BMC Cell Biology, 2008 Background Human importin beta has been used in all Xenopus laevis in vitro nuclear assembly and spindle assembly studies. This disconnect between species raised the question for us as to whether importin beta was an authentic negative regulator of cell ...
Forbes Douglass J +2 more
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The Drosophila importin-α3 is required for nuclear import of notch in vivo and it displays synergistic effects with notch receptor on cell proliferation. [PDF]
PLoS ONE, 2013 The Notch signaling pathway controls diverse cell-fate specification events throughout development. The versatility of this pathway to influence different aspects of development comes from its multiple levels of regulation.
Nalani Sachan +3 more
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Importin 7 and Importin α/Importin β Are Nuclear Import Receptors for the Glucocorticoid Receptor [PDF]
Molecular Biology of the Cell, 2004 The vertebrate glucocorticoid receptor (GR) is cytoplasmic without hormone and localizes to the nucleus after hormone binding. GR has two nuclear localization signals (NLS): NL1 is similar in sequence to the SV40 NLS; NL2 is poorly defined, residing in the ligand-binding domain.
Neal D, Freedman, Keith R, Yamamoto
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Importin α5 Regulates Anxiety through MeCP2 and Sphingosine Kinase 1
Cell Reports, 2018 Summary: Importins mediate transport from synapse to soma and from cytoplasm to nucleus, suggesting that perturbation of importin-dependent pathways should have significant neuronal consequences.
Nicolas Panayotis +15 more
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Diversification of importin-α isoforms in cellular trafficking and disease states. [PDF]
, 2015 The human genome encodes seven isoforms of importin α which are grouped into three subfamilies known as α1, α2 and α3. All isoforms share a fundamentally conserved architecture that consists of an N-terminal, autoinhibitory, importin-β-binding (IBB ...
Ahluwalia +221 more
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Functional divergence of microtubule-associated TPX2 family members in Arabidopsis thaliana [PDF]
, 2020 TPX2 (Targeting Protein for Xklp2) is an evolutionary conserved microtubule-associated protein important for microtubule nucleation and mitotic spindle assembly.
Demidov, Dmitri +9 more
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Data on dimer formation between importin α subtypes
Data in Brief, 2016 This article describes data related to the research article titled “Functional characterization of importin α8 as a classical nuclear localization signal receptor” [1].
Yoichi Miyamoto, Masahiro Oka
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Importin-beta and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function [PDF]
, 2017 Protein conjugation with small ubiquitin-related modifier (SUMO) is a post-translational modification that modulates protein interactions and localisation.
Damizia, Michela +7 more
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Importin α transports CaMKIV to the nucleus without utilizing importin β [PDF]
The EMBO Journal, 2005 Ca(2+)/calmodulin-dependent protein kinase type IV (CaMKIV) plays an essential role in the transcriptional activation of cAMP response element-binding protein-mediated signaling pathways. Although CaMKIV is localized predominantly in the nucleus, the molecular mechanism of the nuclear import of CaMKIV has not been elucidated.
Ippei, Kotera +7 more
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Indonesian Journal of Biotechnology, 2005 Isoform importin α molecules play a central role in the classical nuclear import pathway, that occurs through the nuclear pore complex (NPC) and typically requires a specific nuclear localization signal (NLS).
Aris Haryanto
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