Nuclear transport proteins: structure, function, and disease relevance. [PDF]
Signal Transduct Target Ther, 2023 Proper subcellular localization is crucial for the functioning of biomacromolecules, including proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the localization of many macromolecules within the nuclear or cytoplasmic
Yang Y +5 more
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Passive nuclear transport deviates from Fickian behavior in prostate and breast cell types. [PDF]
NucleusNuclear trafficking is essential for cellular function and biomedical applications such as nucleus-targeted drug delivery; however, how passive nuclear transport varies across cell types and phenotypic states remains poorly understood.
Scott NR, Lin AJ, Belardi B, Parekh SH.
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Kap-β2/Transportin mediates β-catenin nuclear transport in Wnt signaling. [PDF]
Elife, 2022 Wnt signaling is essential for many aspects of embryonic development including the formation of the primary embryonic axis. In addition, excessive Wnt signaling drives multiple diseases including cancer, highlighting its importance for disease ...
Hwang WY +4 more
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Gene alterations in the nuclear transport receptor superfamily: A study of head and neck cancer. [PDF]
PLoS OneIn cancer cells, the nuclear transport system is often disrupted, leading to abnormal localization of nuclear proteins and altered gene expression.
Nguyen PT +6 more
europepmc +2 more sources
The Ebola Virus Interferon Antagonist VP24 Undergoes Active Nucleocytoplasmic Trafficking
Viruses, 2021 Viral interferon (IFN) antagonist proteins mediate evasion of IFN-mediated innate immunity and are often multifunctional, with distinct roles in viral replication.
Angela R. Harrison +3 more
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The Nuclear Transport Protein Importin-5: A Promising Target in Oncology and Virology
CHIMIA, 2021 Cellular homeostasis importantly relies on the correct nucleoplasmic distribution of a large number of RNA molecules and proteins, which are shuttled by specialized transport receptors.
Rémi Patouret
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Nuclear Transporter IPO13 Is Central to Efficient Neuronal Differentiation
Cells, 2022 Molecular transport between the nucleus and cytoplasm of the cell is mediated by the importin superfamily of transport receptors, of which the bidirectional transporter Importin 13 (IPO13) is a unique member, with a critical role in early embryonic ...
Katarzyna A. Gajewska +2 more
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Non-transport roles of nuclear import receptors: In need of the right balance
Frontiers in Cell and Developmental Biology, 2022 Nuclear import receptors ensure the recognition and transport of proteins across the nuclear envelope into the nucleus. In addition, as diverse processes as mitosis, post-translational modifications at mitotic exit, ciliogenesis, and phase separation ...
Michela Damizia +4 more
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Consequence prediction in nuclear transport explosion accident using long short-term memory network
Fushe yanjiu yu fushe gongyi xuebao, 2023 During the transportation of components related to nuclear materials, accidental chemical explosions may occur, resulting in the release of radionuclides.
RUAN Lingpan +5 more
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Frontiers in Immunology, 2023 The Th17+ arrangement is critical for orchestrating both innate and acquired immune responses. In this context, the serum and glucocorticoid regulated kinase 1 (SGK1) exerts a key role in the governance of IL-23R-dependent Th17+ maturation, through the ...
Carolina Brescia +19 more
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