Identification of a novel nuclear localization signal in Sam68 [PDF]
FEBS Letters, 1997 Sam68, a nuclear RNA binding protein, binds to Src and is phosphorylated at tyrosine residues in an M-phase specific manner. Here we identified a stretch of 24 amino acid residues in the COOH-terminal portion of Sam68 which function as a nuclear ...
Satoshi Yoshihara +2 more
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Crystallographic data of an importin-α3 dimer in which the two protomers are bridged by a bipartite nuclear localization signal [PDF]
Data in Brief, 2023 53BP1 (TP53-binding protein 1), a key player in DNA double-strand break repair, has a classical bipartite nuclear localization signal (NLS) of sequence 1666-GKRKLITSEEERSPAKRGRKS-1686 that binds to importin-α, a nuclear import adaptor protein ...
Yoshiyuki Matsuura
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Henipavirus Matrix Protein Employs a Non-Classical Nuclear Localization Signal Binding Mechanism [PDF]
Viruses, 2023 Nipah virus (NiV) and Hendra virus (HeV) are highly pathogenic species from the Henipavirus genus within the paramyxovirus family and are harbored by Pteropus Flying Fox species.
Camilla M. Donnelly +6 more
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The nuclear localization signal of CPSF6 governs post-nuclear import steps of HIV-1 infection. [PDF]
PLoS PathogensThe early stages of HIV-1 infection include the trafficking of the viral core into the nucleus of infected cells. However, much remains to be understood about how HIV-1 accomplishes nuclear import and the consequences of the import pathways utilized on ...
Nicholas Rohlfes +6 more
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Identification and functional characterization of a bipartite nuclear localization signal in ANKRD11
Biochemical and Biophysical Research Communications, 2023 ANKRD11 gene encodes for the large nuclear protein essential for multiple system development including the nervous system. However, the molecular basis for the proper nuclear localization of ANKRD11 has not yet been elucidated.
Haiyang Liu, Jun Wan
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Identification of a nuclear localization signal in the polo box domain of Plk1
Biochimica Et Biophysica Acta - Molecular Cell Research, 2009 Polo-like kinase 1 plays an essential role in mitosis and cytokinesis. Expression and nuclear localization of Plk1 during the S phase are necessary for its functions.
Moon-Sing Lee
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Molecular and Cellular Endocrinology, 2017 The localization of glucokinase in pancreatic beta-cell nuclei is a controversial issue. Although previous reports suggest such a localization, the mechanism for its import has so far not been identified.
Bente B Johansson +2 more
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Recognition of the TDP-43 nuclear localization signal by importin α1/β [PDF]
Cell Reports, 2022 Steven G Doll +2 more
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Dissection of a Nuclear Localization Signal [PDF]
Journal of Biological Chemistry, 2001 The regulated process of protein import into the nucleus of a eukaryotic cell is mediated by specific nuclear localization signals (NLSs) that are recognized by protein import receptors. This study seeks to decipher the energetic details of NLS recognition by the receptor importin alpha through quantitative analysis of variant NLSs.
M R, Hodel, A H, Corbett, A E, Hodel
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Finding nuclear localization signals [PDF]
EMBO reports, 2000 A variety of nuclear localization signals (NLSs) are experimentally known although only one motif was available for database searches through PROSITE. We initially collected a set of 91 experimentally verified NLSs from the literature.
M, Cokol, R, Nair, B, Rost
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