Nuclear export of L-periaxin, mediated by its nuclear export signal in the PDZ domain. [PDF]
PLoS ONE, 2014 Myelinating Schwann cells specifically express L-periaxin (L-PRX) in the mammalian peripheral nervous system. Several loss-of-function mutations in periaxin have been described and linked to autosomal recessive Dejerine Sottas neuropathy and to ...
Yawei Shi, Lei Zhang, Ting Yang
doaj +6 more sources
A nuclear export signal in hnRNP A1: A signal-mediated, temperature-dependent nuclear protein export pathway [PDF]
Cell, 1995 Pre-mRNAs are associated with hnRNPs, and these proteins play important roles in the biogenesis of mRNAs. The hnRNP A1 is one of the most abundant hnRNPs, and although localized primarily in the nucleoplasm, shuttles continuously between the nucleus and ...
Dreyfuss, Gideon +2 more
core +3 more sources
Protocol for nuclear export signal characterization of cGAS in mammalian cells [PDF]
STAR Protocols, 2021 Summary: The cyclic GMP-AMP synthase (cGAS) is the principal DNA sensor, which binds DNA and triggers the type I interferon production. We used ISD45 or inactivated Vaccinia Virus (VACV) to stimulate cGAS and monitored cellular localization by ...
Yu Huang +3 more
doaj +2 more sources
Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis. [PDF]
Cancer Discov, 2019 Altered expression of XPO1, the main nuclear export receptor in eukaryotic cells, has been observed in cancer and XPO1 has been a focus of anti-cancer drug development.
Taylor J +26 more
europepmc +6 more sources
The signal sequence coding region promotes nuclear export of mRNA. [PDF]
PLoS Biology, 2007 In eukaryotic cells, most mRNAs are exported from the nucleus by the transcription export (TREX) complex, which is loaded onto mRNAs after their splicing and capping.
Alexander F Palazzo +5 more
doaj +3 more sources
Nuclear Export Signal Masking Regulates HIV-1 Rev Trafficking and Viral RNA Nuclear Export. [PDF]
Journal of Virology, 2017 ABSTRACT HIV-1's Rev protein forms a homo-oligomeric adaptor complex linking viral RNAs to the cellular CRM1/Ran-GTP nuclear export machinery through the activity of Rev's prototypical leucine-rich nuclear export signal (NES). In this study, we used a functional fluorescently tagged Rev fusion protein as a platform to study the effects of ...
Nathan M. Sherer +2 more
exaly +5 more sources
A supraphysiological nuclear export signal is required for parvovirus nuclear export [PDF]
Molecular Biology of the Cell, 2008 CRM1 exports proteins that carry a short leucine-rich peptide signal, the nuclear export signal (NES), from the nucleus. Regular NESs must have low affinity for CRM1 to function optimally.
Valle, Noelia +5 more
core +5 more sources
Structural determinants of nuclear export signal orientation in binding to exportin CRM1 [PDF]
eLife, 2015 The Chromosome Region of Maintenance 1 (CRM1) protein mediates nuclear export of hundreds of proteins through recognition of their nuclear export signals (NESs), which are highly variable in sequence and structure.
Ho Yee Joyce Fung +3 more
doaj +2 more sources
A TFEB nuclear export signal integrates amino acid supply and glucose availability [PDF]
Nature Communications, 2018 On amino acid deprivation TFEB translocates from the cytoplasm to the nucleus. Here the authors identify a nuclear export signal in TFEB that requires dual phosphorylation at the S142 ERK/mTORC1 and S138 GSK3β sites, and further show glucose limitation ...
Linxin Li +10 more
doaj +2 more sources
Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals
eLife, 2017 Nuclear export receptor CRM1 binds highly variable nuclear export signals (NESs) in hundreds of different cargoes. Previously we have shown that CRM1 binds NESs in both polypeptide orientations (Fung et al., 2015).
Ho Yee Joyce Fung +2 more
doaj +3 more sources