Results 1 to 10 of about 57,423 (263)

Ubiquitin-Proteasome System–Regulated Protein Degradation in Spermatogenesis

open access: yesCells, 2022
Spermatogenesis is a prolonged and highly ordered physiological process that produces haploid male germ cells through more than 40 steps and experiences dramatic morphological and cellular transformations.
Yi Xiong, Chao Yu, Qianting Zhang
doaj   +3 more sources

The Potential Role of Deubiquitinating Enzymes (DUBs) in Male Fertility [PDF]

open access: yesBiomolecules
Ubiquitination dynamically regulates critical cellular processes, including cell cycle progression, apoptosis, DNA repair, and chromatin remodeling. Deubiquitinating enzymes (DUBs) negatively regulate protein ubiquitination and are equally important for ...
Jung Min Kim
doaj   +2 more sources

Advances in research on RNA N-6-methyladenosine(m6A) modification related enzymes in mammalian spermatogenesis [PDF]

open access: yesJichu yixue yu linchuang, 2023
N-6-methyladenosine(m6A) has been well-known to be a type of RNA epigenetic modification over the past decade. The m6A modification enzymes include “Writers” (METTL3/14/WTAP, etc.),“Erasers” (FTO and ALKBH5) and “Readers” (YTHDC1/2,YTHDF1/2/3, etc ...
ZHANG Qiang, SU Wenhui
doaj   +1 more source

Action and Interaction between Retinoic Acid Signaling and Blood–Testis Barrier Function in the Spermatogenesis Cycle

open access: yesCells, 2022
Spermatogenesis is a complex process occurring in mammalian testes, and constant sperm production depends on the exact regulation of the microenvironment in the testes.
Yu Zhou, Yunyan Wang
doaj   +1 more source

Functions of somatic cells for spermatogenesis in stallions

open access: yesJournal of Animal Science and Technology, 2022
Spermatogenesis and testis development are highly structured physiological processes responsible for post-pubertal fertility in stallions. Spermatogenesis comprises spermatocytogenesis, meiosis, and spermiogenesis.
Muhammad Shakeel, Minjung Yoon
doaj   +1 more source

Transcriptome profiling of developing testes and spermatogenesis in the Mongolian horse

open access: yesBMC Genetics, 2020
Background Horse testis development and spermatogenesis are complex physiological processes. Methods To study these processes, three immature and three mature testes were collected from the Mongolian horse, and six libraries were established using high ...
Bei Li   +8 more
doaj   +1 more source

Three-Dimensional Analysis of Busulfan-Induced Spermatogenesis Disorder in Mice

open access: yesFrontiers in Cell and Developmental Biology, 2020
We examined if the distribution of impaired or normal spermatogenesis differs along the length of seminiferous tubules in disorders of spermatogenesis. For this purpose, three-dimensional (3D) reconstruction of seminiferous tubules was performed in mice ...
Hiroki Nakata   +3 more
doaj   +1 more source

In vitro mouse spermatogenesis with an organ culture method in chemically defined medium. [PDF]

open access: yesPLoS ONE, 2018
We previously reported the successful induction and completion of mouse spermatogenesis by culturing neonatal testis tissues. The culture medium consisted of α-minimum essential medium (α-MEM), supplemented with Knockout serum replacement (KSR) or ...
Hiroyuki Sanjo   +13 more
doaj   +1 more source

Single-Cell RNA Sequencing of the Testis of Ciona intestinalis Reveals the Dynamic Transcriptional Profile of Spermatogenesis in Protochordates

open access: yesCells, 2022
Spermatogenesis is a complex and continuous process of germ-cell differentiation. This complex process is regulated by many factors, of which gene regulation in spermatogenic cells plays a decisive role.
Yanan Li   +11 more
doaj   +1 more source

Proteomic analysis and miRNA profiling of human testicular endothelial cell-derived exosomes: the potential effects on spermatogenesis

open access: yesAsian Journal of Andrology, 2022
Testicular endothelial cells have been found to play an important role in spermatogenesis and fertility, but their mechanism is obscure. Exosomes released by various cells are recognized as cell–cell communication mediators during the initiation and ...
Wen-Peng Song   +7 more
doaj   +1 more source

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