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Ubiquitin-Proteasome System–Regulated Protein Degradation in Spermatogenesis
Spermatogenesis is a prolonged and highly ordered physiological process that produces haploid male germ cells through more than 40 steps and experiences dramatic morphological and cellular transformations.
Yi Xiong, Chao Yu, Qianting Zhang
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The Potential Role of Deubiquitinating Enzymes (DUBs) in Male Fertility [PDF]
Ubiquitination dynamically regulates critical cellular processes, including cell cycle progression, apoptosis, DNA repair, and chromatin remodeling. Deubiquitinating enzymes (DUBs) negatively regulate protein ubiquitination and are equally important for ...
Jung Min Kim
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Advances in research on RNA N-6-methyladenosine(m6A) modification related enzymes in mammalian spermatogenesis [PDF]
N-6-methyladenosine(m6A) has been well-known to be a type of RNA epigenetic modification over the past decade. The m6A modification enzymes include “Writers” (METTL3/14/WTAP, etc.),“Erasers” (FTO and ALKBH5) and “Readers” (YTHDC1/2,YTHDF1/2/3, etc ...
ZHANG Qiang, SU Wenhui
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Spermatogenesis is a complex process occurring in mammalian testes, and constant sperm production depends on the exact regulation of the microenvironment in the testes.
Yu Zhou, Yunyan Wang
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Functions of somatic cells for spermatogenesis in stallions
Spermatogenesis and testis development are highly structured physiological processes responsible for post-pubertal fertility in stallions. Spermatogenesis comprises spermatocytogenesis, meiosis, and spermiogenesis.
Muhammad Shakeel, Minjung Yoon
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Transcriptome profiling of developing testes and spermatogenesis in the Mongolian horse
Background Horse testis development and spermatogenesis are complex physiological processes. Methods To study these processes, three immature and three mature testes were collected from the Mongolian horse, and six libraries were established using high ...
Bei Li +8 more
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Three-Dimensional Analysis of Busulfan-Induced Spermatogenesis Disorder in Mice
We examined if the distribution of impaired or normal spermatogenesis differs along the length of seminiferous tubules in disorders of spermatogenesis. For this purpose, three-dimensional (3D) reconstruction of seminiferous tubules was performed in mice ...
Hiroki Nakata +3 more
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In vitro mouse spermatogenesis with an organ culture method in chemically defined medium. [PDF]
We previously reported the successful induction and completion of mouse spermatogenesis by culturing neonatal testis tissues. The culture medium consisted of α-minimum essential medium (α-MEM), supplemented with Knockout serum replacement (KSR) or ...
Hiroyuki Sanjo +13 more
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Spermatogenesis is a complex and continuous process of germ-cell differentiation. This complex process is regulated by many factors, of which gene regulation in spermatogenic cells plays a decisive role.
Yanan Li +11 more
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Testicular endothelial cells have been found to play an important role in spermatogenesis and fertility, but their mechanism is obscure. Exosomes released by various cells are recognized as cell–cell communication mediators during the initiation and ...
Wen-Peng Song +7 more
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