Results 11 to 20 of about 332,213 (303)
Poultry Science, 2021 Duck enteritis virus (DEV) multifunctional tegument protein UL13 is predicted to be a conserved herpesvirus protein kinase; however, little is known about its subcellular localization signal.
Linjiang Yang +23 more
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Types of nuclear localization signals and mechanisms of protein import into the nucleus
Cell Communication and Signaling, 2021 Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment that mediates the transport of proteins from the cytoplasm into the nucleus.
Juane Lu +6 more
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Biology Direct, 2020 Background The origin of the selective nuclear protein import machinery, which consists of nuclear pore complexes and adaptor molecules interacting with the nuclear localization signals (NLSs) of cargo molecules, is one of the most important events in ...
Olga M. Lisitsyna +6 more
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NLSdb: database of nuclear localization signals [PDF]
Nucleic Acids Research, 2003 NLSdb is a database of nuclear localization signals (NLSs) and of nuclear proteins. NLSs are short stretches of residues mediating transport of nuclear proteins into the nucleus. The database contains 114 experimentally determined NLSs that were obtained through an extensive literature search.
Rajesh Nair, Phil Carter, Burkhard Rost
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Nuclear export of L-periaxin, mediated by its nuclear export signal in the PDZ domain. [PDF]
PLoS ONE, 2014 Myelinating Schwann cells specifically express L-periaxin (L-PRX) in the mammalian peripheral nervous system. Several loss-of-function mutations in periaxin have been described and linked to autosomal recessive Dejerine Sottas neuropathy and to ...
Yawei Shi, Lei Zhang, Ting Yang
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Functional dissection of N-terminal nuclear trafficking signals of SETDB1
Frontiers in Cell and Developmental Biology, 2022 SETDB1 is a histone H3-lysine 9-specific methyltransferase that fulfills epigenetic functions inside the nucleus; however, when overexpressed, SETDB1 majorily localizes in the cytoplasm. SETDB1 has a single nuclear-localization-signal (NLS) motif and two
Jaemin Eom +6 more
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Nonclassical nuclear localization signals mediate nuclear import of CIRBP [PDF]
Proceedings of the National Academy of Sciences, 2020 Significance We uncovered a molecular mechanism by which multiple importins regulate nuclear import, phase separation, and stress granule recruitment of an RNA-binding protein. Our work permitted the identification of two types of nuclear localization signal (NLS) in cold-inducible RNA-binding protein (CIRBP).
Benjamin Bourgeois +11 more
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Mechanisms of GnRH-induced extracellular signal-regulated kinase nuclear localization. [PDF]
PLoS ONE, 2012 Gonadotropin-releasing hormone receptors (GnRHR) mediate activation and nuclear translocation of the extracellular signal regulated kinases 1 and 2 (ERK) by phosphorylation on the TEY motif.
Christopher J Caunt +3 more
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Cooperative nuclear localization sequences lend a novel role to the N-terminal region of MSH6. [PDF]
PLoS ONE, 2011 Human mismatch repair proteins MSH2-MSH6 play an essential role in maintaining genetic stability and preventing disease. While protein functions have been extensively studied, the substantial amino-terminal region (NTR*) of MSH6 that is unique to ...
Natalie R Gassman +5 more
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Characterization of Ku70(2)-NLS as bipartite nuclear localization sequence for non-viral gene delivery. [PDF]
, 2012 Several barriers have to be overcome in order to achieve gene expression in target cells, e.g. cellular uptake, endosomal release and translocation to the nucleus.
Maucksch, Christof +17 more
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