Results 41 to 50 of about 3,507,867 (287)
PLoS ONE, 2015 The Ran GTPase activating protein RanGAP1 plays an essential role in nuclear transport by stimulating RanGTP hydrolysis in the cytoplasmic compartment.
Keith Cha +3 more
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Nucleocytoplasmic shuttling of the TACC protein Mia1p/Alp7p is required for remodeling of microtubule arrays during the cell cycle. [PDF]
PLoS ONE, 2009 Microtubule arrays are remodeled as cells proceed through the cell cycle. It is important to understand how remodeling is regulated in time and space.
Yuen Chyao Ling +2 more
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Inhibition of mRNA export in vertebrate cells by nuclear export signal conjugates [PDF]
Proceedings of the National Academy of Sciences, 1997 Leucine-rich nuclear export signals (NESs) are recognized by the NES receptor exportin 1 and are central to the export of multiple shuttling proteins and RNAs. The export of messenger RNA in vertebrates was, however, thought to occur by a different pathway, because inhibition by injection of a synthetic Rev NES conjugate could not be demonstrated. Here
A E, Pasquinelli +4 more
openaire +2 more sources
BMC Molecular and Cell Biology, 2022 Background Swi6 acts as a transcription factor in budding yeast, functioning in two different heterodimeric complexes, SBF and MBF, that activate the expression of distinct but overlapping sets of genes.
Kenneth D. Belanger +8 more
doaj +1 more source
Editorial Note: The Signal Sequence Coding Region Promotes Nuclear Export of mRNA. [PDF]
PLoS BiologyPLOS Biology Editors
doaj +2 more sources
Mediated nuclear import and export of TAZ and the underlying molecular requirements
Nature Communications, 2018 The transcriptional co-factors Yap and TAZ are regulated by Hippo signalling and mechanical forces via their nucleocytoplasmic shuttling. Here the authors identify a RhoA-regulated C-terminal nuclear localization signal and a TEAD-regulated N-terminal ...
Michael Kofler +5 more
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Control of the nuclear localization of Extradenticle by competing nuclear import and export signals [PDF]
Genes & Development, 1999 The Drosophila PBC protein Extradenticle (Exd) is regulated at the level of its subcellular distribution: It is cytoplasmic in the absence of Homothorax (Hth), a Meis family member, and nuclear in the presence of Hth. Here we present evidence that, in the absence of Hth, Exd is exported from nuclei due to the activity of a nuclear export signal (NES ...
M, Abu-Shaar, H D, Ryoo, R S, Mann
openaire +2 more sources
A non-canonical mechanism for Crm1-export cargo complex assembly
eLife, 2015 The transport receptor Crm1 mediates the export of diverse cargos containing leucine-rich nuclear export signals (NESs) through complex formation with RanGTP.
Ute Fischer +6 more
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Analysis and prediction of leucine-rich nuclear export signals [PDF]
Protein Engineering, Design and Selection, 2004 We present a thorough analysis of nuclear export signals and a prediction server, which we have made publicly available. The machine learning prediction method is a significant improvement over the generally used consensus patterns. Nuclear export signals (NESs) are extremely important regulators of the subcellular location of proteins. This regulation
la Cour, Tanja +5 more
openaire +3 more sources
NESmapper: accurate prediction of leucine-rich nuclear export signals using activity-based profiles. [PDF]
PLoS Computational Biology, 2014 The nuclear export of proteins is regulated largely through the exportin/CRM1 pathway, which involves the specific recognition of leucine-rich nuclear export signals (NESs) in the cargo proteins, and modulates nuclear-cytoplasmic protein shuttling by ...
Shunichi Kosugi +3 more
doaj +1 more source