The role of nuclear localization signal in parvovirus life cycle
Virology Journal, 2017 Parvoviruses are small, non-enveloped viruses with an approximately 5.0 kb, single-stranded DNA genome. Usually, the parvovirus capsid gene contains one or more nuclear localization signals (NLSs), which are required for guiding the virus particle into ...
Peng Liu +3 more
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NLSdb—major update for database of nuclear localization signals and nuclear export signals [PDF]
Nucleic Acids Research, 2017 NLSdb is a database collecting nuclear export signals (NES) and nuclear localization signals (NLS) along with experimentally annotated nuclear and non-nuclear proteins. NES and NLS are short sequence motifs related to protein transport out of and into the nucleus. The updated NLSdb now contains 2253 NLS and introduces 398 NES.
Michael Bernhofer +6 more
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Data on dimer formation between importin α subtypes
Data in Brief, 2016 This article describes data related to the research article titled “Functional characterization of importin α8 as a classical nuclear localization signal receptor” [1].
Yoichi Miyamoto, Masahiro Oka
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The Effector Domain of MARCKS Is a Nuclear Localization Signal that Regulates Cellular PIP2 Levels and Nuclear PIP2 Localization. [PDF]
PLoS ONE, 2015 Translocation to the nucleus of diacylglycerol kinase (DGK)- ζ is dependent on a sequence homologous to the effector domain of Myristoylated Alanine Rich C-Kinase Substrate (MARCKS). These data would suggest that MARCKS could also localize to the nucleus.
Timothy D Rohrbach +11 more
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The N-terminal 33 amino acid domain of Siva-1 is sufficient for nuclear localization
Brazilian Journal of Medical and Biological Research, 2013 Siva-1 induces apoptosis in multiple pathological processes and plays an important role in the suppression of tumor metastasis, protein degradation, and other functions.
J.Y. Chen, L.X. Yang, Z.F. Huang
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Identification of a classical bipartite nuclear localization signal in the Drosophila TEA/ATTS protein scalloped. [PDF]
PLoS ONE, 2011 Drosophila melanogaster wing development has been shown to rely on the activity of a complex of two proteins, Scalloped (Sd) and Vestigial (Vg). Within this complex, Sd is known to provide DNA binding though its TEA/ATTS domain, while Vg modulates this ...
Adam C Magico, John B Bell
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RAM function is dependent on Kapβ2-mediated nuclear entry [PDF]
, 2014 Eukaryotic gene expression is dependent on the modification of the first transcribed nucleotide of pre-mRNA by the addition of the 7-methylguanosine cap.
Gonatopoulos-Pournatzis, Thomas +1 more
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PLoS ONE, 2015 The Ran GTPase activating protein RanGAP1 plays an essential role in nuclear transport by stimulating RanGTP hydrolysis in the cytoplasmic compartment.
Keith Cha +3 more
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Differential recognition of canonical NF-κB dimers by Importin α3
Nature Communications, 2022 Nuclear translocation of the p50/p65 heterodimer is essential for NF-κB signaling. Here, the authors identify a bipartite Nuclear Localization Signal in the NF-κB p50/p65 heterodimer that is recognized with high affinity by importin α3.
Tyler J. Florio +6 more
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The A78V mutation in the Mad3-like domain of Schizosaccharomyces pombe Bub1p perturbs nuclear accumulation and kinetochore targeting of Bub1p, Bub3p, and Mad3p and spindle assembly checkpoint function [PDF]
, 2005 During mitosis, the spindle assembly checkpoint (SAC) responds to faulty attachments between kinetochores and the mitotic spindle by imposing a metaphase arrest until the defect is corrected, thereby preventing chromosome missegregation. A genetic screen
Vanoosthuyse, V. +6 more
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