Results 11 to 20 of about 121,335 (279)

In vitro mouse spermatogenesis with an organ culture method in chemically defined medium. [PDF]

PLoS ONE, 2018
We previously reported the successful induction and completion of mouse spermatogenesis by culturing neonatal testis tissues. The culture medium consisted of α-minimum essential medium (α-MEM), supplemented with Knockout serum replacement (KSR) or ...
Hiroyuki Sanjo, Mitsuru Komeya, Takuya Sato, Takeru Abe, Kumiko Katagiri, Hiroyuki Yamanaka, Yoko Ino, Noriaki Arakawa, Hisashi Hirano, Tatsuma Yao, Yuta Asayama, Akio Matsuhisa, Masahiro Yao, Takehiko Ogawa   +13 more
doaj   +1 more source

Loss of Cx43 in Murine Sertoli Cells Leads to Altered Prepubertal Sertoli Cell Maturation and Impairment of the Mitosis-Meiosis Switch. [PDF]

, 2020
Male factor infertility is a problem in today's society but many underlying causes are still unknown. The generation of a conditional Sertoli cell (SC)-specific connexin 43 (Cx43) knockout mouse line (SCCx43KO) has provided a translational model ...
Behr, Rüdiger, Brehm, Ralph HJ, Distl, Ottmar, Hilbold, Erika, Hoedemaker, Martina, Jung, Klaus, Langeheine, Marion, Metzger, Julia, Rajkovic, Aleksandar, Rode, Kristina, Wilkening, Sandra   +10 more
core   +1 more source

Single-Cell RNA Sequencing of the Testis of Ciona intestinalis Reveals the Dynamic Transcriptional Profile of Spermatogenesis in Protochordates

Cells, 2022
Spermatogenesis is a complex and continuous process of germ-cell differentiation. This complex process is regulated by many factors, of which gene regulation in spermatogenic cells plays a decisive role.
Yanan Li, Xiang Liu, Xianghui Zhang, Hongyan Wang, Jianyang Chen, Jiankai Wei, Yubang Li, Hongxi Chen, Qian Wang, Kaiqiang Liu, Yuyan Liu, Changwei Shao   +11 more
doaj   +1 more source

Spermatogenesis and Cryptorchidism [PDF]

Frontiers in Endocrinology, 2014
Cryptorchidism represents the most common endocrine disease in boys, with infertility more frequently observed in bilateral forms. It is also known that undescended testes, if untreated, lead to an increased risk of testicular tumors, usually seminomas, arising from mutant germ cells.
Cobellis G, Noviello C, Nino F, Romano M, Mariscoli F, Martino A, PARMEGGIANI, Pio, PAPPARELLA, Alfonso   +7 more
openaire   +3 more sources

Ubiquitin-Proteasome System–Regulated Protein Degradation in Spermatogenesis

Cells, 2022
Spermatogenesis is a prolonged and highly ordered physiological process that produces haploid male germ cells through more than 40 steps and experiences dramatic morphological and cellular transformations.
Yi Xiong, Chao Yu, Qianting Zhang
doaj   +1 more source

Proteomic analysis and miRNA profiling of human testicular endothelial cell-derived exosomes: the potential effects on spermatogenesis

Asian Journal of Andrology, 2022
Testicular endothelial cells have been found to play an important role in spermatogenesis and fertility, but their mechanism is obscure. Exosomes released by various cells are recognized as cell–cell communication mediators during the initiation and ...
Wen-Peng Song, Sheng-Ji Gu, Xiao-Hui Tan, Yang-Yang Gu, Wei-Dong Song, Jian-Yu Zeng, Zhong-Cheng Xin, Rui-Li Guan   +7 more
doaj   +1 more source

Methylation of the Gpat2 promoter regulates transient expression during mouse spermatogenesis [PDF]

, 2015
Spermatogenesis is a highly regulated process that involves both mitotic and meiotic divisions, as well as cellular differentiation to yield mature spermatozoa from undifferentiated germinal stem cells.
Cattaneo, Elizabeth Renee, Coleman, Rosalind A., Garcia Fabiani, Maria Belen, Gonzalez-Baró, Lacunza, Ezequiel, Montanaro, Mauro Aldo, Pellon Maison, Magali   +6 more
core   +2 more sources

Transcriptome profiling of laser-captured germ cells and functional characterization of zbtb40 during 17alpha-methyltestosterone-induced spermatogenesis in orange-spotted grouper (Epinephelus coioides)

BMC Genomics, 2020
Background Spermatogenesis is an intricate process regulated by a finely organized network. The orange-spotted grouper (Epinephelus coioides) is a protogynous hermaphroditic fish, but the regulatory mechanism of its spermatogenesis is not well-understood.
Xi Wu, Yang Yang, Chaoyue Zhong, Yin Guo, Shuisheng Li, Haoran Lin, Xiaochun Liu   +6 more
doaj   +1 more source

Developmental changes in the histological structure of the testes, and testosterone profiles in male guinea fowls (Numida meleagris) [PDF]

, 2017
Owing to the paucity of information on the reproductive biology of guinea fowls, a study involving a total of 66 males was conducted, and documented the developmental changes in histological structure of the testes of guinea cocks from hatching until ...
Abdul-Rahman, Iddriss I., Jeffcoate, Ian A., Obese, Frederick Y.   +2 more
core   +1 more source

Testicular expression of TDRD1, TDRD5, TDRD9 and TDRD12 in azoospermia. [PDF]

, 2020
BACKGROUND: Tudor domain-containing proteins (TDRDs) play a critical role in piRNA biogenesis and germ cell development. piRNAs, small regulatory RNAs, act by silencing of transposons during germline development and it has recently been shown in animal ...
Aghaei, M, Alipourfard, I, Babakhanzadeh, E, Ghasemi, N, Hosseinnia, M, Jamshidi, Y, Khodadadian, A, Mehrjardi, MYV, Nazari, M, Rostami, S   +9 more
core   +1 more source