Passive nuclear transport deviates from Fickian behavior in prostate and breast cell types [PDF]
NucleusNuclear trafficking is essential for cellular function and biomedical applications such as nucleus-targeted drug delivery; however, how passive nuclear transport varies across cell types and phenotypic states remains poorly understood.
Nicholas R. Scott +3 more
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Kap-β2/Transportin mediates β-catenin nuclear transport in Wnt signaling [PDF]
eLife, 2022 Wnt signaling is essential for many aspects of embryonic development including the formation of the primary embryonic axis. In addition, excessive Wnt signaling drives multiple diseases including cancer, highlighting its importance for disease ...
Woong Y Hwang +4 more
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Nuclear transport proteins: structure, function and disease relevance [PDF]
Signal Transduction and Targeted Therapy, 2023 Proper subcellular localization is crucial for the functioning of biomacromolecules, including proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the localization of many macromolecules within the nuclear or cytoplasmic
Yang Yang +5 more
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Nuclear Transport of Yeast Proteasomes
Biomolecules, 2014 Proteasomes are conserved protease complexes enriched in the nuclei of dividing yeast cells, a major site for protein degradation. If yeast cells do not proliferate and transit to quiescence, metabolic changes result in the dissociation of proteasomes ...
Cordula Enenkel
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Controlling the Gatekeeper: Therapeutic Targeting of Nuclear Transport
Cells, 2018 Nuclear transport receptors of the karyopherin superfamily of proteins transport macromolecules from one compartment to the other and are critical for both cell physiology and pathophysiology.
Friederike K. Kosyna, Reinhard Depping
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Gene alterations in the nuclear transport receptor superfamily: A study of head and neck cancer. [PDF]
PLoS ONEIn cancer cells, the nuclear transport system is often disrupted, leading to abnormal localization of nuclear proteins and altered gene expression.
Phuong Thao Nguyen +6 more
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The Ebola Virus Interferon Antagonist VP24 Undergoes Active Nucleocytoplasmic Trafficking
Viruses, 2021 Viral interferon (IFN) antagonist proteins mediate evasion of IFN-mediated innate immunity and are often multifunctional, with distinct roles in viral replication.
Angela R. Harrison +3 more
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The Nuclear Transport Protein Importin-5: A Promising Target in Oncology and Virology
CHIMIA, 2021 Cellular homeostasis importantly relies on the correct nucleoplasmic distribution of a large number of RNA molecules and proteins, which are shuttled by specialized transport receptors.
Rémi Patouret
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Nuclear Transporter IPO13 Is Central to Efficient Neuronal Differentiation
Cells, 2022 Molecular transport between the nucleus and cytoplasm of the cell is mediated by the importin superfamily of transport receptors, of which the bidirectional transporter Importin 13 (IPO13) is a unique member, with a critical role in early embryonic ...
Katarzyna A. Gajewska +2 more
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Non-transport roles of nuclear import receptors: In need of the right balance
Frontiers in Cell and Developmental Biology, 2022 Nuclear import receptors ensure the recognition and transport of proteins across the nuclear envelope into the nucleus. In addition, as diverse processes as mitosis, post-translational modifications at mitotic exit, ciliogenesis, and phase separation ...
Michela Damizia +4 more
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