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CRM1 Inhibitors for Antiviral Therapy [PDF]

Frontiers in Microbiology, 2017
Infectious diseases are a major global concern and despite major advancements in medical research, still cause significant morbidity and mortality. Progress in antiviral therapy is particularly hindered by appearance of mutants capable of overcoming the ...
Reena Ghildyal
exaly   +6 more sources

Small Molecule Inhibitors of CRM1 [PDF]

Frontiers in Pharmacology, 2020
The transport through the nuclear pore complex is used by cancer cells to evade tumor-suppressive mechanisms. Several tumor-suppressors have been shown to be excluded from the cell nucleus in cancer cells by the nuclear export receptor CRM1 and abnormal ...
Bibiana I. Ferreira, Bibiana I. Ferreira, Bibiana I. Ferreira, Bastien Cautain, Bastien Cautain, Inês Grenho, Inês Grenho, Inês Grenho, Wolfgang Link   +8 more
doaj   +8 more sources

Novel—and Not So Novel—Inhibitors of the Multifunctional CRM1 Protein [PDF]

Oncology Reviews
Chromosome Region Maintenance 1 (CRM1), also known as Exportin 1 (XPO1), is a protein that is critical for transport of proteins and RNA to the cytoplasm through the nuclear pore complex.
Waitman K. Aumann, Waitman K. Aumann, Rafi Kazi, Amanda M. Harrington, Daniel S. Wechsler, Daniel S. Wechsler   +5 more
doaj   +3 more sources

Hepatitis B virus virion secretion is a CRM1-spike-mediated late event

Journal of Biomedical Science, 2022
Background Hepatitis B virus (HBV) is a major human pathogen worldwide. To date, there is no curative treatment for chronic hepatitis B. The mechanism of virion secretion remains to be investigated.
Pei-Yi Su, Shin-Chwen Bruce Yen, Ching-Chun Yang, Chih-Hsu Chang, Wen-Chang Lin, Chiaho Shih   +5 more
doaj   +2 more sources

Rescue of Mitochondrial Function in Hutchinson-Gilford Progeria Syndrome by the Pharmacological Modulation of Exportin CRM1

Cells, 2023
Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder caused by the expression of progerin, a mutant variant of Lamin A. Recently, HGPS studies have gained relevance because unraveling its underlying mechanism would help to ...
Feliciano Monterrubio-Ledezma, Fernando Navarro-García, Lourdes Massieu, Ricardo Mondragón-Flores, Luz Adriana Soto-Ponce, Jonathan J. Magaña, Bulmaro Cisneros   +6 more
doaj   +2 more sources

CRM1-spike-mediated nuclear export of hepatitis B virus encapsidated viral RNA

Cell Reports, 2022
Summary: Hepatitis B virus (HBV) is a global pathogen. We report here that the cellular CRM1 machinery can mediate nuclear export of entire HBV core (HBc) particles containing encapsidated viral RNAs.
Ching-Chun Yang, Chih-Hsu Chang, Heng-Li Chen, Ming-Chieh Chou, Ching-Jen Yang, Ren-Shiang Jhou, Er-Yi Huang, Hung-Cheng Li, Ching-Shu Suen, Ming-Jing Hwang, Chiaho Shih   +10 more
doaj   +2 more sources

Crm1-Dependent Nuclear Export of Bach1 is Involved in the Protective Effect of Hyperoside on Oxidative Damage in Hepatocytes and CCl4-induced Acute Liver Injury

Journal of Inflammation Research, 2021
Yongqing Cai1 *,* Bin Li1 *,* Dan Peng,1 Xianfeng Wang,1 Pan Li,2 Mingchun Huang,3 Haiyan Xing,1 Jianhong Chen1 1Department of Pharmacy, Daping Hospital, Army Medical University, Chongqing, 400042, People’s Republic of China; 2Department of ...
Cai Y, Li B, Peng D, Wang X, Li P, Huang M, Xing H, Chen J   +7 more
doaj   +2 more sources

Nuclear export of BATF2 enhances colorectal cancer proliferation through binding to CRM1

Clinical and Translational Medicine, 2023
Background During the tumourigenesis and development of colorectal cancer (CRC), the inactivation of tumour suppressor genes is closely involved, although detailed molecular mechanisms remain elusive.
Jie Zhou, Zengjie Lei, Jianfang Chen, Shengbo Liao, Yanrong Chen, Chengxiang Liu, Shuo Huang, Liuli Li, Yan Zhang, Pei Wang, Yinghui Huang, Jianjun Li, Houjie Liang   +12 more
doaj   +2 more sources

Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers

Nature Communications, 2021
Survivin’s dual function as apoptosis inhibitor and regulator of cell proliferation is mediated via its interaction with the export receptor CRM1. Here authors report a strategy addressing its dimer interface overlapping with the nuclear export signal ...
Annika Meiners, Sandra Bäcker, Inesa Hadrović, Christian Heid, Christine Beuck, Yasser B. Ruiz-Blanco, Joel Mieres-Perez, Marius Pörschke, Jean-Noël Grad, Cecilia Vallet, Daniel Hoffmann, Peter Bayer, Elsa Sánchez-García, Thomas Schrader, Shirley K. Knauer   +14 more
doaj   +2 more sources

Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure

Cell Reports, 2023
Summary: NUP98 and NUP214 form chimeric fusion proteins that assemble into phase-separated nuclear bodies containing CRM1, a nuclear export receptor. However, these nuclear bodies’ function in controlling gene expression remains elusive.
Masahiro Oka, Mayumi Otani, Yoichi Miyamoto, Rieko Oshima, Jun Adachi, Takeshi Tomonaga, Munehiro Asally, Yuya Nagaoka, Kaori Tanaka, Atsushi Toyoda, Kazuki Ichikawa, Shinichi Morishita, Kyoichi Isono, Haruhiko Koseki, Ryuichiro Nakato, Yasuyuki Ohkawa, Yoshihiro Yoneda   +16 more
doaj   +2 more sources