Genome-wide RNAi screen identifies broadly-acting host factors that inhibit arbovirus infection [PDF]
, 2014 Vector-borne viruses are an important class of emerging and re-emerging pathogens; thus, an improved understanding of the cellular factors that modulate infection in their respective vertebrate and insect hosts may aid control efforts.
Cherry, Sara +8 more
core +4 more sources
DDX17 nucleocytoplasmic shuttling promotes acquired gefitinib resistance in non-small cell lung cancer cells via activation of β-catenin [PDF]
, 2017 Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are effective for non-small cell lung cancer (NSCLC) patients with EGFR mutations, almost all these patients will eventually develop acquired resistance to EGFR-TKI. However,
Chen, Yan +11 more
core +2 more sources
Inhibition of XPO-1 Mediated Nuclear Export through the Michael-Acceptor Character of Chalcones
Pharmaceuticals, 2021 The nuclear export receptor exportin-1 (XPO1, CRM1) mediates the nuclear export of proteins that contain a leucine-rich nuclear export signal (NES) towards the cytoplasm.
Marta Gargantilla +6 more
doaj +1 more source
A Low Frequency of Losses in 11q Chromosome Is Associated with Better Outcome and Lower Rate of Genomic Mutations in Patients with Chronic Lymphocytic Leukemia [PDF]
, 2015 This work was supported by grants from the Spanish Fondo de Investigaciones Sanitarias FIS09/01543, PI12/00281 and PI15/01471, Instituto de Salud Carlos III (ISCIII), European Regional Development Fund (ERDF) "Una manera de hacer Europa", Proyectos de ...
Hernández Sánchez, María +3 more
core +2 more sources
XPO1, therapeutic...and prognostic target in sarcomas
Oncoscience, 2016 In a recent issue of Oncotarget [1], Nakayama et al. showed the anti-tumor activity of selinexor, an inhibitor of exportin 1, against a wide variety of sarcoma preclinical models, including several pathological subtypes of soft tissue sarcomas (STS).
Bertucci, François +2 more
openaire +3 more sources
Targeting Nuclear Exporter Protein XPO1/CRM1 in Gastric Cancer [PDF]
International Journal of Molecular Sciences, 2019 Gastric cancer remains an unmet clinical problem in urgent need of newer and effective treatments. Here we show that the nuclear export protein, Exportin 1 (XPO1, chromosome region maintenance 1 or CRM1), is a promising molecular target in gastric cancer.
Rachel Sexton +12 more
openaire +2 more sources
PLoS ONE, 2015 The DEAD-box RNA helicase Ded1, which is essential in yeast and known as DDX3 in humans, shuttles between the nucleus and cytoplasm and takes part in several basic processes including RNA processing and translation.
Glenn Hauk, Gregory D Bowman
doaj +1 more source
Biallelic BIRC3 inactivation in chronic lymphocytic leukaemia patients with 11q deletion identifies a subgroup with very aggressive disease. [PDF]
, 2018 Not ...
Bomben, R +24 more
core +1 more source
XPO1 Expression Is a Poor-Prognosis Marker in Pancreatic Adenocarcinoma [PDF]
Journal of Clinical Medicine, 2019 Pancreatic adenocarcinoma (PAC) is one of the most aggressive human cancers and new systemic therapies are urgently needed. Exportin-1 (XPO1), which is a member of the importin-β superfamily of karyopherins, is the major exporter of many tumor suppressor proteins that are involved in the progression of PAC.
Birnbaum, David Jérémie +4 more
openaire +3 more sources
Give me a SINE: how Selective Inhibitors of Nuclear Export modulate autophagy and aging
Molecular & Cellular Oncology, 2018 Autophagy is a cellular recycling process leading to lysosomal degradation of damaged macromolecules, which can protect cells against aging. The transcription factor EB (TFEB), a major transcriptional regulator of genes involved in autophagy and ...
A.V. Kumar +5 more
doaj +1 more source