Nuclear export of L-periaxin, mediated by its nuclear export signal in the PDZ domain. [PDF]
PLoS ONE, 2014 Myelinating Schwann cells specifically express L-periaxin (L-PRX) in the mammalian peripheral nervous system. Several loss-of-function mutations in periaxin have been described and linked to autosomal recessive Dejerine Sottas neuropathy and to ...
Yawei Shi, Lei Zhang, Ting Yang
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NOA1, a novel ClpXP substrate, takes an unexpected nuclear detour prior to mitochondrial import. [PDF]
PLoS ONE, 2014 The mitochondrial matrix GTPase NOA1 is a nuclear encoded protein, essential for mitochondrial protein synthesis, oxidative phosphorylation and ATP production. Here, we demonstrate that newly translated NOA1 protein is imported into the nucleus, where it
Natalie Al-Furoukh +5 more
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The signal sequence coding region promotes nuclear export of mRNA. [PDF]
PLoS Biology, 2007 In eukaryotic cells, most mRNAs are exported from the nucleus by the transcription export (TREX) complex, which is loaded onto mRNAs after their splicing and capping.
Alexander F Palazzo +5 more
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eEF1A Mediates the Nuclear Export of SNAG-Containing Proteins via the Exportin5-Aminoacyl-tRNA Complex [PDF]
Cell Reports, 2013 Exportin5 mediates the nuclear export of double-stranded RNAs, including pre-microRNAs, adenoviral RNAs, and tRNAs. When tRNAs are aminoacylated, the Exportin5-aminoacyl (aa)-tRNA complex recruits and coexports the translation elongation factor eEF1A ...
José Manuel Mingot +4 more
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Protocol for nuclear export signal characterization of cGAS in mammalian cells [PDF]
STAR Protocols, 2021 Summary: The cyclic GMP-AMP synthase (cGAS) is the principal DNA sensor, which binds DNA and triggers the type I interferon production. We used ISD45 or inactivated Vaccinia Virus (VACV) to stimulate cGAS and monitored cellular localization by ...
Yu Huang +3 more
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Nuclear Export Signal Masking Regulates HIV-1 Rev Trafficking and Viral RNA Nuclear Export. [PDF]
J Virol, 2017 ABSTRACT HIV-1's Rev protein forms a homo-oligomeric adaptor complex linking viral RNAs to the cellular CRM1/Ran-GTP nuclear export machinery through the activity of Rev's prototypical leucine-rich nuclear export signal (NES). In this study, we used a functional fluorescently tagged Rev fusion protein as a platform to study the effects of ...
Behrens RT +4 more
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Structural determinants of nuclear export signal orientation in binding to exportin CRM1 [PDF]
eLife, 2015 The Chromosome Region of Maintenance 1 (CRM1) protein mediates nuclear export of hundreds of proteins through recognition of their nuclear export signals (NESs), which are highly variable in sequence and structure.
Ho Yee Joyce Fung +3 more
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Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis. [PDF]
Cancer Discov, 2019 Abstract Altered expression of XPO1, the main nuclear export receptor in eukaryotic cells, has been observed in cancer, and XPO1 has been a focus of anticancer drug development. However, mechanistic evidence for cancer-specific alterations in XPO1 function is lacking. Here, genomic analysis of
Taylor J +26 more
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A TFEB nuclear export signal integrates amino acid supply and glucose availability [PDF]
Nature Communications, 2018 On amino acid deprivation TFEB translocates from the cytoplasm to the nucleus. Here the authors identify a nuclear export signal in TFEB that requires dual phosphorylation at the S142 ERK/mTORC1 and S138 GSK3β sites, and further show glucose limitation ...
Linxin Li +10 more
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Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals
eLife, 2017 Nuclear export receptor CRM1 binds highly variable nuclear export signals (NESs) in hundreds of different cargoes. Previously we have shown that CRM1 binds NESs in both polypeptide orientations (Fung et al., 2015).
Ho Yee Joyce Fung +2 more
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