Results 31 to 40 of about 411,090 (114)

Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects

BMC Genomics, 2021
Background The nuclear transport machinery is involved in a well-known male meiotic drive system in Drosophila. Fast gene evolution and gene duplications have been major underlying mechanisms in the evolution of meiotic drive systems, and this might ...
Ayda Mirsalehi, Dragomira N. Markova, Mohammadmehdi Eslamieh, Esther Betrán   +3 more
doaj   +1 more source

Structural determinants of nuclear export signal orientation in binding to exportin CRM1

eLife, 2015
The Chromosome Region of Maintenance 1 (CRM1) protein mediates nuclear export of hundreds of proteins through recognition of their nuclear export signals (NESs), which are highly variable in sequence and structure.
Ho Yee Joyce Fung, Szu-Chin Fu, Chad A Brautigam, Yuh Min Chook   +3 more
doaj   +1 more source

Nuclear Import of Hepatitis B Virus Capsids and Genome

Viruses, 2017
Hepatitis B virus (HBV) is an enveloped pararetrovirus with a DNA genome, which is found in an up to 36 nm-measuring capsid. Replication of the genome occurs via an RNA intermediate, which is synthesized in the nucleus.
Lara Gallucci, Michael Kann
doaj   +1 more source

The nuclear envelope and nuclear pore complexes in neurodegenerative diseases

Frontiers in Cell and Developmental Biology
The nuclear envelope (NE) and nuclear pore complexes (NPCs) play a critical role in maintaining the balance between the nucleus and cytoplasm, which is essential for the structural integrity and gene regulatory functions of eukaryotic cells.
Tingyan Wu, Tingyan Wu, Haochen Xu, Haochen Xu, Lei Cheng, Lei Cheng, Ruoxin Wu, Ruoxin Wu, Fuzheng Guo, Xi Chen, Xi Chen   +10 more
doaj   +1 more source

Variation in the nuclear effects of infection by different human rhinovirus serotypes.

Frontiers in Microbiology, 2015
Human rhinovirus (HRV) is a positive sense RNA virus, which, despite replicating in the cytoplasm, has a significant impact on nuclear transport and nuclear localisation of host proteins.
Erin Joanne Walker, Lora M Jensen, Sarah N Croft, Reena eGhildyal   +3 more
doaj   +1 more source

Respiratory virus modulation of host nucleocytoplasmic transport; target for therapeutic intervention?

Frontiers in Microbiology, 2015
The respiratory diseases caused by Rhinovirus, Respiratory Syncytial Virus and Influenza virus represent a large social and financial burden on healthcare worldwide.
Leon eCaly, Reena eGhildyal, David Andrew Jans   +2 more
doaj   +1 more source

Controlling the Gatekeeper: Therapeutic Targeting of Nuclear Transport

Cells, 2018
Nuclear transport receptors of the karyopherin superfamily of proteins transport macromolecules from one compartment to the other and are critical for both cell physiology and pathophysiology.
Friederike K. Kosyna, Reinhard Depping
doaj   +1 more source

The Potential of Nuclear Pore Complexes in Cancer Therapy

Molecules
Nuclear pore complexes (NPCs) play a critical role in regulating transport-dependent gene expression, influencing various stages of cancer development and progression.
Hanna Zaitsava, Martyna Gachowska, Elżbieta Bartoszewska, Alicja Kmiecik, Julita Kulbacka   +4 more
doaj   +1 more source

Neglected Issues in T Lymphocyte Metabolism: Purine Metabolism and Control of Nuclear Envelope Regulatory Processes. New Insights into Triggering Potential Metabolic Fragilities

Immuno
The metabolism of T-lymphocytes has recently emerged as a pivotal area of investigation, offering insights into the supra-genic modulations that can influence the genetic mechanisms underlying lymphocyte clustering processes. Furthermore, it has become a
Naomi Torchia, Carolina Brescia, Emanuela Chiarella, Salvatore Audia, Francesco Trapasso, Rosario Amato   +5 more
doaj   +1 more source

An ESCRT-LEM protein surveillance system is poised to directly monitor the nuclear envelope and nuclear transport system

eLife, 2019
The integrity of the nuclear membranes coupled to the selective barrier of nuclear pore complexes (NPCs) are essential for the segregation of nucleoplasm and cytoplasm.
David J Thaller, Matteo Allegretti, Sapan Borah, Paolo Ronchi, Martin Beck, C Patrick Lusk   +5 more
doaj   +1 more source