Results 31 to 40 of about 18,104 (240)

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer. [PDF]

Adv Sci (Weinh)
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Lv C, Lin Z, Sun J, Ye Y, Wu Q, Cai L, Liu D, Sun P, Wang S.   +8 more
europepmc   +2 more sources

Targeting CRM1 for Progeria Syndrome Therapy. [PDF]

Aging Cell
ABSTRACTHutchinson‐Gilford progeria syndrome (HGPS) is a premature aging disease caused by progerin, a mutant variant of lamin A. Progerin anchors aberrantly to the nuclear envelope disrupting a plethora of cellular processes, which in turn elicits senescence.
Soto-Ponce A, De Ita M, Castro-Obregón S, Cortez D, Landesman Y, Magaña JJ, Gonzalo S, Zavaleta T, Soberano-Nieto A, Unzueta J, Arrieta-Cruz I, Nava P, Candelario-Martínez A, García-Aguirre I, Cisneros B.   +14 more
europepmc   +3 more sources

Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain

Oxidative Medicine and Cellular Longevity, 2021
Brain aging is characterized by dysfunctional autophagy and cellular senescence, among other features. While autophagy can either promote or suppress cellular senescence in proliferating cells, in postmitotic cells, such as neurons, autophagy impairment ...
E. Gorostieta-Salas, Daniel Moreno-Blas, C. Gerónimo-Olvera, B. Cisneros, F. Court, S. Castro-Obregón   +5 more
semanticscholar   +1 more source

Exportin Crm1 is important for Swi6 nuclear shuttling and MBF transcription activation in Saccharomyces cerevisiae

BMC Molecular and Cell Biology, 2022
Background Swi6 acts as a transcription factor in budding yeast, functioning in two different heterodimeric complexes, SBF and MBF, that activate the expression of distinct but overlapping sets of genes.
Kenneth D. Belanger, William T. Yewdell, Matthew F. Barber, Amy N. Russo, Mark A. Pettit, Emily K. Damuth, Naveen Hussain, Susan J. Geier, Karyn G. Belanger   +8 more
doaj   +1 more source

Multiplexed cellular profiling identifies an organoselenium compound as an inhibitor of CRM1‐mediated nuclear export

Traffic : the International Journal of Intracellular Transport, 2022
Chromosomal region maintenance 1 (CRM1 also known as Xpo1 and exportin‐1) is the receptor for the nuclear export controlling the intracellular localization and function of many cellular and viral proteins that play a crucial role in viral infections and ...
Lucía Jiménez, Víctor Mayoral-Varo, Carlos Amenabar, Judit Ortega, João G N Sequeira, M. Machuqueiro, Cristiana Mourato, R. Silvestri, A. Angeli, F. Carta, C. Supuran, D. Megías, Bibiana I. Ferreira, W. Link   +13 more
semanticscholar   +1 more source

Structural Determinants and Mechanism of Mammalian CRM1 Allostery [PDF]

Structure, 2013
Published by Elsevier Science, London [u.a.]
Dölker, Nicole, BLANCHET, Clement, Voß, Béla, Haselbach, David, Kappel, Christian, Monecke, Thomas, Svergun, Dmitri, Stark, Holger, Ficner, Ralf, Zachariae, Ulrich, Grubmüller, Helmut, Dickmanns, Achim   +11 more
openaire   +6 more sources

Nuclear DDX3 expression predicts poor outcome in colorectal and breast cancer [PDF]

, 2017
Purpose: DEAD box protein 3 (DDX3) is an RNA helicase with oncogenic properties that shuttles between the cytoplasm and nucleus. The majority of DDX3 is found in the cytoplasm, but a subset of tumors has distinct nuclear DDX3 localization of yet unknown ...
Bol, Guus M., Buerger, Horst, Heerman van Voss, Marise R., Meeldijk, Jan, Offerhaus, G. Johan, Patel, Arvind H., Raman, Ana, Raman, Venu, van der Wall, Elsken, van Diest, Paul J., Vesuna, Farhad   +10 more
core   +2 more sources

Nucleocytoplasmic Shuttling of Porcine Parvovirus NS1 Protein Mediated by the CRM1 Nuclear Export Pathway and the Importin α/β Nuclear Import Pathway

Journal of Virology, 2021
PPV replicates in the nucleus, and the nuclear envelope is a barrier to its entry into and egress from the nucleus. PPV NS1 is a nucleus-targeting protein that is important for viral DNA replication.
Liyan Cao, F. Fu, Jianfei Chen, Hongyan Shi, Xin Zhang, Jianbo Liu, D. Shi, Yong Huang, D. Tong, Li Feng   +9 more
semanticscholar   +1 more source

Importin-beta and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function [PDF]

, 2017
Protein conjugation with small ubiquitin-related modifier (SUMO) is a post-translational modification that modulates protein interactions and localisation.
Damizia, Michela, DE SANTIS, RICCARDO, DE TURRIS, VALERIA, GILISTRO, EUGENIA, Lavia, Patrizia, MORONI, SARA, ROSA, ALESSANDRO, VERRICO, ANNALISA   +7 more
core   +1 more source

Selinexor decreases HIF-1α via inhibition of CRM1 in human osteosarcoma and hepatoma cells associated with an increased radiosensitivity

Journal of Cancer Research and Clinical Oncology, 2021
The nuclear pore complexes (NPCs) are built of about 30 different nucleoporins and act as key regulators of molecular traffic between the cytoplasm and the nucleus for sizeable proteins (> 40 kDa) which must enter the nucleus.
Moritz von Fallois, F. K. Kosyna, M. Mandl, Y. Landesman, J. Dunst, R. Depping   +5 more
semanticscholar   +1 more source