Results 31 to 40 of about 7,200 (169)

Crm1-Dependent Nuclear Export of Bach1 is Involved in the Protective Effect of Hyperoside on Oxidative Damage in Hepatocytes and CCl4-induced Acute Liver Injury

Journal of Inflammation Research, 2021
Yongqing Cai1 *,* Bin Li1 *,* Dan Peng,1 Xianfeng Wang,1 Pan Li,2 Mingchun Huang,3 Haiyan Xing,1 Jianhong Chen1 1Department of Pharmacy, Daping Hospital, Army Medical University, Chongqing, 400042, People’s Republic of China; 2Department of ...
Cai Y, Li B, Peng D, Wang X, Li P, Huang M, Xing H, Chen J   +7 more
doaj  

The SQSTM1-NUP214 fusion protein interacts with Crm1, activates Hoxa and Meis1 genes, and drives leukemogenesis in mice.

PLoS ONE, 2020
The NUP98 and NUP214 nucleoporins (NUPs) are recurrently fused to heterologous proteins in leukemia. The resulting chimeric oncoproteins retain the phenylalanine-glycine (FG) repeat motifs of the NUP moiety that mediate interaction with the nuclear ...
Catherine P Lavau, Waitman K Aumann, Sei-Gyung K Sze, Veerain Gupta, Katelyn Ripple, Sarah A Port, Ralph H Kehlenbach, Daniel S Wechsler   +7 more
doaj   +1 more source

Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers

Nature Communications, 2021
Survivin’s dual function as apoptosis inhibitor and regulator of cell proliferation is mediated via its interaction with the export receptor CRM1. Here authors report a strategy addressing its dimer interface overlapping with the nuclear export signal ...
Annika Meiners, Sandra Bäcker, Inesa Hadrović, Christian Heid, Christine Beuck, Yasser B. Ruiz-Blanco, Joel Mieres-Perez, Marius Pörschke, Jean-Noël Grad, Cecilia Vallet, Daniel Hoffmann, Peter Bayer, Elsa Sánchez-García, Thomas Schrader, Shirley K. Knauer   +14 more
doaj   +1 more source

CRM1 and Ran are present but a NES-CRM1-RanGTP complex is not required in Balbiani ring mRNP particles from the gene to the cytoplasm [PDF]

Journal of Cell Science, 2004
Messenger RNA is formed from precursors known as pre-mRNA. These precursors associate with proteins to form pre-mRNA-protein (pre-mRNP) complexes. Processing machines cap, splice and polyadenylate the pre-mRNP and in this way build the mRNP. These processing machines also affect the export of the mRNP complexes from the nucleus to the cytoplasm. Export
Jian, Zhao, Shao-Bo, Jin, Lars, Wieslander   +2 more
openaire   +2 more sources

Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor

International Journal of Nanomedicine, 2021
Min Sui,1,* Meimei Xiong,2,* Yuling Li,1,* Qiao Zhou,1 Xiaofei Shen,3 Da Jia,3 Maling Gou,2 Qingxiang Sun1 1Department of Pathology and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Centre for ...
Sui M, Xiong M, Li Y, Zhou Q, Shen X, Jia D, Gou M, Sun Q   +7 more
doaj  

E2F4 Is Exported from the Nucleus in a CRM1-Dependent Manner [PDF]

Molecular and Cellular Biology, 2001
E2F is a family of transcription factors required for normal cell cycle control and for cell cycle arrest in G1. E2F4 is the most abundant E2F protein in many cell types. In quiescent cells, it is localized to the nucleus, where it is bound to the retinoblastoma-related protein p130.
S, Gaubatz, J A, Lees, G J, Lindeman, D M, Livingston   +3 more
openaire   +2 more sources

Back-spliced RNA from retrotransposon binds to centromere and regulates centromeric chromatin loops in maize.

PLoS Biology, 2020
In most plants, centromeric DNA contains highly repetitive sequences, including tandem repeats and retrotransposons; however, the roles of these sequences in the structure and function of the centromere are unclear.
Yalin Liu, Handong Su, Jing Zhang, Yang Liu, Chao Feng, Fangpu Han   +5 more
doaj   +1 more source

The karyopherin CRM1 is required for dendritic cell maturation

Immunobiology, 2010
Dendritic cells (DC) are the most potent antigen-presenting cells (APC) of the immune system and are specialized to activate T as well as B cell-dependent immune responses. Mature DC are characterized by expression of CD83, a surface molecule that has been postulated to be required for efficient DC activity.
Jan, Chemnitz, Nadine, Turza, Ilona, Hauber, Alexander, Steinkasserer, Joachim, Hauber   +4 more
openaire   +2 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Atomic basis of CRM1-cargo recognition, release and inhibition [PDF]

Seminars in Cancer Biology, 2014
CRM1 or XPO1 is the major nuclear export receptor in the cell, which controls the nuclear-cytoplasmic localization of many proteins and RNAs. CRM1 is also a promising cancer drug target as the transport receptor is overexpressed in many cancers where some of its cargos are misregulated and mislocalized to the cytoplasm.
Ho Yee Joyce, Fung, Yuh Min, Chook
openaire   +2 more sources