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Androgens and spermatogenesis

open access: yesAnnales d'Endocrinologie, 2022
Male infertility contributes to 50% of all cases of infertility. The main cause is low quality and quantity of sperm. In humans, spermatogenesis starts at the beginning of puberty and lasts lifelong. It is under the control of FSH and testicular androgens, and mainly testosterone (T), and therefore requires a normal gonadotroph axis, intratesticular T ...
Sophie, Christin-Maitre, Jacques, Young
openaire   +3 more sources

Spermatogenesis, Mammals

open access: yes, 2013
Spermatogenesis occurs in the seminiferous tubule of the testis to produce millions of spermatozoa per day, with each spermatozoon containing a haploid complement of chromosomes.
C.Y. Cheng, D.D. Mruk
openaire   +2 more sources

Spermatogenesis [PDF]

open access: yesCurrent Biology, 2017
Most organisms consist of two cell lineages - somatic cells and germ cells. The former are required for the current generation, and the latter create offspring. Male and female germ cells are usually produced during spermatogenesis and oogenesis, which take place in the testis and the ovary, respectively. Spermatogenesis involves the differentiation of
Hitoshi, Nishimura, Steven W, L'Hernault
  +7 more sources

Spermatogenesis [PDF]

open access: yesHuman Reproduction, 1998
Spermatogenesis is a complex process involving mitotic cell division, meiosis and the process of spermiogenesis. The regulation of spermatogenesis involves both endocrine and paracrine mechanisms. The endocrine stimulation of spermatogenesis involves both follicle stimulating hormone (FSH) and luteinizing hormone, the latter acting through the ...
D M, de Kretser   +4 more
openaire   +2 more sources

Spermatogenesis and Cryptorchidism [PDF]

open access: yesFrontiers in Endocrinology, 2014
Cryptorchidism represents the most common endocrine disease in boys, with infertility more frequently observed in bilateral forms. It is also known that undescended testes, if untreated, lead to an increased risk of testicular tumors, usually seminomas, arising from mutant germ cells.
Cobellis G   +7 more
openaire   +3 more sources

Kinesins in spermatogenesis† [PDF]

open access: yesBiology of Reproduction, 2017
Kinesins are essential for the proper function of many types of polar cells, including epithelial cells, neurons, and sperm. Spermatogenesis is closely associated with many different kinesins. These kinesins participate in several fundamental processes, including mitotic and meiotic division, essential organelle transport, and the biogenesis of ...
Dan-Dan, Ma, Da-Hui, Wang, Wan-Xi, Yang
openaire   +2 more sources

The cytoskeleton in spermatogenesis [PDF]

open access: yesReproduction, 2019
Abstract As germ cells progress through spermatogenesis, they undergo a dramatic transformation, wherein a single, diploid spermatogonial stem cell ultimately produces thousands of highly specialised, haploid spermatozoa. The cytoskeleton is an integral aspect of all eukaryotic cells.
Dunleavy, J.E.M.   +3 more
openaire   +3 more sources

Spermatogenesis [PDF]

open access: yesWormBook, 2006
Spermatogenesis creates functional sperm from an initially undifferentiated germ cell. In the nematode Caenorhabditis elegans, both males and hermaphrodites engage in spermatogenesis. The hermaphrodite germ line, like that of the male, initiates spermatogenesis during the L4 larval stage.
openaire   +3 more sources

Spermatogenesis in the Microminipig [PDF]

open access: yesToxicologic Pathology, 2016
The microminipig has considerable potential as an animal model to evaluate general toxicity; however, there are few studies on the male reproductive system, particularly regarding spermatogenesis. The objectives of the present study were to clarify the stages of the seminiferous epithelium cycle on the basis of spermiogenesis and to determine the ...
Akihisa, Kangawa   +5 more
openaire   +2 more sources

Direct action through the Sertoli cells is essential for androgen stimulation of spermatogenesis [PDF]

open access: yes, 2010
Androgens act to stimulate spermatogenesis through androgen receptors (AR) on the Sertoli cells and peritubular myoid cells (PTM). Specific ablation of the AR in either cell type will cause a severe disruption of spermatogenesis.
Abel, M.H.   +4 more
core   +1 more source

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