Results 21 to 30 of about 18,104 (240)

Enhanced nuclear protein export in premature aging and rescue of the progeria phenotype by modulation of CRM1 activity

Aging Cell, 2019
The study of Hutchinson–Gilford progeria syndrome (HGPS) has provided important clues to decipher mechanisms underlying aging. Progerin, a mutant lamin A, disrupts nuclear envelope structure/function, with further impairment of multiple processes that ...
Griselda Vélez-Aguilera, Alejandra Vasquez-Limeta, Jonathan J Magaña   +2 more
exaly   +2 more sources

CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals

Cell, 1997
Maarten Fornerod, Minoru Yoshida
exaly   +2 more sources

Targeting Nuclear Exporter Protein XPO1/CRM1 in Gastric Cancer [PDF]

International Journal of Molecular Sciences, 2019
Gastric cancer remains an unmet clinical problem in urgent need of newer and effective treatments. Here we show that the nuclear export protein, Exportin 1 (XPO1, chromosome region maintenance 1 or CRM1), is a promising molecular target in gastric cancer.
R. Sexton, Zaid Mahdi, R. Chaudhury, R. Beydoun, A. Aboukameel, H. Khan, E. Baloglu, W. Senapedis, Y. Landesman, Anteneh A. Tesfaye, Steve H Kim, P. Philip, A. Azmi   +12 more
semanticscholar   +3 more sources

PICALM::MLLT10 translocated leukemia. [PDF]

FEBS Lett
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
Cullen JM, Nakatsugawa AC, Barton N, Haines H, Stein GS, Stein JL, Wechsler DS, Heath JL.   +7 more
europepmc   +2 more sources

Correlation of CRM1-NES affinity with nuclear export activity

Molecular Biology of the Cell, 2018
CRM1 (Exportin1/XPO1) exports hundreds of broadly functioning protein cargoes out of the cell nucleus by binding to their classical nuclear export signals (NESs).
Szu-Chin Fu, H. Fung, T. Cagatay, J. Baumhardt, Y. Chook   +4 more
semanticscholar   +3 more sources

Chromenone Derivatives as CRM1 Inhibitors for Targeting Glioblastoma. [PDF]

Chembiochem
Glioblastoma (GBM) is one of the most aggressive and deadly cancers. Due to the complexity and redundancy within signaling networks in GBM, targeted inhibitors of specific pathways have shown only limited success. The nuclear export receptor chromosome region maintenance 1 (CRM1) has recently emerged as a promising therapeutic target, as its inhibition
Princiotto S, Jiménez L, Domínguez L, Sequeira JGN, Mourato C, Orea-Soufi A, Santos B, Dallavalle S, Machuqueiro M, Ferreira BI, Link W.   +10 more
europepmc   +3 more sources

The HIV-1 nuclear export complex reveals the role of RNA in CRM1 cargo recognition [PDF]

Molecular Cell
Smith AM, Li Y, Velarde A, Cheng Y, Frankel AD.   +4 more
exaly   +2 more sources

Fission yeast 26S proteasome mutants are multi-drug resistant due to stabilization of the pap1 transcription factor [PDF]

, 2012
Here we report the result of a genetic screen for mutants resistant to the microtubule poison methyl benzimidazol-2-yl carbamate (MBC) that were also temperature sensitive for growth.
A Varshavsky, C Gordon, Caroline R. Wilkinson, Christopher J. McInerny, Colin Gordon, CR Wilkinson, Deanna M. Koepp, E Strickland, H Seino, IS Nielsen, Itaru Samejima, K Nagao, M Arioka, M Penney, M Shimanuki, Mairi Wallace, Mary Penney, MH Glickman, R Booher, Rasmus Hartmann-Petersen, RJ Dohmen, S Moreno, Søs G. Mathiassen, T Toda, T Toda, Takashi Toda, TG Turi, V Bailly, WM Toone   +28 more
core   +13 more sources

4-Octyl itaconate reduces influenza A replication by targeting the nuclear export protein CRM1

Journal of Virology, 2023
In recent years, especially since the outbreak of the severe acute respiratory syndrome coronavirus 2 pandemic, the cell-permeable itaconate derivative 4-octyl itaconate (4-OI) has gained traction as a potential antiviral agent. Here, we demonstrate that
Pau Ribó-Molina, Hauke J. Weiss, Balasubramanian Susma, S. van Nieuwkoop, L. Persoons, Yunan Zheng, Melanie Ruzek, Dirk Daelemans, R. Fouchier, L. O'Neill, B. G. van den Hoogen   +10 more
semanticscholar   +1 more source

Viral Subversion of the Chromosome Region Maintenance 1 Export Pathway and Its Consequences for the Cell Host

Viruses, 2023
In eukaryotic cells, the spatial distribution between cytoplasm and nucleus is essential for cell homeostasis. This dynamic distribution is selectively regulated by the nuclear pore complex (NPC), which allows the passive or energy-dependent transport of
Makram Mghezzi-Habellah, Léa Prochasson, Pierre Jalinot, Vincent Mocquet   +3 more
doaj   +1 more source