Data in Brief, 2023 53BP1 (TP53-binding protein 1), a key player in DNA double-strand break repair, has a classical bipartite nuclear localization signal (NLS) of sequence 1666-GKRKLITSEEERSPAKRGRKS-1686 that binds to importin-α, a nuclear import adaptor protein ...
Yoshiyuki Matsuura
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Mitotic spindle scaling during Xenopus development by kif2a and importin α. [PDF]
, 2012 Early development of many animals is characterized by rapid cleavages that dramatically decrease cell size, but how the mitotic spindle adapts to changing cell dimensions is not understood.
HEALD, Rebecca, Wilbur, Jeremy
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Karyopherin α7 (KPNA7), a divergent member of the importin α family of nuclear import receptors
BMC Cell Biology, 2010 Background Classical nuclear localization signal (NLS) dependent nuclear import is carried out by a heterodimer of importin α and importin β. NLS cargo is recognized by importin α, which is bound by importin β.
Kelley Joshua B +4 more
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UV-induced nuclear import of XPA is mediated by importin-α4 in an ATR-dependent manner. [PDF]
PLoS ONE, 2013 Xeroderma pigmentosum Group A (XPA) is a crucial factor in mammalian nucleotide excision repair (NER) and nuclear import of XPA from the cytoplasm for NER is regulated in cellular DNA damage responses in S-phase.
Zhengke Li +4 more
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The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence [PDF]
, 2016 AKTIP is a shelterin-interacting protein required for replication of telomeric DNA. Here, we show that AKTIP biochemically interacts with A- and B-type lamins and affects lamin A, but not lamin C or B, expression.
Astrologo, Letizia +14 more
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Structural characterisation of TNRC6A nuclear localisation signal in complex with importin-alpha. [PDF]
PLoS ONE, 2017 The GW182/TNRC6 family of proteins are central scaffolds that link microRNA-associated Argonaute proteins to the cytoplasmic decay machinery for targeted mRNA degradation processes.
Jessica J Chaston +2 more
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Comparative proteomic profiling reveals molecular characteristics associated with oogenesis and oocyte maturation during ovarian development of Bactrocera dorsalis (Hendel) [PDF]
, 2017 Time-dependent expression of proteins in ovary is important to understand oogenesis in insects. Here, we profiled the proteomes of developing ovaries from Bactrocera dorsalis (Hendel) to obtain information about ovarian development with particular ...
Wei, Dong +6 more
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Higher nucleoporin-Importinβ affinity at the nuclear basket increases nucleocytoplasmic import. [PDF]
, 2013 Several in vitro studies have shown the presence of an affinity gradient in nuclear pore complex proteins for the import receptor Importinβ, at least partially contributing to nucleocytoplasmic transport, while others have historically argued against the
Azimi, Mohammad, Mofrad, Mohammad
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Dynamics of the STAT3 transcription factor: nuclear import dependent on Ran and importin-β1. [PDF]
PLoS ONE, 2011 The signal transducer and activator of transcription-3 (STAT3) induces transcription of genes that control differentiation, inflammation, proliferation, and tumor cell invasion.
Velasco Cimica +3 more
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The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability [PDF]
, 2009 Myc-induced SUN domain–containing protein (Misu or NSun2) is a nucleolar RNA methyltransferase important for c-Myc–induced proliferation in skin, but the mechanisms by which Misu contributes to cell cycle progression are unknown.
Shobbir Hussain +49 more
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