Nucleocytoplasmic shuttling of the TACC protein Mia1p/Alp7p is required for remodeling of microtubule arrays during the cell cycle. [PDF]
PLoS ONE, 2009 Microtubule arrays are remodeled as cells proceed through the cell cycle. It is important to understand how remodeling is regulated in time and space.
Yuen Chyao Ling +2 more
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Inhibition of mRNA export in vertebrate cells by nuclear export signal conjugates [PDF]
Proceedings of the National Academy of Sciences, 1997 Leucine-rich nuclear export signals (NESs) are recognized by the NES receptor exportin 1 and are central to the export of multiple shuttling proteins and RNAs. The export of messenger RNA in vertebrates was, however, thought to occur by a different pathway, because inhibition by injection of a synthetic Rev NES conjugate could not be demonstrated. Here
A E, Pasquinelli +4 more
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BMC Molecular and Cell Biology, 2022 Background Swi6 acts as a transcription factor in budding yeast, functioning in two different heterodimeric complexes, SBF and MBF, that activate the expression of distinct but overlapping sets of genes.
Kenneth D. Belanger +8 more
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RNA export factor Ddx19 is required for nuclear import of the SRF coactivator MKL1 [PDF]
, 2015 Controlled transport of macromolecules between the cytoplasm and nucleus is essential for homeostatic regulation of cellular functions. For instance, gene expression entails coordinated nuclear import of transcriptional regulators to activate ...
Vartiainen, Maria K. +5 more
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Mediated nuclear import and export of TAZ and the underlying molecular requirements
Nature Communications, 2018 The transcriptional co-factors Yap and TAZ are regulated by Hippo signalling and mechanical forces via their nucleocytoplasmic shuttling. Here the authors identify a RhoA-regulated C-terminal nuclear localization signal and a TEAD-regulated N-terminal ...
Michael Kofler +5 more
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Editorial Note: The Signal Sequence Coding Region Promotes Nuclear Export of mRNA [PDF]
PLoS BiologyPLOS Biology Editors.
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Control of the nuclear localization of Extradenticle by competing nuclear import and export signals [PDF]
Genes & Development, 1999 The Drosophila PBC protein Extradenticle (Exd) is regulated at the level of its subcellular distribution: It is cytoplasmic in the absence of Homothorax (Hth), a Meis family member, and nuclear in the presence of Hth. Here we present evidence that, in the absence of Hth, Exd is exported from nuclei due to the activity of a nuclear export signal (NES ...
M, Abu-Shaar, H D, Ryoo, R S, Mann
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tRNAs promote nuclear import of HIV-1 intracellular reverse transcription complexes [PDF]
, 2006 Infection of non-dividing cells is a biological property of HIV-1 crucial for virus transmission and AIDS pathogenesis. This property depends on nuclear import of the intracellular reverse transcription and pre-integration complexes (RTCs/PICs).
Zaitseva Lyubov +8 more
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NESmapper: accurate prediction of leucine-rich nuclear export signals using activity-based profiles. [PDF]
PLoS Computational Biology, 2014 The nuclear export of proteins is regulated largely through the exportin/CRM1 pathway, which involves the specific recognition of leucine-rich nuclear export signals (NESs) in the cargo proteins, and modulates nuclear-cytoplasmic protein shuttling by ...
Shunichi Kosugi +3 more
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Functional characterization of MODY2 mutations in the nuclear export signal of glucokinase [PDF]
, 2018 Glucokinase (GCK) plays a key role in glucose homeostasis. Heterozygous inactivating mutations in the GCK gene cause the familial, mild fasting hyperglycaemia named MODY2.
Olivier Vincent +9 more
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