PLoS ONE, 2015 The Ran GTPase activating protein RanGAP1 plays an essential role in nuclear transport by stimulating RanGTP hydrolysis in the cytoplasmic compartment.
Keith Cha +3 more
doaj +1 more source
Identification of a classical bipartite nuclear localization signal in the Drosophila TEA/ATTS protein scalloped. [PDF]
PLoS ONE, 2011 Drosophila melanogaster wing development has been shown to rely on the activity of a complex of two proteins, Scalloped (Sd) and Vestigial (Vg). Within this complex, Sd is known to provide DNA binding though its TEA/ATTS domain, while Vg modulates this ...
Adam C Magico, John B Bell
doaj +1 more source
The A78V mutation in the Mad3-like domain of Schizosaccharomyces pombe Bub1p perturbs nuclear accumulation and kinetochore targeting of Bub1p, Bub3p, and Mad3p and spindle assembly checkpoint function [PDF]
, 2005 During mitosis, the spindle assembly checkpoint (SAC) responds to faulty attachments between kinetochores and the mitotic spindle by imposing a metaphase arrest until the defect is corrected, thereby preventing chromosome missegregation. A genetic screen
Vanoosthuyse, V. +6 more
core +1 more source
Identification of a functional nuclear localization signal mediating nuclear import of the zinc finger transcription factor ZNF24. [PDF]
PLoS ONE, 2013 ZNF24 is a member of the SCAN domain family of Krüppel-like zinc finger (ZF) transcription factors, which plays a critical role in cell proliferation and differentiation.
Jian-Zhong Li +9 more
doaj +1 more source
Subdomain-specific localization of CLIMP-63 (p63) in the endoplasmic reticulum is mediated by its luminal alpha-helical segment [PDF]
, 2001 The microtubule-binding integral 63 kD cytoskeleton-linking membrane protein (CLIMP-63; former name, p63) of the rough endoplasmic reticulum (ER) is excluded from the nuclear envelope.
Klopfenstein, D. R. +17 more
core +1 more source
Nuclear localization is required for Dishevelled function in Wnt/β-catenin signaling
Journal of Biology, 2005 Background Dishevelled (Dsh) is a key component of multiple signaling pathways that are initiated by Wnt secreted ligands and Frizzled receptors during embryonic development.
Sokol Sergei Y +4 more
doaj +1 more source
Analysis of Domains Affecting Intracellular Localization of the FMRP Protein
Neurobiology of Disease, 1997 Fragile X syndrome is the most frequent form of inherited mental retardation and it is caused by deficiency of FMRP, the protein encoded by the FMR1 gene. FMRP is a RNA binding protein of unknown function which is associated with ribosomes. FMRP is found
B. Bardoni +3 more
doaj +1 more source
Nuclear Targeting Dynamics of Gold Nanoclusters for Enhanced Therapy of HER2(+) Breast Cancer [PDF]
, 2011 Recent advances in fluorescent metal nanoclusters have spurred tremendous interest In nanomedicine due to the ease of fabrication, excellent biocompatibility, and, more Importantly, excellent wavelength-dependent tunability.
Joseph Irudayaraj +5 more
core +2 more sources
Simplet/Fam53b is required for Wnt signal transduction by regulating beta-catenin nuclear localization [PDF]
, 2014 Canonical beta-catenin-dependent Wnt signal transduction is important for several biological phenomena, such as cell fate determination, cell proliferation, stem cell maintenance and anterior-posterior axis formation.
Kuechler, Beate +8 more
core +3 more sources
Mediated nuclear import and export of TAZ and the underlying molecular requirements
Nature Communications, 2018 The transcriptional co-factors Yap and TAZ are regulated by Hippo signalling and mechanical forces via their nucleocytoplasmic shuttling. Here the authors identify a RhoA-regulated C-terminal nuclear localization signal and a TEAD-regulated N-terminal ...
Michael Kofler +5 more
doaj +1 more source