Results 1 to 10 of about 9,261 (202)

Chromenone Derivatives as CRM1 Inhibitors for Targeting Glioblastoma. [PDF]

Chembiochem
Glioblastoma (GBM) is one of the most aggressive and deadly cancers. Due to the complexity and redundancy within signaling networks in GBM, targeted inhibitors of specific pathways have shown only limited success. The nuclear export receptor chromosome region maintenance 1 (CRM1) has recently emerged as a promising therapeutic target, as its inhibition
Princiotto S, Jiménez L, Domínguez L, Sequeira JGN, Mourato C, Orea-Soufi A, Santos B, Dallavalle S, Machuqueiro M, Ferreira BI, Link W.   +10 more
europepmc   +5 more sources

Structural basis for the synergistic assembly of the snRNA export complex. [PDF]

Nat Struct Mol Biol
Dubiez E, Garland W, Finderup Brask M, Boeri Erba E, Heick Jensen T, Kadlec J, Cusack S.   +6 more
europepmc   +1 more source

MPL receptor dimerization and the thrombopoietin pathway in primary immune thrombocytopenia: from molecular mechanisms to targeted therapies. [PDF]

Front Med (Lausanne)
Wang Y, Liu C, Hu Y, Sun X, Zhang W, Zhu W.   +5 more
europepmc   +1 more source

FSH-Induced Nuclear Exclusion of FOXO1 Mediated by PI3K/Akt Signaling Pathway in Granulosa Cells Is Associated with Follicle Selection and Growth of the Hen Ovary. [PDF]

Cells
Yan C, Ou Y, Sun X, Sun Y, Zhao J, Qin N, Xu R.   +6 more
europepmc   +1 more source

Neuroinflammation and NeuroHIV: understanding the role of HIV-1 related factors in microglial activation. [PDF]

Transl Psychiatry
Zhao J, Bu F, Wu H, He J, Liu J.
europepmc   +1 more source

FASN for diffuse malignant peritoneal mesothelioma: a prognostic biomarker after CRS+HIPEC and a therapeutic target. [PDF]

J Transl Med
Doldi V, Ciniselli CM, Aurelio C, Favini E, Veronese SM, Bozzi F, Kusamura S, Baratti D, Martini S, Verderio P, Deraco M, Folini M, Gandellini P, Pasquali S, Zaffaroni N.   +14 more
europepmc   +1 more source

Spatiotemporal regulation of MKK4 dictates switch-like JNK activation and binary cell-fate decisions. [PDF]

Nat Commun
Moriizumi H, Nakamura T, Kubota Y, Hiranuma R, Cho Y, Kawanishi T, Takeda H, Suzuki T, Takekawa M.   +8 more
europepmc   +1 more source

A Structural View of Influenza Virus Ribonucleoprotein Complex and Its Functions. [PDF]

Microorganisms
Liu Y, Zhang L, Lin Y, Lou Z.
europepmc   +1 more source

Nutriepigenetics in Skin Homeostasis: Molecular Mechanisms of Honey-Mediated Chromatin Remodeling in Non-Healing Ulcers. [PDF]

Biomolecules
Ranzato E, Martinotti S.
europepmc   +1 more source

Mislocalization of FTD3-associated mutant CHMP2B to the nucleus of human neurons due to loss of a nuclear export signal. [PDF]

Acta Neuropathol Commun
Jun YW, Hass EP, Lee S, Fazzio TG, Gao FB.   +4 more
europepmc   +1 more source