Results 1 to 10 of about 647,048 (167)

Pyroptosis-Related Subtypes Predict the Response of Clear Cell Renal Cell Carcinoma to Targeted Therapy

Frontiers in Bioscience-Landmark, 2023
Background: Pyroptosis plays a crucial role in anti-tumor immunity and in formation of the immune microenvironment. However, whether pyroptosis is involved in the progression of clear cell renal cell carcinoma (ccRCC) is still unclear.
Jinpeng Ma, Zhijian Kang, Guang Yang, Xinyue Wang, Minggui Si, Yuting Wang, Guangbin Li, Shiyu Bai, Fanshu Zeng, Min Li, Ziqi Wang, Lu Wang, Wanhai Xu   +12 more
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Molecular Targets for AIDS Therapy [PDF]

Science, 1990
The development of antiretroviral therapy against acquired immunodeficiency syndrome (AIDS) has been an intense research effort since the discovery of the causative agent, human immunodeficiency virus (HIV). A large array of drugs and biologic substances can inhibit HIV replication in vitro.
Mitsuya, H., Yarchoan, R., Broder, S.
openaire   +3 more sources

Ursodeoxycholic acid suppresses the malignant progression of colorectal cancer through TGR5-YAP axis

Cell Death Discovery, 2021
The Hippo/YAP pathway plays an important role in the development of cancers. Previous studies have reported that bile acids can activate YAP (Yes Associated Protein) to promote tumorigenesis and tumor progression.
Huan Zhang, Huanji Xu, Chenliang Zhang, Qiulin Tang, Feng Bi   +4 more
doaj   +1 more source

Cholesterol activates the Wnt/PCP-YAP signaling in SOAT1-targeted treatment of colon cancer

Cell Death Discovery, 2021
Intracellular free cholesterol can be converted to cholesteryl ester and stored as lipid droplets through SOAT1-mediated esterification. Compelling evidence implicate targeting SOAT1 as a promising therapeutic strategy for cancer management.
Huanji Xu, Hongwei Xia, Sheng Zhou, Qiulin Tang, Feng Bi   +4 more
doaj   +1 more source

Simultaneously targeting SOAT1 and CPT1A ameliorates hepatocellular carcinoma by disrupting lipid homeostasis

Cell Death Discovery, 2021
Lipid homeostasis plays a fundamental role in the development of hepatocellular carcinoma (HCC). However, the mechanisms that regulate lipid homeostasis to avoid lipotoxicity in HCC remain elusive.
Meiling Ren, Huanji Xu, Hongwei Xia, Qiulin Tang, Feng Bi   +4 more
doaj   +1 more source

Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment

Journal of Experimental & Clinical Cancer Research, 2021
Background Serotonin signaling has been associated with tumorigenesis and tumor progression. Targeting the serotonin transporter to block serotonin cellular uptake confers antineoplastic effects in various tumors, including colon cancer.
Di Ye, Huanji Xu, Hongwei Xia, Chenliang Zhang, Qiulin Tang, Feng Bi   +5 more
doaj   +1 more source

Targeted Molecular Therapies for SBMA [PDF]

Journal of Molecular Neuroscience, 2015
Spinal and bulbar muscular atrophy (SBMA) is a late-onset neuromuscular disease caused by a polyglutamine expansion in the androgen receptor gene which results in progressive spinal and bulbar motor neuron degeneration, and muscle atrophy. Although the causative genetic defect is known, until recently, the molecular pathogenesis of the disease was ...
Rinaldi, C, Malik, B, Greensmith, L
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Revolutionizing cancer care strategies: immunotherapy, gene therapy, and molecular targeted therapy [PDF]

Molecular Biology Reports
Aisha Naeem
exaly   +2 more sources

Molecular imaging and targeted therapies [PDF]

Biochemical Pharmacology, 2010
Targeted therapeutic and imaging agents are becoming more prevalent, and are used to treat increasingly smaller segments of the patient population. This has lead to dramatic increases in the costs for clinical trials. Biomarkers have great potential to reduce the numbers of patients needed to test novel targeted agents by predicting or identifying non ...
David L, Morse, Robert J, Gillies
openaire   +2 more sources

Autophagic sequestration of SQSTM1 disrupts the aggresome formation of ubiquitinated proteins during proteasome inhibition

Cell Death and Disease, 2022
Aggresome formation is a protective cellular response to counteract proteasome dysfunction by sequestering misfolded proteins and reducing proteotoxic stress.
Chenliang Zhang, Chen Huang, Hongwei Xia, Huanji Xu, Qiulin Tang, Feng Bi   +5 more
doaj   +1 more source