Characterization of Ku70(2)-NLS as bipartite nuclear localization sequence for non-viral gene delivery. [PDF]
, 2012 Several barriers have to be overcome in order to achieve gene expression in target cells, e.g. cellular uptake, endosomal release and translocation to the nucleus.
Maucksch, Christof +17 more
core +1 more source
The role of nuclear localization signal in parvovirus life cycle
Virology Journal, 2017 Parvoviruses are small, non-enveloped viruses with an approximately 5.0 kb, single-stranded DNA genome. Usually, the parvovirus capsid gene contains one or more nuclear localization signals (NLSs), which are required for guiding the virus particle into ...
Peng Liu +3 more
doaj +1 more source
Cooperative nuclear localization sequences lend a novel role to the N-terminal region of MSH6. [PDF]
PLoS ONE, 2011 Human mismatch repair proteins MSH2-MSH6 play an essential role in maintaining genetic stability and preventing disease. While protein functions have been extensively studied, the substantial amino-terminal region (NTR*) of MSH6 that is unique to ...
Natalie R Gassman +5 more
doaj +1 more source
Data on dimer formation between importin α subtypes
Data in Brief, 2016 This article describes data related to the research article titled “Functional characterization of importin α8 as a classical nuclear localization signal receptor” [1].
Yoichi Miyamoto, Masahiro Oka
doaj +1 more source
Data for: Nuclear localization signal regulates Porcine Circovirus type 2 Capsid protein nuclear export through phosphorylation [PDF]
, 2018 Data for: Nuclear localization signal regulates Porcine Circovirus type 2 Capsid protein nuclear export through ...
Xiaoyu Guo (280620) +7 more
core +3 more sources
The Effector Domain of MARCKS Is a Nuclear Localization Signal that Regulates Cellular PIP2 Levels and Nuclear PIP2 Localization. [PDF]
PLoS ONE, 2015 Translocation to the nucleus of diacylglycerol kinase (DGK)- ζ is dependent on a sequence homologous to the effector domain of Myristoylated Alanine Rich C-Kinase Substrate (MARCKS). These data would suggest that MARCKS could also localize to the nucleus.
Timothy D Rohrbach +11 more
doaj +1 more source
Differential recognition of canonical NF-κB dimers by Importin α3
Nature Communications, 2022 Nuclear translocation of the p50/p65 heterodimer is essential for NF-κB signaling. Here, the authors identify a bipartite Nuclear Localization Signal in the NF-κB p50/p65 heterodimer that is recognized with high affinity by importin α3.
Tyler J. Florio +6 more
doaj +1 more source
Tissue- and developmental stage-specific changes in the subcellular localization of the 26S proteasome in the ovary of Drosophila melanogaster [PDF]
, 2004 The intracellular localization of the 26S proteasome in the different ovarian cell types of Drosophila melanogaster was studied by means of immunofluorescence staining and laser scanning microscopy, with the use of antibodies specific for regulatory ...
Andó, István +5 more
core +1 more source
The N-terminal 33 amino acid domain of Siva-1 is sufficient for nuclear localization
Brazilian Journal of Medical and Biological Research, 2013 Siva-1 induces apoptosis in multiple pathological processes and plays an important role in the suppression of tumor metastasis, protein degradation, and other functions.
J.Y. Chen, L.X. Yang, Z.F. Huang
doaj +1 more source
RAM function is dependent on Kapβ2-mediated nuclear entry [PDF]
, 2014 Eukaryotic gene expression is dependent on the modification of the first transcribed nucleotide of pre-mRNA by the addition of the 7-methylguanosine cap.
Gonatopoulos-Pournatzis, Thomas +1 more
core +1 more source