Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. [PDF]
, 2013 Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the ...
Estes, M. K. +4 more
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NLSdb—major update for database of nuclear localization signals and nuclear export signals [PDF]
Nucleic Acids Research, 2017 NLSdb is a database collecting nuclear export signals (NES) and nuclear localization signals (NLS) along with experimentally annotated nuclear and non-nuclear proteins. NES and NLS are short sequence motifs related to protein transport out of and into the nucleus. The updated NLSdb now contains 2253 NLS and introduces 398 NES.
Michael Bernhofer +6 more
openaire +5 more sources
Analysis of the Activity of Nuclear Export Signals Using Fluorescent BSA Conjugates
BioTechniques, 2002 Here we demonstrate that fluorescein-labeled BSA conjugated with a mixture of nuclear import and export signals can be used to evaluate export activity.
Carl M. Feldherr, Debra Akin
doaj +1 more source
Controlling protein transport by small molecules [PDF]
, 2011 Many proteins are transported from the nucleus to the cytoplasm by the exportin CRM1, which recognizes cargo proteins through a leucine rich nuclear export signal (NES).
Karl Gademann, Gademann, Karl
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NOA1, a novel ClpXP substrate, takes an unexpected nuclear detour prior to mitochondrial import. [PDF]
PLoS ONE, 2014 The mitochondrial matrix GTPase NOA1 is a nuclear encoded protein, essential for mitochondrial protein synthesis, oxidative phosphorylation and ATP production. Here, we demonstrate that newly translated NOA1 protein is imported into the nucleus, where it
Natalie Al-Furoukh +5 more
doaj +1 more source
The nuclear pore complex : its role in chromatin structure and RNA export [PDF]
, 2015 Epigenetic regulation of gene expression is a relatively new and rapidly developing research field. It studies the mechanisms of regulation of gene expression, which although heritable, occur independently of changes in the DNA sequence and certainly aid
Hristova, Emilia
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Identification of essential sequences for cellular localization in BRMS1 metastasis suppressor. [PDF]
PLoS ONE, 2009 BACKGROUND:Breast cancer metastasis suppressor 1 (BRMS1) reduces the number and the size of secondary tumours in a mouse model without affecting the growth of the primary foci upon its re-expression.
José Rivera +3 more
doaj +1 more source
An Endoribonuclease Functionally Linked to Perinuclear mRNP Quality Control Associates with the Nuclear Pore Complexes [PDF]
, 2009 Nuclear mRNA export is a crucial step in eukaryotic gene expression, which is in yeast coupled to cotranscriptional messenger ribonucleoprotein particle ( mRNP) assembly and surveillance.
Attila Rácz +17 more
core +1 more source
CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals [PDF]
Cell, 1997 CRM1 is distantly related to receptors that mediate nuclear protein import and was previously shown to interact with the nuclear pore complex. Overexpression of CRM1 in Xenopus oocytes stimulates Rev and U snRNA export from the nucleus. Conversely, leptomycin B, a cytotoxin that is shown to bind to CRM1 protein, specifically inhibits the nuclear export
Fornerod, Maarten +3 more
openaire +2 more sources
Nuclear Import and Export Signals of Human Cohesins SA1/STAG1 and SA2/STAG2 Expressed in Saccharomyces cerevisiae [PDF]
, 2012 Background: Human SA/STAG proteins, homologues of the yeast Irr1/Scc3 cohesin, are the least studied constituents of the sister chromatid cohesion complex crucial for proper chromosome segregation.
Jurek, Marta +27 more
core +1 more source