to the research article titled “Functional characterization of importin α8 as a classical nuclear localization signal receptor” [1].
Yoichi Miyamoto, Masahiro Oka
doaj +2 more sources
Importin α3 regulates chronic pain pathways in peripheral sensory neurons
Science, 2020 Nuclear transport controls chronic pain Chronic neuropathic pain is debilitating and difficult to treat. Marvaldi et al. now show that chronic pain is regulated by a specific nuclear import factor in peripheral sensory neurons (see the Perspective by ...
Letizia Marvaldi +15 more
semanticscholar +2 more sources
Differential recognition of canonical NF-κB dimers by Importin α3 [PDF]
Nature Communications, 2022 Nuclear translocation of the p50/p65 heterodimer is essential for NF-κB signaling. In unstimulated cells, p50/p65 is retained by the inhibitor IκBα in the cytoplasm that masks the p65-nuclear localization sequence (NLS).
Tyler J. Florio +6 more
semanticscholar +2 more sources
Karyopherin α7 (KPNA7), a divergent member of the importin α family of nuclear import receptors [PDF]
BMC Cell Biology, 2010 Background Classical nuclear localization signal (NLS) dependent nuclear import is carried out by a heterodimer of importin α and importin β. NLS cargo is recognized by importin α, which is bound by importin β.
Kelley Joshua B +4 more
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Scientific Reports, 2019 TMX2 is a thioredoxin family protein, but its functions have not been clarified. To elucidate the function of TMX2, we explored TMX2-interacting proteins by LC-MS. As a result, importin-β, Ran GTPase (Ran), RanGAP, and RanBP2 were identified.
Ami Oguro, Susumu Imaoka
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Ran modulates allosteric crosstalk between importin β surfaces [PDF]
Nature CommunicationsA cellular gradient of the GTPase Ran orchestrates the movement of import and export complexes through the Nuclear Pore Complex (NPC). Ran-GTP modulates two essential activities of importin β during nuclear import. On the one hand, it reduces the avidity
Ying-Hui Ko +6 more
doaj +2 more sources
Extensive Identification and In-depth Validation of Importin 13 Cargoes*
Molecular and Cellular Proteomics, 2018 Importin 13 is a member of the importin β family of transport receptors. Unlike most family members, importin 13 mediates both, nuclear protein import and export.
Kerstin Schmitt +2 more
exaly +2 more sources
Regulation of mitotic spindle assembly factor NuMA by Importin-β
Journal of Cell Biology, 2017 Ran–guanosine triphosphatase orchestrates mitotic spindle assembly by modulation of the interaction between Importin-&agr;/-&bgr; and spindle assembly factors (SAFs).
Chih-Chia Chang +4 more
semanticscholar +2 more sources
Importin 7 mediates the nuclear import of HIV-1 integrase via a specific interacting interface. [PDF]
FEBS Open BioHIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Bana J +5 more
europepmc +2 more sources
PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis-Associated Acute Lung Injury via AARS1-Mediated HIF-1α Lactylation. [PDF]
Adv Sci (Weinh)This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Li S +15 more
europepmc +2 more sources