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Frontiers in Bioscience-Landmark, 2023 Background: Pyroptosis plays a crucial role in anti-tumor immunity and in formation of the immune microenvironment. However, whether pyroptosis is involved in the progression of clear cell renal cell carcinoma (ccRCC) is still unclear.
Jinpeng Ma +12 more
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Frontiers in Oncology, 2022 Radiotherapy is one of the most effective and frequently used treatments for a wide range of cancers. In addition to its direct anti-cancer cytotoxic effects, ionising radiation can augment the anti-tumour immune response by triggering pro-inflammatory ...
Charleen M. L. Chan Wah Hak +5 more
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Targeted cancer therapies [PDF]
Chinese Journal of Cancer, 2011 With unprecedented understanding of molecular events underlying human cancer in this genomic era, a large number of drugs specifically targeting hypothesized oncogenic drivers to which tumors are potentially addicted to have been developed and continue to be developed.
Yan, Li, Rosen, Neal, Arteaga, Carlos
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Targeted Perfusion Therapy in Spinal Cord Trauma. [PDF]
, 2020 We review state-of-the-art monitoring techniques for acute, severe traumatic spinal cord injury (TSCI) to facilitate targeted perfusion of the injured cord rather than applying universal mean arterial pressure targets.
Papadopoulos, MC, Saadoun, S
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Ursodeoxycholic acid suppresses the malignant progression of colorectal cancer through TGR5-YAP axis
Cell Death Discovery, 2021 The Hippo/YAP pathway plays an important role in the development of cancers. Previous studies have reported that bile acids can activate YAP (Yes Associated Protein) to promote tumorigenesis and tumor progression.
Huan Zhang +4 more
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Cholesterol activates the Wnt/PCP-YAP signaling in SOAT1-targeted treatment of colon cancer
Cell Death Discovery, 2021 Intracellular free cholesterol can be converted to cholesteryl ester and stored as lipid droplets through SOAT1-mediated esterification. Compelling evidence implicate targeting SOAT1 as a promising therapeutic strategy for cancer management.
Huanji Xu +4 more
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Geburtshilfe und Frauenheilkunde, 2015 Bisphosphonates and denosumab are well established components of the therapy for osteoporosis and osseous metastases. Their relevance in the adjuvant situation for breast cancer patients is being discussed in part controversially due to the heterogeneous nature of the available data.
J, Salmen, M, Banys-Paluchowski, T, Fehm
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Cell Death Discovery, 2021 Lipid homeostasis plays a fundamental role in the development of hepatocellular carcinoma (HCC). However, the mechanisms that regulate lipid homeostasis to avoid lipotoxicity in HCC remain elusive.
Meiling Ren +4 more
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Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment
Journal of Experimental & Clinical Cancer Research, 2021 Background Serotonin signaling has been associated with tumorigenesis and tumor progression. Targeting the serotonin transporter to block serotonin cellular uptake confers antineoplastic effects in various tumors, including colon cancer.
Di Ye +5 more
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Targeted Radionuclide Therapy [PDF]
Cancers, 2011 Targeted radiotherapy is an evolving and promising modality of cancer treatment. The killing of cancer cells is achieved with the use of biological vectors and appropriate radionuclides. Among the many advantages of this approach are its selectiveness in delivering the radiation to the target, relatively less severe and infrequent side effects, and the
Ersahin, Devrim +2 more
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