Results 31 to 40 of about 456,044 (305)
A system-wide mislocalization of RNA-binding proteins in motor neurons is a new feature of ALS
Neurobiology of Disease, 2021 Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by progressive degeneration of motor neurons. Mislocalization of TAR DNA-binding protein 43 (TDP-43) is an early event in the formation of cytoplasmic TDP-43-positive inclusions ...
Yu-Ju Liu, Hung-Chih Kuo, Yijuang Chern
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eLife, 2021 The nuclear pore complex (NPC) is the sole and selective gateway for nuclear transport, and its dysfunction has been associated with many diseases. The metazoan NPC subcomplex RanBP2, which consists of RanBP2 (Nup358), RanGAP1-SUMO1, and Ubc9, regulates ...
Yujiao He +10 more
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Cell, 2007 I Kap95 Kap60 adaptor for cNLS proteins Yes Importin-b1 Importin-a adaptor for cNLS proteins, Snurportin adaptor for U snRNPsII Kap95 — Yes Importin-b1 SREBP-2, HIV Rev and TAT, Cyclin BKap104 Nab2, Hrp1 (mRNA-binding proteins)t.s. Transportin or Transportin 2PY-NLS-containing proteins, mRNA-binding proteins, histones, ribosomal proteinsKap123 SRP ...
Tran, Elizabeth J. +2 more
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HEPATITIS C VIRUS AND HOST CELL NUCLEAR TRANSPORT MACHINERY: A CLANDESTINE AFFAIR
Frontiers in Microbiology, 2015 There is growing evidence that factors encoded by cytoplasmic replicating viruses functionally interact with components of the nucleocytoplasmic transport apparatus.
Barbara eBonamassa +5 more
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The Tau of Nuclear-Cytoplasmic Transport [PDF]
Neuron, 2018 Aggregation of microtubule-associated protein tau is the hallmark of tauopathies, including Alzheimer's disease. Eftekharzadeh et al. (2018) demonstrate that pathogenic tau alters nucleocytoplasmic transport by interacting with components of the nuclear pore complex, revealing a perturbation shared by multiple neurodegenerative diseases.
Evan, Lester, Roy, Parker
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Nuclear Localization Signals for Optimization of Genetically Encoded Tools in Neurons
Frontiers in Cell and Developmental Biology, 2022 Nuclear transport in neurons differs from that in non-neuronal cells. Here we developed a non-opsin optogenetic tool (OT) for the nuclear export of a protein of interest induced by near-infrared (NIR) light.
Maksim M. Karasev +4 more
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Characterization of Ku70(2)-NLS as bipartite nuclear localization sequence for non-viral gene delivery. [PDF]
, 2012 Several barriers have to be overcome in order to achieve gene expression in target cells, e.g. cellular uptake, endosomal release and translocation to the nucleus.
Maucksch, Christof +17 more
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Structural Basis of Targeting the Exportin CRM1 in Cancer
Cells, 2015 Recent studies have demonstrated the interference of nucleocytoplasmic trafficking with the establishment and maintenance of various cancers. Nucleocytoplasmic transport is highly regulated and coordinated, involving different nuclear transport factors ...
Achim Dickmanns +2 more
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Molecular determinants of large cargo transport into the nucleus
eLife, 2020 Nucleocytoplasmic transport is tightly regulated by the nuclear pore complex (NPC). Among the thousands of molecules that cross the NPC, even very large (>15 nm) cargoes such as pathogens, mRNAs and pre-ribosomes can pass the NPC intact.
Giulia Paci +4 more
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NDC1 : a crucial membrane-integral nucleoporin of metazoan nuclear pore complexes [PDF]
, 2006 POM121 and gp210 were, until this point, the only known membrane-integral nucleoporins (Nups) of vertebrates and, thus, the only candidate anchors for nuclear pore complexes (NPCs) within the nuclear membrane. In an accompanying study (Stavru et al.), we
Gorlich, D. +20 more
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