Results 31 to 40 of about 9,261 (202)

The HIV-1 nuclear export complex reveals the role of RNA in CRM1 cargo recognition [PDF]

Molecular Cell
Yifan Cheng, Alan D Frankel, Amber M Smith   +2 more
exaly   +2 more sources

The nuclear export receptor CRM1/XPO1 and its diverse cargoes [PDF]

Trends in Biochemical Sciences
Yuh Min Chook, Ralph H Kehlenbach
exaly   +2 more sources

Viral Subversion of the Chromosome Region Maintenance 1 Export Pathway and Its Consequences for the Cell Host

Viruses, 2023
In eukaryotic cells, the spatial distribution between cytoplasm and nucleus is essential for cell homeostasis. This dynamic distribution is selectively regulated by the nuclear pore complex (NPC), which allows the passive or energy-dependent transport of
Makram Mghezzi-Habellah, Léa Prochasson, Pierre Jalinot, Vincent Mocquet   +3 more
doaj   +1 more source

Hepatitis B virus virion secretion is a CRM1-spike-mediated late event

Journal of Biomedical Science, 2022
Background Hepatitis B virus (HBV) is a major human pathogen worldwide. To date, there is no curative treatment for chronic hepatitis B. The mechanism of virion secretion remains to be investigated.
Pei-Yi Su, Shin-Chwen Bruce Yen, Ching-Chun Yang, Chih-Hsu Chang, Wen-Chang Lin, Chiaho Shih   +5 more
doaj   +1 more source

Investigation of Reversible Covalent Inhibitors of CRM1 [PDF]

, 2023
The Chromosome Region of Maintenance 1 or CRM1 protein is the master regulator that handles the export of hundreds of proteins and RNA molecules from eukaryotic cell nuclei.
Vo, Duy Anh
core   +1 more source

A non-canonical mechanism for Crm1-export cargo complex assembly

eLife, 2015
The transport receptor Crm1 mediates the export of diverse cargos containing leucine-rich nuclear export signals (NESs) through complex formation with RanGTP.
Ute Fischer, Nico Schäuble, Sabina Schütz, Martin Altvater, Yiming Chang, Marius Boulos Faza, Vikram Govind Panse   +6 more
doaj   +1 more source

Controlling protein transport by small molecules [PDF]

, 2011
Many proteins are transported from the nucleus to the cytoplasm by the exportin CRM1, which recognizes cargo proteins through a leucine rich nuclear export signal (NES).
Karl Gademann, Gademann, Karl
core   +1 more source

Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity

Cells, 2019
DEAD-box helicase 3, X-linked (DDX3X) regulates the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR)-mediated antiviral response, but can also be a host factor contributing to the replication of viruses of significance to human health, such as ...
Steven M. Heaton, Sarah C. Atkinson, Melissa N. Sweeney, Sundy N. Y. Yang, David A. Jans, Natalie A. Borg   +5 more
doaj   +1 more source

Rescue of Mitochondrial Function in Hutchinson-Gilford Progeria Syndrome by the Pharmacological Modulation of Exportin CRM1

Cells, 2023
Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder caused by the expression of progerin, a mutant variant of Lamin A. Recently, HGPS studies have gained relevance because unraveling its underlying mechanism would help to ...
Feliciano Monterrubio-Ledezma, Fernando Navarro-García, Lourdes Massieu, Ricardo Mondragón-Flores, Luz Adriana Soto-Ponce, Jonathan J. Magaña, Bulmaro Cisneros   +6 more
doaj   +1 more source

Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export

Cell Reports, 2015
CRM1 is the major nuclear export receptor. During translocation through the nuclear pore, transport complexes transiently interact with phenylalanine-glycine (FG) repeats of multiple nucleoporins. On the cytoplasmic side of the nuclear pore, CRM1 tightly
Sarah A. Port, Thomas Monecke, Achim Dickmanns, Christiane Spillner, Romina Hofele, Henning Urlaub, Ralf Ficner, Ralph H. Kehlenbach   +7 more
doaj   +1 more source