Results 21 to 30 of about 6,883,814 (290)
Role of oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer
Molecular Cancer, 2021 Colorectal cancer (CRC) is a heterogeneous disease at the cellular and molecular levels. Kirsten rat sarcoma (KRAS) is a commonly mutated oncogene in CRC, with mutations in approximately 40% of all CRC cases; its mutations result in constitutive ...
Gongmin Zhu +4 more
doaj +1 more source
Targeted Molecular Therapy of GBM
Brain Pathology, 2003 Major advances in molecular biology, cellular biology and genomics have substantially improved our understanding of cancer. Now, these advances are being translated into therapy. Targeted therapy directed at specific molecular alterations is already creating a shift in the treatment of cancer patients.
Paul S, Mischel, Timothy F, Cloughesy
openaire +3 more sources
Cardiovascular molecular imaging [PDF]
, 2013 Although there have been significant improvements in the treatment of cardiovascular diseases they still remain the main cause of morbidity and mortality globally. Currently available diagnostic approaches may not be adequate to detect pathologic changes
Khanicheh, Elham
core +1 more source
Molecular classification and molecular targeted therapy of cancer [PDF]
Frontiers of Medicine, 2013 Various molecular analytical techniques have providedmore and more information which is necessary for theaccurate classification of diseases. Such informationhas enabled researchers to shift from morphology-based classification to molecular characteristics-basedclassification, also known as molecular classification.Molecular classifications of diseases can ...
Miao, Xu, Jianyong, Shao, Yixin, Zeng
openaire +2 more sources
A Highlight of the Mechanisms of Immune Checkpoint Blocker Resistance
Frontiers in Cell and Developmental Biology, 2020 In recent years, as our understanding of tumor immunology is continuously improved, immunotherapy has come to the center stage of cancer therapy and is deemed as the most promising approach for cancer control.
Qian Huang +4 more
doaj +1 more source
Frontiers in Oncology, 2022 While PARP inhibitor (PARPi) therapies have shown promising results in the treatment of high-grade serous ovarian cancer (HGSOC) harboring homologous recombination deficiencies, primary resistance to PARPi frequently occurs and even initial responders ...
Yaxun Jia +6 more
doaj +1 more source
Molecules, 2023 Encoded by the MEN1 gene, menin protein is a fusion protein that is essential for the oncogenic transformation of mixed-lineage leukemia (MLL) and leads to acute leukemia (AL). Therefore, accumulating evidence has demonstrated that inhibition of the high-
Qing Shi +4 more
doaj +1 more source
Major roles of the circadian clock in cancer
Cancer Biology & Medicine, 2023 Circadian rhythms are natural rhythms that widely exist in all creatures, and regulate the processes and physiological functions of various biochemical reactions. The circadian clock is critical for cancer occurrence and progression.
Chen Huang +4 more
doaj +1 more source
Chinese Medicine, 2021 Background Vascular cognitive dysfunction in patients with vascular dementia (VD) is a kind of severe cognitive dysfunction syndrome caused by cerebrovascular diseases.
Yue Qiu +15 more
doaj +1 more source
Molecular-targeted therapy for cancer
Chinese Journal of Cancer, 2010 Molecular-targeted therapy is a newly developed approach for cancer therapy. With the advantages of lower side effects and higher performance, this approach has become a critical focus of cancer research. There are various molecules that can be treated as therapeutic targets for cancer.
Bing, Dong, Yi-Min, Zhu
openaire +2 more sources