Results 31 to 40 of about 6,883,814 (290)
Diabetes & Vascular Disease Research, 2020 Aims: The objective of this study was to explore the effects of epigallocatechin-3-gallate (EGCG) on type 2 diabetes mellitus (T2DM). Main methods: Male Sprague–Dawley rats were allocated into six groups.
Wenru Li +6 more
doaj +1 more source
Targeting sterol-O-acyltransferase 1 to disrupt cholesterol metabolism for cancer therapy
Frontiers in Oncology, 2023 Cholesterol esterification is often dysregulated in cancer. Sterol O-acyl-transferase 1 (SOAT1) plays an important role in maintaining cellular cholesterol homeostasis by catalyzing the formation of cholesterol esters from cholesterol and long-chain ...
Teng Tu, Hongying Zhang, Huanji Xu
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Frontiers in Molecular Neuroscience, 2023 Primary familial brain calcification (PFBC) is a rare neurodegenerative and neuropsychiatric disorder characterized by bilateral symmetric intracranial calcification along the microvessels or inside neuronal cells in the basal ganglia, thalamus, and ...
Yi Zhang +18 more
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Molecular targets for therapy in systemic sclerosis [PDF]
Fibrogenesis & Tissue Repair, 2012 Despite significant advances have been made in the recent years regarding organ-specific therapies, there is no approved 'disease-modifying' antifibrotic drug for systemic sclerosis (SSc) available to date. Although non-selective immunosuppressive agents are routinely used to treat patients with SSc, large well-controlled studies are lacking for almost
Iwamoto, Naoki, Distler, Oliver
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Puerarin Alleviates Vascular Cognitive Impairment in Vascular Dementia Rats
Frontiers in Behavioral Neuroscience, 2021 Cerebral ischemia triggers vascular dementia (VD), which is characterized by memory loss, cognitive deficits, and vascular injury in the brain. Puerarin (Pur) represents the major isoflavone glycoside of Radix Puerariae, with verified neuroprotective ...
Tiantian Zhu +32 more
doaj +1 more source
Molecular neuroendocrine targets for obesity therapy [PDF]
Current Opinion in Endocrinology, Diabetes and Obesity, 2010 Although energy balance is tightly regulated in order to maintain a specific level of adiposity, the incidence of obesity continues to increase. Consequently, it is essential that effective therapeutics for the treatment and prevention of obesity be developed.
Annette D, de Kloet, Stephen C, Woods
openaire +2 more sources
Targeted therapy and Immunotherapy in Advanced Endometrial cancer
, 2022 Endometrial cancer is the most common gynaecological cancer in western countries. The prevalence of EC is increasing at a rate of 1–2% every year. Advanced endometrial cancer has a 5-year survival rate of 59.6 percent for stage III disease and 28.6 ...
Algazzar, Mohab Hesham Youssef Ebrahim
core
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
Synergistic activation of bat SARS-like coronaviruses spike protein by elastase and TMPRSS2
Scientific ReportsAlthough numerous sarbecoviruses have been identified in bats, but most lack the ability to infect human cells. Some barriers limit coronavirus zoonosis, including susceptibility to host proteases.
Yuichiro Yamamoto +9 more
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Frontiers in Medicine, 2023 BackgroundEarly detection of kidney diseases can be challenging as conventional methods such as blood tests or imaging techniques (computed tomography (CT), magnetic resonance imaging (MRI), or ultrasonography) may be insufficient to assess renal ...
Ying Ding +23 more
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