Crystallographic data of an importin-α3 dimer in which the two protomers are bridged by a bipartite nuclear localization signal [PDF]
Data in Brief, 2023 53BP1 (TP53-binding protein 1), a key player in DNA double-strand break repair, has a classical bipartite nuclear localization signal (NLS) of sequence 1666-GKRKLITSEEERSPAKRGRKS-1686 that binds to importin-α, a nuclear import adaptor protein ...
Yoshiyuki Matsuura
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Henipavirus Matrix Protein Employs a Non-Classical Nuclear Localization Signal Binding Mechanism [PDF]
Viruses, 2023 Nipah virus (NiV) and Hendra virus (HeV) are highly pathogenic species from the Henipavirus genus within the paramyxovirus family and are harbored by Pteropus Flying Fox species.
Camilla M. Donnelly +6 more
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The nuclear localization signal of CPSF6 governs post-nuclear import steps of HIV-1 infection. [PDF]
PLoS PathogensThe early stages of HIV-1 infection include the trafficking of the viral core into the nucleus of infected cells. However, much remains to be understood about how HIV-1 accomplishes nuclear import and the consequences of the import pathways utilized on ...
Nicholas Rohlfes +6 more
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Recognition of the TDP-43 nuclear localization signal by importin α1/β [PDF]
Cell Reports, 2022 Hamed Meshkin +2 more
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Poultry Science, 2021 Duck enteritis virus (DEV) multifunctional tegument protein UL13 is predicted to be a conserved herpesvirus protein kinase; however, little is known about its subcellular localization signal.
Linjiang Yang +23 more
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Types of nuclear localization signals and mechanisms of protein import into the nucleus
Cell Communication and Signaling, 2021 Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment that mediates the transport of proteins from the cytoplasm into the nucleus.
Juane Lu +6 more
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Biology Direct, 2020 Background The origin of the selective nuclear protein import machinery, which consists of nuclear pore complexes and adaptor molecules interacting with the nuclear localization signals (NLSs) of cargo molecules, is one of the most important events in ...
Olga M. Lisitsyna +6 more
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Functional dissection of N-terminal nuclear trafficking signals of SETDB1
Frontiers in Cell and Developmental Biology, 2022 SETDB1 is a histone H3-lysine 9-specific methyltransferase that fulfills epigenetic functions inside the nucleus; however, when overexpressed, SETDB1 majorily localizes in the cytoplasm. SETDB1 has a single nuclear-localization-signal (NLS) motif and two
Jaemin Eom +6 more
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Nuclear export of L-periaxin, mediated by its nuclear export signal in the PDZ domain. [PDF]
PLoS ONE, 2014 Myelinating Schwann cells specifically express L-periaxin (L-PRX) in the mammalian peripheral nervous system. Several loss-of-function mutations in periaxin have been described and linked to autosomal recessive Dejerine Sottas neuropathy and to ...
Yawei Shi, Lei Zhang, Ting Yang
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Mechanisms of GnRH-induced extracellular signal-regulated kinase nuclear localization. [PDF]
PLoS ONE, 2012 Gonadotropin-releasing hormone receptors (GnRHR) mediate activation and nuclear translocation of the extracellular signal regulated kinases 1 and 2 (ERK) by phosphorylation on the TEY motif.
Christopher J Caunt +3 more
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