Results 21 to 30 of about 1,156,734 (317)
BMC Medicine, 2022 AbstractTargeted therapy is the key for improving overall survival while decreasing the undesirable adverse effects of cancer treatment. Patients who received matched targeted therapies showed dramatically improved overall survival (OS) and progression-free survival (PFS) compared to those without matched therapies.
Zhijun Zhou, Min Li
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OncoImmunology, 2023 Despite breakthroughs in immune checkpoint inhibitors (ICI), the majority of tumors, including those poorly infiltrated by CD8+ T cells or heavily infiltrated by immunosuppressive immune effector cells, are unlikely to result in clinically meaningful ...
Debayan Mukherjee +14 more
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Targeted Therapies in Melanoma [PDF]
Surgical Oncology Clinics of North America, 2015 Advances in understanding the biology of melanoma have provided great insights about the mechanisms of chemoresistance and its genetic heterogeneity in parallel with advances in drug design culminating in recent major treatment breakthroughs using small molecules inhibitors in metastatic melanoma (MM).
Stergios J, Moschos, Ramya, Pinnamaneni
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Molecular Therapy: Oncolytics, 2021 Prostate cancers are considered “cold” tumors characterized by minimal T cell infiltrates, absence of a type I interferon (IFN) signature, and the presence of immunosuppressive cells.
Nicola E. Annels +8 more
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Recist and targeted therapy [PDF]
Acta Radiologica, 2009 Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract.
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Targeted cancer therapies [PDF]
Chinese Journal of Cancer, 2011 With unprecedented understanding of molecular events underlying human cancer in this genomic era, a large number of drugs specifically targeting hypothesized oncogenic drivers to which tumors are potentially addicted to have been developed and continue to be developed.
Yan, Li, Rosen, Neal, Arteaga, Carlos
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Targeted therapy and Immunotherapy in Advanced Endometrial cancer
, 2022 Endometrial cancer is the most common gynaecological cancer in western countries. The prevalence of EC is increasing at a rate of 1–2% every year. Advanced endometrial cancer has a 5-year survival rate of 59.6 percent for stage III disease and 28.6 ...
Algazzar, Mohab Hesham Youssef Ebrahim
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Role of oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer
Molecular Cancer, 2021 Colorectal cancer (CRC) is a heterogeneous disease at the cellular and molecular levels. Kirsten rat sarcoma (KRAS) is a commonly mutated oncogene in CRC, with mutations in approximately 40% of all CRC cases; its mutations result in constitutive ...
Gongmin Zhu +4 more
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What role does pyroptosis play in cancer?
Molecular Metabolism, 2022 Background: Pyroptosis has been attracting much attention recently. We have briefly compared its differences and similarities with other programmed deaths and the process of its study. With further exploration of the caspase family, including caspase-1/3/
Chen Huang, Jian Li, Chenliang Zhang
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Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy
Frontiers in Oncology, 2022 Cholesterol metabolism is often dysregulated in cancer. Squalene monooxygenase (SQLE) is the second rate-limiting enzyme involved in cholesterol synthesis.
Yuheng Zou +4 more
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