Results 1 to 10 of about 73,362 (284)
Nuclear export of L-periaxin, mediated by its nuclear export signal in the PDZ domain. [PDF]
PLoS ONE, 2014 Myelinating Schwann cells specifically express L-periaxin (L-PRX) in the mammalian peripheral nervous system. Several loss-of-function mutations in periaxin have been described and linked to autosomal recessive Dejerine Sottas neuropathy and to ...
Yawei Shi, Lei Zhang, Ting Yang
doaj +7 more sources
FAK nuclear export signal sequences [PDF]
FEBS Letters, 2008 Ubiquitously expressed focal adhesion kinase (FAK), a critical component in transducing signals from sites of cell contacts with extracellular matrix, was named after its typical localization in focal adhesions. A nuclear localization of FAK has been also reported and its scaffolding role in nucleus and requirement for p53 ubiquitination were only ...
Ssang-Taek Steve Lim, Dusko Ilić
exaly +5 more sources
Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis. [PDF]
Cancer Discov, 2019 Abstract Altered expression of XPO1, the main nuclear export receptor in eukaryotic cells, has been observed in cancer, and XPO1 has been a focus of anticancer drug development. However, mechanistic evidence for cancer-specific alterations in XPO1 function is lacking. Here, genomic analysis of
Taylor J +26 more
europepmc +8 more sources
Nuclear Export Signal Masking Regulates HIV-1 Rev Trafficking and Viral RNA Nuclear Export [PDF]
Journal of Virology, 2017 ABSTRACT HIV-1's Rev protein forms a homo-oligomeric adaptor complex linking viral RNAs to the cellular CRM1/Ran-GTP nuclear export machinery through the activity of Rev's prototypical leucine-rich nuclear export signal (NES). In this study, we used a functional fluorescently tagged Rev fusion protein as a platform to study the effects of ...
Nathan Sherer +2 more
exaly +5 more sources
A TFEB nuclear export signal integrates amino acid supply and glucose availability [PDF]
Nature Communications, 2018 On amino acid deprivation TFEB translocates from the cytoplasm to the nucleus. Here the authors identify a nuclear export signal in TFEB that requires dual phosphorylation at the S142 ERK/mTORC1 and S138 GSK3β sites, and further show glucose limitation ...
Linxin Li +10 more
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Protocol for nuclear export signal characterization of cGAS in mammalian cells [PDF]
STAR Protocols, 2021 Summary: The cyclic GMP-AMP synthase (cGAS) is the principal DNA sensor, which binds DNA and triggers the type I interferon production. We used ISD45 or inactivated Vaccinia Virus (VACV) to stimulate cGAS and monitored cellular localization by ...
Yu Huang +3 more
doaj +2 more sources
Frontiers in Microbiology, 2022 The nuclear localization signal (NLS) and nuclear export signal (NES) are key signatures of proteins for controlling nuclear import and export. The NIb protein of turnip mosaic virus (TuMV) is an RNA-dependent RNA polymerase (RdRP) that is absolutely ...
Mingzhen Zhang +11 more
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Structural determinants of nuclear export signal orientation in binding to exportin CRM1 [PDF]
eLife, 2015 The Chromosome Region of Maintenance 1 (CRM1) protein mediates nuclear export of hundreds of proteins through recognition of their nuclear export signals (NESs), which are highly variable in sequence and structure.
Ho Yee Joyce Fung +3 more
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Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals
eLife, 2017 Nuclear export receptor CRM1 binds highly variable nuclear export signals (NESs) in hundreds of different cargoes. Previously we have shown that CRM1 binds NESs in both polypeptide orientations (Fung et al., 2015).
Ho Yee Joyce Fung +2 more
doaj +3 more sources
Dual function of the nuclear export signal of the Borna disease virus nucleoprotein in nuclear export activity and binding to viral phosphoprotein [PDF]
Virology Journal, 2017 Background Borna disease virus (BoDV), which has a negative-sense, single-stranded RNA genome, causes persistent infection in the cell nucleus. The nuclear export signal (NES) of the viral nucleoprotein (N) consisting of leucine at positions 128 and 131 ...
Mako Yanai +3 more
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