Results 31 to 40 of about 631,529 (311)

T-cell infiltration in the central nervous system and their association with brain calcification in Slc20a2-deficient mice

Frontiers in Molecular Neuroscience, 2023
Primary familial brain calcification (PFBC) is a rare neurodegenerative and neuropsychiatric disorder characterized by bilateral symmetric intracranial calcification along the microvessels or inside neuronal cells in the basal ganglia, thalamus, and ...
Yi Zhang, Yi Zhang, Yaqiong Ren, Yueni Zhang, Yueni Zhang, Ying Li, Ying Li, Chao Xu, Chao Xu, Ziyue Peng, Ziyue Peng, Ying Jia, Ying Jia, Shupei Qiao, Shupei Qiao, Zitong Zhang, Zitong Zhang, Lei Shi, Lei Shi   +18 more
doaj   +1 more source

Molecular-targeted therapy for cancer

Chinese Journal of Cancer, 2010
Molecular-targeted therapy is a newly developed approach for cancer therapy. With the advantages of lower side effects and higher performance, this approach has become a critical focus of cancer research. There are various molecules that can be treated as therapeutic targets for cancer.
Bing, Dong, Yi-Min, Zhu
openaire   +2 more sources

Molecular classification and molecular targeted therapy of cancer [PDF]

Frontiers of Medicine, 2013
Various molecular analytical techniques have providedmore and more information which is necessary for theaccurate classification of diseases. Such informationhas enabled researchers to shift from morphology-based classification to molecular characteristics-basedclassification, also known as molecular classification.Molecular classifications of diseases can ...
Miao, Xu, Jianyong, Shao, Yixin, Zeng
openaire   +2 more sources

Targeting sterol-O-acyltransferase 1 to disrupt cholesterol metabolism for cancer therapy

Frontiers in Oncology, 2023
Cholesterol esterification is often dysregulated in cancer. Sterol O-acyl-transferase 1 (SOAT1) plays an important role in maintaining cellular cholesterol homeostasis by catalyzing the formation of cholesterol esters from cholesterol and long-chain ...
Teng Tu, Hongying Zhang, Huanji Xu
doaj   +1 more source

Molecular targets for therapy in systemic sclerosis [PDF]

Fibrogenesis & Tissue Repair, 2012
Despite significant advances have been made in the recent years regarding organ-specific therapies, there is no approved 'disease-modifying' antifibrotic drug for systemic sclerosis (SSc) available to date. Although non-selective immunosuppressive agents are routinely used to treat patients with SSc, large well-controlled studies are lacking for almost
Iwamoto, Naoki, Distler, Oliver
openaire   +4 more sources

Puerarin Alleviates Vascular Cognitive Impairment in Vascular Dementia Rats

Frontiers in Behavioral Neuroscience, 2021
Cerebral ischemia triggers vascular dementia (VD), which is characterized by memory loss, cognitive deficits, and vascular injury in the brain. Puerarin (Pur) represents the major isoflavone glycoside of Radix Puerariae, with verified neuroprotective ...
Tiantian Zhu, Tiantian Zhu, Tiantian Zhu, Moli Zhu, Moli Zhu, Moli Zhu, Yue Qiu, Yue Qiu, Yue Qiu, Zeqing Wu, Zeqing Wu, Zeqing Wu, Ning Huang, Ning Huang, Ning Huang, Guangrui Wan, Guangrui Wan, Guangrui Wan, Jian Xu, Jian Xu, Jian Xu, Ping Song, Ping Song, Ping Song, Shuangxi Wang, Shuangxi Wang, Shuangxi Wang, Yaling Yin, Yaling Yin, Yaling Yin, Peng Li, Peng Li, Peng Li   +32 more
doaj   +1 more source

Current Trends and Future Prospects of Molecular Targeted Therapy in Head and Neck Squamous Cell Carcinoma

, 2020
In recent years, advances in drug therapy for head and neck squamous cell carcinoma (HNSCC) have progressed rapidly. In addition to cytotoxic anti-cancer agents such as platinum-based drug (cisplatin and carboplatin) and taxane-based drugs (docetaxel and
Naoya Kitamura, Eri Sasabe, Shinya Sento, Yasusei Kudo, Yasumasa Yoshizawa, Tetsuya Yamamoto   +5 more
core   +1 more source

Targeted therapy and Immunotherapy in Advanced Endometrial cancer

, 2022
Endometrial cancer is the most common gynaecological cancer in western countries. The prevalence of EC is increasing at a rate of 1–2% every year. Advanced endometrial cancer has a 5-year survival rate of 59.6 percent for stage III disease and 28.6 ...
Algazzar, Mohab Hesham Youssef Ebrahim
core  

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Synergistic activation of bat SARS-like coronaviruses spike protein by elastase and TMPRSS2

Scientific Reports
Although numerous sarbecoviruses have been identified in bats, but most lack the ability to infect human cells. Some barriers limit coronavirus zoonosis, including susceptibility to host proteases.
Yuichiro Yamamoto, Tetsuya Inoue, Naoto Sugiyama, Miyu Furukawa, Kaoru Sato, Taishi Onodera, Yoshimasa Takahashi, Takaji Wakita, Masayoshi Fukasawa, Kohji Noguchi   +9 more
doaj   +1 more source