Results 21 to 30 of about 9,261 (202)

Involvement of a tick-borne orthomyxovirus matrix protein in vRNP nuclear export [PDF]

Journal of Virology
Thogotoviruses are arthropod-borne viruses belonging to the genus Thogotovirus within the family Orthomyxoviridae. Like other orthomyxoviruses, such as the influenza A viruses (IAV), thogotoviruses replicate in the nucleus.
Vaille A. Swenson, Jack Hemsath, Iris Yousaf, Carla Weisend, Michael A. Barry, Hideki Ebihara, Satoko Yamaoka   +6 more
doaj   +2 more sources

RANBP3 and RAN orchestrate CRM1-mediated nuclear export of hepatitis B virus RNAs [PDF]

Journal of Virology
Nuclear export of viral RNAs is essential for the replication of hepatitis B virus (HBV). Our previous study demonstrated that ELAVL1 (embryonic lethal, abnormal vision, Drosophila-like 1) mediates the nuclear export of HBV RNAs via the chromosome region
Mengfei Wang, Quan Chen, Yingcheng Zheng, Jiatong Yin, Guoguo Zhu, Kaitao Zhao, Zaichao Xu, Rong Hua, Meng Zhou, Lu Zhang, Gaihong Zhao, Shipeng Yang, Zulihuma Amat, Yuchen Xia, Xiaoming Cheng   +14 more
doaj   +2 more sources

Structural basis for cooperativity of CRM1 export complex formation [PDF]

Proceedings of the National Academy of Sciences, 2013
In eukaryotes, the nucleocytoplasmic transport of macromolecules is mainly mediated by soluble nuclear transport receptors of the karyopherin-ß superfamily termed importins and exportins.
Grubmüller, Helmut, Voss, B., Neumann, P., Haselbach, D., Zachariae, U., Monecke, T., Monecke, Thomas, Zachariae, Ulrich; id_orcid, Zachariae, Ulrich, Ficner, R., Russek, A., Voß, D., Russek, Andreas, Hurt, E., Grubmul̈ler, H., Haselbach, David, Stark, H., Voss, Bela, Grubmueller, H., Stark, Holger, Thomson, Emma, Hurt, Ed, Ficner, Ralf, Neumann, Piotr, Thomson, E., Grubmüler, H., Dickmanns, Achim, Dickmanns, A.   +27 more
core   +8 more sources

Exportin Crm1 is important for Swi6 nuclear shuttling and MBF transcription activation in Saccharomyces cerevisiae

BMC Molecular and Cell Biology, 2022
Background Swi6 acts as a transcription factor in budding yeast, functioning in two different heterodimeric complexes, SBF and MBF, that activate the expression of distinct but overlapping sets of genes.
Kenneth D. Belanger, William T. Yewdell, Matthew F. Barber, Amy N. Russo, Mark A. Pettit, Emily K. Damuth, Naveen Hussain, Susan J. Geier, Karyn G. Belanger   +8 more
doaj   +2 more sources

BMI-1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma. [PDF]

FEBS Open Bio
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Umaru B, Mishra DK, Kumar SS, Pang HH, Devine B, Khan K, Drissi R.   +6 more
europepmc   +2 more sources

CRM1 Is a Direct Cellular Target of the Natural Anti-cancer Agent Plumbagin

Journal of Pharmacological Sciences, 2014
Plumbagin, a naphthoquinone derived from the medicinal plant Plumbago zeylanica, has been shown to exert anti-cancer and anti-proliferative activities in vitro as well as in animal tumor models.
Xuejiao Liu, Mingshan Niu, Xiaoyu Xu, Wei Cai, Lingyu Zeng, Xiuping Zhou, Rutong Yu, Kailin Xu   +7 more
doaj   +2 more sources

Structural basis for a nucleoporin exportin complex between RanBP2, SUMO1-RanGAP1, the E2 Ubc9, Crm1 and the Ran GTPase [PDF]

Nature Communications
The human nucleoporin RanBP2/Nup358 interacts with SUMO1-modified RanGAP1 and the SUMO E2 Ubc9 at the nuclear pore complex (NPC) to promote export and disassembly of exportin Crm1/Ran(GTP)/cargo complexes.
Vladimir Baytshtok, Michael A. DiMattia, Christopher D. Lima   +2 more
doaj   +2 more sources

CRM1-mediated nuclear export: to the pore and beyond

Trends in Cell Biology, 2007
CRM1 (chromosome region maintenance 1; also referred to as exportin1 or Xpo1) is a member of the importin beta superfamily of nuclear transport receptors, recognizing proteins bearing a leucine-rich nuclear export sequence. CRM1 is the major receptor for
Hutten, Saskia, Kehlenbach, Ralph H.
core   +3 more sources

Progerin Hinders Autophagy Flux at Its Final Stages in Hutchinson-Gilford Progeria Syndrome Cells, Preventing Its Own Autophagic Degradation. [PDF]

Aging Cell
We demonstrated that progerin induces the formation of autophagosomes but impairs their maturation and subsequent fusion with lysosomes. Progerin impedes proper autophagy flux, thus preventing its own autophagic degradation. Selinexor treatment improved both autophagosome maturation and autophagosome‐lysosome fusion, which ultimately led to effective ...
García-Aguirre I, Reyes-Martínez JA, Unzueta J, Guevara-Namorado F, Lizcano-Meneses S, Gonzalo S, Baldan A, Rangel C, Alanis-Funes GJ, Garcia-Sierra F, Ruiz-Fajardo K, Gormes-Pinchanski S, Castro-Obregón S, Meza-Dorantes A, Chavez-Santoscoy RA, Arrieta-Cruz I, Tristán-Aburto P, Magaña JJ, Cisneros B.   +18 more
europepmc   +2 more sources

Potential effects of CRM1 inhibition in mantle cell lymphoma [PDF]

Chinese Journal of Cancer Research, 2012
Fujian Provincial Department of Science Technology [2009-CXB-57/ 2011J01252]; Bureau of Science & Technology of Xiamen, China [3502Z20094012]Mantle cell lymphoma (MCL) is an aggressive histotype of B-cell non-Hodgkin lymphoma.
Wang, Michael, Zhang, Ke-Jie, 张可杰
core   +4 more sources