Results 41 to 50 of about 18,104 (240)

CRM1 mediates nuclear-cytoplasmic shuttling of mature microRNAs [PDF]

Proceedings of the National Academy of Sciences, 2009
Drosha-processed microRNAs (miRNAs) have been shown to be exported from the nucleus to the cytoplasm by Exportin 5, where they are processed a second time to generate mature miRNAs. In this work we show that miRNAs also use CRM1 for nuclear-cytoplasmic shuttling.
Daniela, Castanotto, Robert, Lingeman, Arthur D, Riggs, John J, Rossi   +3 more
openaire   +2 more sources

Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity

Cells, 2019
DEAD-box helicase 3, X-linked (DDX3X) regulates the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR)-mediated antiviral response, but can also be a host factor contributing to the replication of viruses of significance to human health, such as ...
Steven M. Heaton, Sarah C. Atkinson, Melissa N. Sweeney, Sundy N. Y. Yang, David A. Jans, Natalie A. Borg   +5 more
doaj   +1 more source

Cytoplasmic PML promotes TGF-β-associated epithelial–mesenchymal transition and invasion in prostate cancer [PDF]

, 2016
Epithelial–mesenchymal transition (EMT) is a key event that is involved in the invasion and dissemination of cancer cells. Although typically considered as having tumour-suppressive properties, transforming growth factor (TGF)-β signalling is altered ...
A G Pockley, A K Miles, A Kakizuka, B Terris, BR Henderson, C Gurrieri, C Johnson, CD Morrison, CH Heldin, D G Powe, D J Boocock, DG Altman, DR Principe, G Hulman, G Jin, G van Schalkwyk, H de Thé, H Son, HK Lin, J Borrow, J Hulman, J Massagué, J Massagué, JJ Christiansen, JP Thiery, Jr McCarty KS, JYH Chan, L Kubiczkova, M E Buczek, M Mazza, MG Mathieu, P Salomoni, PM Siegel, R C Rees, R Derynck, R Parkinson, RL Camp, S Grünert, S Lamouille, S Nisole, T Regad, T Regad, V Lallemand-Breitenbach, W Green, WC Yuan, Y Katakura   +45 more
core   +1 more source

An update to the CRM1 cargo/NES database NESdb

Molecular Biology of the Cell, 2021
The nuclear export receptor CRM1 transports hundreds to thousands of diverse functioning macromolecules (proteins and RNAs) from the nucleus to the cytoplasm.
H. Fung, Ashley B. Niesman, Y. Chook
semanticscholar   +1 more source

XPO1 (exportin 1 (CRM1 homolog, yeast)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on XPO1 (exportin 1 (CRM1 homolog, yeast)), with data on DNA, on the protein encoded, and where the gene is implicated.
Ruggiero A, Giubettini M, Lavia P
openaire   +4 more sources

CRM1 Is a Direct Cellular Target of the Natural Anti-cancer Agent Plumbagin

Journal of Pharmacological Sciences, 2014
Plumbagin, a naphthoquinone derived from the medicinal plant Plumbago zeylanica, has been shown to exert anti-cancer and anti-proliferative activities in vitro as well as in animal tumor models.
Xuejiao Liu, Mingshan Niu, Xiaoyu Xu, Wei Cai, Lingyu Zeng, Xiuping Zhou, Rutong Yu, Kailin Xu   +7 more
doaj   +1 more source

Pharmacological treatment with inhibitors of nuclear export enhances the antitumor activity of docetaxel in human prostate cancer [PDF]

, 2017
Background and aims: Docetaxel (DTX) modestly increases patient survival of metastatic castration-resistant prostate cancer (mCRPC) due to insurgence of pharmacological resistance. Deregulation of Chromosome Region Maintenance (CRM-1)/ exportin-1 (XPO-1)-
Argueta, Christian, BIORDI, ASSUNTA LEDA, Biordi, Leda Assunta, Colapietro, Alessandro, Festuccia, Claudio, Flati, Vincenzo, Gravina, Giovanni Luca, Iorio, Roberto, Kauffman, Michael, Landesman, Yosef, Mancini, Andrea, Marampon, Francesco, Pompili, Simona, Sferra, Roberta, Shacham, Sharon   +14 more
core   +2 more sources

Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export

Cell Reports, 2015
CRM1 is the major nuclear export receptor. During translocation through the nuclear pore, transport complexes transiently interact with phenylalanine-glycine (FG) repeats of multiple nucleoporins. On the cytoplasmic side of the nuclear pore, CRM1 tightly
Sarah A. Port, Thomas Monecke, Achim Dickmanns, Christiane Spillner, Romina Hofele, Henning Urlaub, Ralf Ficner, Ralph H. Kehlenbach   +7 more
doaj   +1 more source

Molecular Control of the Amount, Subcellular Location and Activity State of Translation Elongation Factor 2 (eEF-2) in Neurons Experiencing Stress [PDF]

, 2013
Eukaryotic elongation factor 2 (eEF-2) is an important regulator of the protein translation machinery wherein it controls the movement of the ribosome along the mRNA.
Argüelles-Castilla, Sandro, Ayala, Antonio, Camandola, Simonetta, Cutler, Roy G., Hutchison, Emmette R., Mattson, Mark P.   +5 more
core   +1 more source

CRM1 Promotes Capsid Disassembly and Nuclear Envelope Translocation of Adenovirus Independently of Its Export Function

Journal of Virology, 2021
A role of nucleoporins and of soluble transport factors in adenoviral genome import into the nucleus of infected cells in interphase has previously been established. The nuclear export receptor CRM1 promotes genome import, but its precise function is not
Floriane Lagadec, I. Carlon-Andres, J. Ragues, S. Port, H. Wodrich, R. Kehlenbach   +5 more
semanticscholar   +1 more source