Parafibromin is a nuclear protein with a functional monopartite nuclear localization signal [PDF]
Oncogene, 2006 Parafibromin is a nuclear protein with a tumour suppressor role in the development of non-hereditary and hereditary parathyroid carcinomas, and the hyperparathyroidism-jaw tumour (HPT-JT) syndrome, which is associated with renal and uterine tumours. Nuclear localization signal(s), (NLS(s)), of the 61 kDa parafibromin remain to be defined.
Bradley, K +8 more
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Subdomain-specific localization of CLIMP-63 (p63) in the endoplasmic reticulum is mediated by its luminal alpha-helical segment [PDF]
, 2001 The microtubule-binding integral 63 kD cytoskeleton-linking membrane protein (CLIMP-63; former name, p63) of the rough endoplasmic reticulum (ER) is excluded from the nuclear envelope.
Klopfenstein, D. R. +17 more
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Identification of a functional nuclear localization signal mediating nuclear import of the zinc finger transcription factor ZNF24. [PDF]
PLoS ONE, 2013 ZNF24 is a member of the SCAN domain family of Krüppel-like zinc finger (ZF) transcription factors, which plays a critical role in cell proliferation and differentiation.
Jian-Zhong Li +9 more
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Regulation of Nuclear Localization during Signaling [PDF]
Journal of Biological Chemistry, 2001 Signaling pathways consist of a chain of biochemical events thatform the intracellular equivalent of a fire bucket brigade. An initialchange or chemical signal outside the cell is sensed at the cellsurface by a receptor, which then transduces the signal to thecytosol.
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Regulation of Nuclear Import by Phosphorylation Adjacent to Nuclear Localization Signals [PDF]
Journal of Biological Chemistry, 2004 Many important regulatory proteins, including cell cycle regulators and transcription factors, contain a phosphorylation site within or adjacent to a classic nuclear localization signal (NLS) sequence. Previous studies show that the nuclear localization of these cargoes can be regulated by phosphorylation at these sites.
Michelle T, Harreman +5 more
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Nuclear localization is required for Dishevelled function in Wnt/β-catenin signaling
Journal of Biology, 2005 Background Dishevelled (Dsh) is a key component of multiple signaling pathways that are initiated by Wnt secreted ligands and Frizzled receptors during embryonic development.
Sokol Sergei Y +4 more
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Analysis of Domains Affecting Intracellular Localization of the FMRP Protein
Neurobiology of Disease, 1997 Fragile X syndrome is the most frequent form of inherited mental retardation and it is caused by deficiency of FMRP, the protein encoded by the FMR1 gene. FMRP is a RNA binding protein of unknown function which is associated with ribosomes. FMRP is found
B. Bardoni +3 more
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A nuclear localization signal binding protein in the nucleolus. [PDF]
The Journal of cell biology, 1990 We used functional wild-type and mutant synthetic nuclear localization signal peptides of SV-40 T antigen cross-linked to human serum albumin (peptide conjugates) to assay their binding to proteins of rat liver nuclei on Western blots. Proteins of 140 and 55 kD (p140 and p55) were exclusively recognized by wild-type peptide conjugates.
U T, Meier, G, Blobel
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Mediated nuclear import and export of TAZ and the underlying molecular requirements
Nature Communications, 2018 The transcriptional co-factors Yap and TAZ are regulated by Hippo signalling and mechanical forces via their nucleocytoplasmic shuttling. Here the authors identify a RhoA-regulated C-terminal nuclear localization signal and a TEAD-regulated N-terminal ...
Michael Kofler +5 more
doaj +1 more source
Nuclear Import and Export Signals of Human Cohesins SA1/STAG1 and SA2/STAG2 Expressed in Saccharomyces cerevisiae [PDF]
, 2012 Background: Human SA/STAG proteins, homologues of the yeast Irr1/Scc3 cohesin, are the least studied constituents of the sister chromatid cohesion complex crucial for proper chromosome segregation.
Jurek, Marta +27 more
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