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Exportin 1 (XPO1) Expression and Effectiveness of XPO1 Inhibitor Against Canine Lymphoma Cell Lines [PDF]

Veterinary Sciences
Lymphoma is the most common neoplasm of lymphoid tissues in dogs. Exportin 1 (XPO1) is an important major nuclear receptor for exporting proteins and RNA species.
Hardany Primarizky, Satoshi Kambayashi, Kenji Baba, Kenji Tani, Masaru Okuda   +4 more
doaj   +3 more sources

Modulation of anti-tumour immunity by XPO1 inhibitors [PDF]

Exploration of Targeted Anti-tumor Therapy
Exportin-1 (XPO1) is a nuclear export protein that, when overexpressed, can facilitate cancer cell proliferation and survival and is frequently overexpressed or mutated in cancer patients.
Jack G. Fisher, Laura G. Bartlett, Trinayan Kashyap, Christopher J. Walker, Salim I. Khakoo, Matthew D. Blunt   +5 more
doaj   +4 more sources

Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia [PDF]

Journal of Hematology & Oncology, 2021
Background Exportin 1 (XPO1/CRM1) is a key mediator of nuclear export with relevance to multiple cancers, including chronic lymphocytic leukemia (CLL). Whole exome sequencing has identified hot-spot somatic XPO1 point mutations which we found to disrupt ...
Janek S. Walker, Zachary A. Hing, Bonnie Harrington, Jordan Baumhardt, Hatice Gulcin Ozer, Amy Lehman, Brian Giacopelli, Larry Beaver, Katie Williams, Jordan N. Skinner, Casey B. Cempre, Qingxiang Sun, Sharon Shacham, Benjamin R. Stromberg, Matthew K. Summers, Lynne V. Abruzzo, Laura Rassenti, Thomas J. Kipps, Sameer Parikh, Neil E. Kay, Kerry A. Rogers, Jennifer A. Woyach, Vincenzo Coppola, Yuh Min Chook, Christopher Oakes, John C. Byrd, Rosa Lapalombella   +26 more
doaj   +5 more sources

XPO1-dependent nuclear export as a target for cancer therapy [PDF]

Journal of Hematology & Oncology, 2020
Cellular homeostasis requires the proper nuclear-cytoplasmic partitioning of large molecules, which is often deregulated in cancer. XPO1 is an export receptor responsible for the nuclear-cytoplasmic transport of hundreds of proteins and multiple RNA ...
Nancy G. Azizian, Yulin Li
doaj   +3 more sources

CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma [PDF]

iScience
Summary: Cellular senescence’s role in clear cell renal carcinoma (ccRCC) remains unclear. We identify CCT3 as a driver of ccRCC progression by enhancing XPO1 stability via correct folding, confirmed by Co-IP and GST pull-down.
Yilong Cao, Chao Xu, Yuepeng Liu, Bei Shi, Xiaoling Li, Jiehan Li, Bowei Zhang, Zeyuan Zhang, Shengtao Dai, Qingyun Sun, Junfei Gu   +10 more
doaj   +2 more sources

NRF2 activators and the inhibitor of nuclear export, selinexor, restrict coronaviruses by targeting a network involving ACE2, TMPRSS2, and XPO1 through an NRF2-independent mechanism [PDF]

Communications Biology
Nuclear factor erythroid 2–related factor 2 (NRF2) plays important roles in antiviral host cell defenses. We assessed the potential of the NRF2 activators 4-octyl itaconate (4OI), bardoxolone (BARD), and sulforaphane (SFN), and the exportin-1 (XPO1 ...
Fakhar H. Waqas, Leandro Silva da Costa, Francisco J. Zapatero-Belinchón, Madalina E. Carter-Timofte, Lisa Lasswitz, Demi van der Horst, Rebecca Möller, Julia Dahlmann, Ruth Olmer, Robert Geffers, Gisa Gerold, David Olagnier, Frank Pessler   +12 more
doaj   +2 more sources

Exportin 1 as a Therapeutic Target to Overcome Drug Resistance in Lung Cancer [PDF]

Cells
Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related mortality, with therapeutic resistance continuing to limit long-term responses.
Maria Vittoria Di Marco, Alessandro Gasparetto, Roberto Chiarle, Claudia Voena   +3 more
doaj   +2 more sources

Mobilization of nuclear antiviral factors by exportin XPO1 via the actin network inhibits RNA virus replication. [PDF]

PLoS Pathogens
The intricate interplay between +RNA viruses and their hosts involves the exploitation of host resources to build virus-induced membranous replication organelles (VROs) in cytosol of infected cells.
Biao Sun, Cheng-Yu Wu, Paulina Alatriste Gonzalez, Peter D Nagy   +3 more
doaj   +2 more sources

XPO1-dependency of DEK::NUP214 leukemia. [PDF]

Leukemia
Abstract The nuclear export protein XPO1 interacts with nucleoporin 214 (NUP214) and has been implicated in the pathogenesis of SET::NUP214 acute myeloid leukemia (AML). We evaluated DEK::NUP214 (DN), characterizing a distinct AML entity, for its dependency on XPO1 in human AML models.
Charles Cano F, Kloos A, Hebalkar RY, Plenge T, Geffers R, Kirchhoff H, Kattre N, Görlich K, Büsche G, Shcherbata HR, Scherr M, Döhner K, Gabdoulline R, Heuser M.   +13 more
europepmc   +3 more sources

Autophagy modulates glioblastoma cell sensitivity to Selinexor-mediated XPO1 inhibition. [PDF]

Neuro Oncol
Abstract Background Selinexor is a selective inhibitor of exportin-1 (XPO1), a key mediator of the nucleocytoplasmic transport for molecules critical to tumor cell survival. Selinexor’s lethality is generally associated with the induction of apoptosis, and in some cases, with autophagy-induced ...
Tang Y, Sprinzen L, Terada Y, Kiang KM, Li C, Zeng Y, Liu F, Zhou H, Liang X, Zhang J, Pieper RO, Chen B, Zhang L.   +12 more
europepmc   +3 more sources