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Nuclear Transport: Beginning to Gel? [PDF]
Current Biology, 2012 The massive nuclear pore complex mediates nucleocytoplasmic traffic ranging from a single histone to a viral genome. To date, dissecting mechanism has been more an exercise in prediction than biochemical certainty. A recent study combines recombinant proteins with nuclei reconstituted in vitro to test predictions in a startlingly productive manner.
Powers, Maureen A. +1 more
openaire +2 more sources
Distinct RanBP1 nuclear export and cargo dissociation mechanisms between fungi and animals
eLife, 2019 Ran binding protein 1 (RanBP1) is a cytoplasmic-enriched and nuclear-cytoplasmic shuttling protein, playing important roles in nuclear transport. Much of what we know about RanBP1 is learned from fungi. Intrigued by the long-standing paradox of harboring
Yuling Li +9 more
doaj +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Active Nuclear Import of Membrane Proteins Revisited
Cells, 2015 It is poorly understood how membrane proteins destined for the inner nuclear membrane pass the crowded environment of the Nuclear Pore Complex (NPC). For the Saccharomyces cerevisiae proteins Src1/Heh1 and Heh2, a transport mechanism was proposed where ...
Justyna K. Laba +5 more
doaj +1 more source
Nuclear Transport of Yeast Proteasomes [PDF]
Frontiers in Molecular Biosciences, 2019 Proteasomes are key proteases in regulating protein homeostasis. Their holo-enzymes are composed of 40 different subunits which are arranged in a proteolytic core (CP) flanked by one to two regulatory particles (RP). Proteasomal proteolysis is essential for the degradation of proteins which control time-sensitive processes like cell cycle progression ...
Wendler, Petra (Prof. Dr.) +1 more
openaire +4 more sources
Organellar proteomics: the prizes and pitfalls of opening the nuclear envelope [PDF]
, 2002 Proteomic studies have the potential to comprehensively define the composition of organelles but are limited by the organellar cross-contamination that arises during subcellular fractionation.
Gerace, Larry, Schirmer, Eric C
core +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Nuclear Pores: David and Goliath in nuclear transport [PDF]
Current Biology, 1995 AbstractThe small GTP-binding protein Ran has been implicated in protein import into, and mRNA export from, the nucleus. A recently identified ‘giant’ nuclear pore complex protein, Nup358, binds GTP–Ran.
openaire +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
"Influences on European Union Nuclear Waste Transport Policy" [PDF]
, 1995 This paper identifies the evolution of pro- and anti-nuclear advocacy coalitions to their incorporation of the shipments issue in the late 1980's. The pro-nuclear waste transport advocacy coalition has come to include developed nuclear powers, such as ...
Anglim, Jennifer +2 more
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