Results 21 to 30 of about 21,607 (213)
Cell Reports, 2023 A hexanucleotide (GGGGCC)n repeat expansion in C9orf72 causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), eliciting toxic effects through generation of RNA foci, dipeptide repeat proteins, and/or loss of C9orf72 protein ...
P. McGoldrick +4 more
semanticscholar +1 more source
Viral Targeting of Importin Alpha-Mediated Nuclear Import to Block Innate Immunity
Cells, 2023 Cellular nucleocytoplasmic trafficking is mediated by the importin family of nuclear transport proteins. The well-characterized importin alpha (IMPA) and importin beta (IMPB) nuclear import pathway plays a crucial role in the innate immune response to ...
Olivia A. Vogel +4 more
semanticscholar +1 more source
Recognition of the TDP-43 nuclear localization signal by importin α1/β
Cell Reports, 2022 SUMMARY Cytoplasmic mislocalization of the TAR-DNA binding protein of 43 kDa (TDP-43) leads to large, insoluble aggregates that are a hallmark of amyotrophic lateral sclerosis and frontotemporal dementia.
Steven G. Doll +9 more
semanticscholar +1 more source
Structural characterization of human importin alpha 7 in its cargo-free form at 2.5 Å resolution
Scientific Reports, 2022 Shuttling of macromolecules between nucleus and cytoplasm is a tightly regulated process mediated through specific interactions between cargo and nuclear transport proteins.
S. Tsimbalyuk +2 more
doaj +1 more source
Cellular & Molecular Immunology, 2022 As a major component of the viral ribonucleoprotein (vRNP) complex in influenza A virus (IAV), nucleoprotein (NP) interacts with isoforms of importin α family members, leading to the import of itself and vRNP complex into the nucleus, a process pivotal ...
Xuyuan Wang +12 more
semanticscholar +1 more source
Importin α: a key molecule in nuclear transport and non-transport functions.
Journal of Biochemistry, 2016 Yoichi Miyamoto, Kohji Yamada
exaly +2 more sources
Structure of IMPORTIN-4 bound to the H3–H4–ASF1 histone–histone chaperone complex
bioRxiv, 2022 Importin-4 is the primary nuclear import receptor of core histones H3 and H4. Importin-4 binds the H3-H4 dimer and histone-chaperone ASF1 prior to nuclear import, but available structures of Importin-4·histone tail complexes do not explain how Importin-4
N. E. Bernardes +4 more
semanticscholar +1 more source
Human Enzyme PADI4 Binds to the Nuclear Carrier Importin α3
Cells, 2022 PADI4 is a peptidyl-arginine deiminase (PADI) involved in the conversion of arginine to citrulline. PADI4 is present in macrophages, monocytes, granulocytes, and several cancer cells. It is the only PADI family member observed within both the nucleus and
J. Neira +5 more
semanticscholar +1 more source
A system-wide mislocalization of RNA-binding proteins in motor neurons is a new feature of ALS
Neurobiology of Disease, 2021 Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by progressive degeneration of motor neurons. Mislocalization of TAR DNA-binding protein 43 (TDP-43) is an early event in the formation of cytoplasmic TDP-43-positive inclusions ...
Yu-Ju Liu, Hung-Chih Kuo, Yijuang Chern
doaj +1 more source
Drosophila Importin-α2 is involved in synapse, axon and muscle development. [PDF]
PLoS ONE, 2010 Nuclear import is required for communication between the cytoplasm and the nucleus and to enact lasting changes in gene transcription following stimuli.
Timothy J Mosca, Thomas L Schwarz
doaj +1 more source