Results 11 to 20 of about 411,090 (114)
Visualizing the disordered nuclear transport machinery in situ. [PDF]
Nature, 2023 Yu M +11 more
europepmc +2 more sources
Extensive cargo identification reveals distinct biological roles of the 12 importin pathways
eLife, 2017 Vast numbers of proteins are transported into and out of the nuclei by approximately 20 species of importin-β family nucleocytoplasmic transport receptors.
Makoto Kimura +5 more
doaj +1 more source
The Role of Protein Disorder in Nuclear Transport and in Its Subversion by Viruses
Cells, 2020 The transport of host proteins into and out of the nucleus is key to host function. However, nuclear transport is restricted by nuclear pores that perforate the nuclear envelope.
Jacinta M. Wubben +2 more
doaj +1 more source
Structure-based nuclear import mechanism of histones H3 and H4 mediated by Kap123
eLife, 2017 Kap123, a major karyopherin protein of budding yeast, recognizes the nuclear localization signals (NLSs) of cytoplasmic histones H3 and H4 and translocates them into the nucleus during DNA replication.
Sojin An +4 more
doaj +1 more source
G3: Genes, Genomes, Genetics, 2016 Protein transport between the nucleus and cytoplasm of eukaryotic cells is tightly regulated, providing a mechanism for controlling intracellular localization of proteins, and regulating gene expression. In this study, we have investigated the importance
Kenneth D. Belanger +4 more
doaj +1 more source
Arabidopsis FHY1 and FHY1-LIKE Are Not Required for Phytochrome A Signal Transduction in the Nucleus
Plant Communications, 2020 Photoreceptors of the phytochrome family control a multitude of responses in plants. Phytochrome A (phyA) is essential for far-red light perception, which is important for germination and seedling establishment in strong canopy shade.
Chiara Menon +2 more
doaj +1 more source
Parallel import mechanisms ensure the robust nuclear localization of actin in Drosophila
Frontiers in Molecular Biosciences, 2022 Actin, as an ancient and fundamental protein, participates in various cytoplasmic as well as nuclear functions in eukaryotic cells. Based on its manifold tasks in the nucleus, it is a reasonable assumption that the nuclear presence of actin is essential ...
Péter Borkúti +11 more
doaj +1 more source
Differential Behaviours and Preferential Bindings of Influenza Nucleoproteins on Importins-α
Viruses, 2020 Influenza viruses are negative single-stranded RNA viruses with nuclear transcription and replication. They enter the nucleus by using the cellular importin-α/-β nuclear import machinery.
Amélie Donchet +4 more
doaj +1 more source
Cell Reports, 2020 Summary: The nuclear pore complex forms a highly crowded selective barrier with intrinsically disordered regions at the nuclear membrane to coordinate nucleocytoplasmic molecular communications.
Wanzhen Zhang +5 more
doaj +1 more source
A system-wide mislocalization of RNA-binding proteins in motor neurons is a new feature of ALS
Neurobiology of Disease, 2021 Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by progressive degeneration of motor neurons. Mislocalization of TAR DNA-binding protein 43 (TDP-43) is an early event in the formation of cytoplasmic TDP-43-positive inclusions ...
Yu-Ju Liu, Hung-Chih Kuo, Yijuang Chern
doaj +1 more source