Results 41 to 50 of about 969,782 (213)

A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers. [PDF]

, 2016
mTOR inhibition has emerged as a promising strategy for head and neck squamous cell carcinomas (HNSCC) treatment. However, most targeted therapies ultimately develop resistance due to the activation of adaptive survival signaling mechanisms limiting the ...
Amornphimoltham, Panomwat, Califano, Joseph A, Callejas-Valera, Juan Luis, Cohen, Ezra E, Gutkind, J Silvio, Iglesias-Bartolomé, Ramiro, Lippman, Scott M, Luo, Ji, Molinolo, Alfredo A, Wang, Zhiyong, Yamaguchi, Kosuke   +10 more
core   +1 more source

Synergistic activation of bat SARS-like coronaviruses spike protein by elastase and TMPRSS2

Scientific Reports
Although numerous sarbecoviruses have been identified in bats, but most lack the ability to infect human cells. Some barriers limit coronavirus zoonosis, including susceptibility to host proteases.
Yuichiro Yamamoto, Tetsuya Inoue, Naoto Sugiyama, Miyu Furukawa, Kaoru Sato, Taishi Onodera, Yoshimasa Takahashi, Takaji Wakita, Masayoshi Fukasawa, Kohji Noguchi   +9 more
doaj   +1 more source

Systemic Therapy in Endometrial Cancer: Recent Advances. [PDF]

, 2013
Endometrial cancer is a chemosensitive disease. Studies have established a clear benefit of chemotherapy in advanced stages and trials are ongoing to define its role in early stages as well.
Bhise, R, Guru Prasad B, B, Kundargi, R, Lakshmaia, KC, Purohit, S, Shetty, R   +5 more
core   +1 more source

Circular RNA circBNC2 inhibits tumorigenesis by modulating ferroptosis and acts as a nanotherapeutic target in prostate cancer

Molecular Cancer
Background Metastasis is a leading cause of cancer-related death in castration-resistant prostate cancer (CRPC) patients. Circular RNAs (circRNAs) have emerged as key regulators of the metastasis of various cancers.
Xiang Pan, Kailai Chen, Wei Gao, Meiqi Xu, Fanlong Meng, Mengyuan Wu, Zi Qi Wang, Yun Qi Li, Wanhai Xu, Manjie Zhang, Yakun Luo   +10 more
doaj   +1 more source

Signature of seven cuproptosis-related lncRNAs as a novel biomarker to predict prognosis and therapeutic response in cervical cancer

Frontiers in Genetics, 2022
Background: Given the high incidence and high mortality of cervical cancer (CC) among women in developing countries, identifying reliable biomarkers for the prediction of prognosis and therapeutic response is crucial.
Xinyu Liu, Xinyu Liu, Lei Zhou, Minghui Gao, Minghui Gao, Shuhong Dong, Shuhong Dong, Yanan Hu, Yanan Hu, Chunjie Hu, Chunjie Hu   +10 more
doaj   +1 more source

EPMA position paper in cancer:current overview and future perspectives [PDF]

, 2015
At present, a radical shift in cancer treatment is occurring in terms of predictive, preventive, and personalized medicine (PPPM). Individual patients will participate in more aspects of their healthcare.
Bubnov, Rostylav, Danesi, Romano, Desiderio, Dominic M., Grech, Godfrey, Hagan, Suzanne, Vittadini, Giorgio, Yoo, Byong Chul, Zhan, Xianquan   +7 more
core   +5 more sources

Circular RNA circSLC39A10 promotes prostate cancer progression by activating Wnt signaling via the miR-936/PROX1/β-catenin axis

Cellular & Molecular Biology Letters
Circular RNAs (circRNAs) play a crucial role in the initiation and development of cancers. Understanding circRNAs’ functions and molecular mechanisms in tumor development is expected to reveal new diagnostic indicators and therapeutic targets of prostate
Kailai Chen, Xiang Pan, Shiheng Zhang, Meiqi Xu, Xi Chen, Feng Pei, Mengyuan Wu, Fanlong Meng, Bin Sun, Manjie Zhang, Yakun Luo   +10 more
doaj   +1 more source

The value of 18F-FDG PET/CT in the systemic evaluation of patients with Rosai–Dorfman disease: a retrospective study and literature review

Orphanet Journal of Rare Diseases, 2023
Background Rosai–Dorfman disease (RDD) is a rare form of non-Langerhans cell histiocytic disease. The aim of this study was to review the characteristics of RDD using 18F-FDG PET/CT and determine its efficacy in the disease management. Results A total of
Xinyu Lu, Rongxi Wang, Zhaohui Zhu
doaj   +1 more source

A prognostic model for cervical cancer based on ferroptosis-related genes

Frontiers in Endocrinology, 2022
BackgroundFerroptosis is widely involved in the occurrence and development of various cancers, but a specific mechanism involving ferroptosis in cervical cancer is still unclear.MethodsBased on the expressions of ferroptosis-related genes, a prognostic ...
Huijun Du, Huijun Du, Yumei Tang, Yumei Tang, Xiaoying Ren, Xiaoying Ren, Fan Zhang, Fan Zhang, Wei Yang, Wei Yang, Le Cheng, Yunan Gao, Yunan Gao   +12 more
doaj   +1 more source

Personalized medicine : the impact on chemistry [PDF]

, 2010
An effective strategy for personalized medicine requires a major conceptual change in the development and application of therapeutics. In this article, we argue that further advances in this field should be made with reference to another conceptual shift,
Marsh, Andrew, Singer, Donald R. J., Taylor, Paul C., Watkins, John   +3 more
core   +1 more source