Results 41 to 50 of about 9,261 (202)

CRM1-spike-mediated nuclear export of hepatitis B virus encapsidated viral RNA

Cell Reports, 2022
Summary: Hepatitis B virus (HBV) is a global pathogen. We report here that the cellular CRM1 machinery can mediate nuclear export of entire HBV core (HBc) particles containing encapsidated viral RNAs.
Ching-Chun Yang, Chih-Hsu Chang, Heng-Li Chen, Ming-Chieh Chou, Ching-Jen Yang, Ren-Shiang Jhou, Er-Yi Huang, Hung-Cheng Li, Ching-Shu Suen, Ming-Jing Hwang, Chiaho Shih   +10 more
doaj   +1 more source

The export receptor Crm1 forms a dimer to promote nuclear export of HIV RNA

eLife, 2014
The HIV Rev protein routes viral RNAs containing the Rev Response Element (RRE) through the Crm1 nuclear export pathway to the cytoplasm where viral proteins are expressed and genomic RNA is delivered to assembling virions.
David S Booth, Yifan Cheng, Alan D Frankel   +2 more
doaj   +1 more source

CRM1- and Ran-independent nuclear export of β-catenin [PDF]

Current Biology, 2001
Activation of the Wnt pathway induces beta-catenin to localize inside the nucleus, where it interacts with transcription factors such as TCF/LEF-1. Regulation of the pathway occurs through a beta-catenin-degrading complex based on Axin and the tumor suppressor APC. We have previously found that beta-catenin import occurs independently of nuclear import
Wiechens, N., Fagotto, F. ; https://orcid.org/0000-0002-1495-2112   +1 more
openaire   +3 more sources

Structural determinants of nuclear export signal orientation in binding to exportin CRM1

eLife, 2015
The Chromosome Region of Maintenance 1 (CRM1) protein mediates nuclear export of hundreds of proteins through recognition of their nuclear export signals (NESs), which are highly variable in sequence and structure.
Ho Yee Joyce Fung, Szu-Chin Fu, Chad A Brautigam, Yuh Min Chook   +3 more
doaj   +1 more source

Crm1-Dependent Nuclear Export of Bach1 is Involved in the Protective Effect of Hyperoside on Oxidative Damage in Hepatocytes and CCl4-induced Acute Liver Injury

Journal of Inflammation Research, 2021
Yongqing Cai1 *,* Bin Li1 *,* Dan Peng,1 Xianfeng Wang,1 Pan Li,2 Mingchun Huang,3 Haiyan Xing,1 Jianhong Chen1 1Department of Pharmacy, Daping Hospital, Army Medical University, Chongqing, 400042, People’s Republic of China; 2Department of ...
Cai Y, Li B, Peng D, Wang X, Li P, Huang M, Xing H, Chen J   +7 more
doaj  

Chromatin-bound CRM1 recruits SET-Nup214 and NPM1c onto HOX clusters causing aberrant HOX expression in leukemia cells

eLife, 2019
We previously demonstrated that CRM1, a major nuclear export factor, accumulates at Hox cluster regions to recruit nucleoporin-fusion protein Nup98HoxA9, resulting in robust activation of Hox genes (Oka et al., 2016).
Masahiro Oka, Sonoko Mura, Mayumi Otani, Yoichi Miyamoto, Jumpei Nogami, Kazumitsu Maehara, Akihito Harada, Taro Tachibana, Yoshihiro Yoneda, Yasuyuki Ohkawa   +9 more
doaj   +1 more source

Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor

International Journal of Nanomedicine, 2021
Min Sui,1,* Meimei Xiong,2,* Yuling Li,1,* Qiao Zhou,1 Xiaofei Shen,3 Da Jia,3 Maling Gou,2 Qingxiang Sun1 1Department of Pathology and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Centre for ...
Sui M, Xiong M, Li Y, Zhou Q, Shen X, Jia D, Gou M, Sun Q   +7 more
doaj  

Exportins can inhibit major mitotic assembly events in vitro: membrane fusion, nuclear pore formation, and spindle assembly

Nucleus, 2020
Xenopus egg extracts are a powerful in vitro tool for studying complex biological processes, including nuclear reconstitution, nuclear membrane and pore assembly, and spindle assembly.
Matthew S. Nord, Cyril Bernis, Sarah Carmona, Dennis C. Garland, Anna Travesa, Douglass J. Forbes   +5 more
doaj   +1 more source

CRM1 and Ran are present but a NES-CRM1-RanGTP complex is not required in Balbiani ring mRNP particles from the gene to the cytoplasm [PDF]

Journal of Cell Science, 2004
Messenger RNA is formed from precursors known as pre-mRNA. These precursors associate with proteins to form pre-mRNA-protein (pre-mRNP) complexes. Processing machines cap, splice and polyadenylate the pre-mRNP and in this way build the mRNP. These processing machines also affect the export of the mRNP complexes from the nucleus to the cytoplasm. Export
Jian, Zhao, Shao-Bo, Jin, Lars, Wieslander   +2 more
openaire   +2 more sources

Mutations of Key Functional Residues in CRM1/XPO1 Differently Alter Its Intranuclear Localization and the Nuclear Export of Endogenous Cargos

Biomolecules
CRM1 (XPO1) has been well-characterized as a shuttling receptor that mediates the export of protein and RNA cargos to the cytoplasm, and previous analyses have pinpointed several key residues (A541, F572, K568, S1055, and Q742) that modulate CRM1 export ...
Miren Josu Omaetxebarria, Maria Sendino, Liher Arrizabalaga, Irune Mota, Ana Maria Zubiaga, José Antonio Rodríguez   +5 more
doaj   +1 more source