Results 61 to 70 of about 631,529 (311)

Multi-cohort analysis and experimental study on the function of squalene epoxidase as a ferroptosis inhibitor in HCC

BMC Cancer
Squalene epoxidase (SQLE) drives hepatocellular carcinoma (HCC) development via increased hepatic oxidative stress, a hallmark of ferroptosis. Although investigations have progressed, the precise link between SQLE and ferroptosis in HCC remains ...
Xun Yang, Yidi Wu, Qingxin Zhang, Yunfei Zhou, Shuyuan Chang, Chunhui Zhang, Dabin Liu   +6 more
doaj   +1 more source

Use of 18F-FDG PET/CT to Differentiate Ectopic Adrenocorticotropic Hormone-Secreting Lung Tumors From Tumor-Like Pulmonary Infections in Patients With Ectopic Cushing Syndrome

Frontiers in Oncology, 2021
BackgroundEctopic adrenocorticotropic hormone (ACTH)-secreting lung tumors represent the most common cause of ectopic Cushing syndrome (ECS). Pulmonary opportunistic infections are associated with ECS.
Guozhu Hou, Guozhu Hou, Yuanyuan Jiang, Yuanyuan Jiang, Fang Li, Fang Li, Xin Cheng, Xin Cheng   +7 more
doaj   +1 more source

A View of Molecular Targeted Therapies in Glioblastoma

International Journal of Research Publication and Reviews, 2023
{"references": ["Le Rhun E, Preusser M, Roth P, Reardon DA, van den Bent M, Wen P, Reifenberger G, Weller M. Molecular targeted therapy of glioblastoma. Cancer Treat Rev. 2019 Nov;80:101896. doi: 10.1016/j.ctrv.2019.101896. Epub 2019 Sep 11. PMID: 31541850", "Yang, K., Wu, Z., Zhang, H. et al.
Majumdar, Esha, Chakraborty, Aria
openaire   +2 more sources

Recent Advances in Molecular Diagnostics and Targeted Therapy of Myeloproliferative Neoplasms [PDF]

, 2021
Somatic mutations in JAK2, calreticulin, and MPL genes drive myeloproliferative neoplasms (MPN), and recent technological advances have revealed a heterogeneous genomic landscape with additional mutations in MPN.
Sara C. Meyer, Simona Stivala, Meyer, Sara C., Stivala, Simona   +3 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Long-read sequencing identifies ATXN3 repeat expansions, and transcriptomics reveals disease progression biomarkers and druggable targets for spinocerebellar ataxia type 3

BMC Neurology
Background Hereditary ataxias (HAs) are neurodegenerative disorders characterized by progressive cerebellar degeneration, with autosomal dominant spinocerebellar ataxias (SCAs) representing the most prevalent subtype. SCA3, the most common form worldwide,
Chang Liu, Xin Wang, Chao Xu, Xiaoxiang Liu, Liyan Ke, Ying Li, Hang Zhang, Jianqiang Tan, Senwei Tan, Zitong Zhang, Liang Cheng, Yaqiong Ren, Lei Shi   +12 more
doaj   +1 more source

Scintigraphic Imaging of Neovascularization With 99mTc-3PRGD2 for Evaluating Early Response to Endostar Involved Therapies on Pancreatic Cancer Xenografts In Vivo

Frontiers in Oncology, 2021
BackgroundMolecular imaging targeting angiogenesis can specifically monitor the early therapeutic effect of antiangiogenesis therapy. We explore the predictive values of an integrin αvβ3-targeted tracer, 99mTc-PEG4-E[PEG4-c(RGDfK)]2 (99mTc-3PRGD2), for ...
Xiaona Jin, Xiaona Jin, Chengyan Dong, Kun Zheng, Kun Zheng, Ximin Shi, Ximin Shi, Yu Liu, Yu Liu, Li Huo, Li Huo, Fan Wang, Fang Li, Fang Li   +13 more
doaj   +1 more source

Molecular neuroendocrine targets for obesity therapy [PDF]

Current Opinion in Endocrinology, Diabetes and Obesity, 2010
Although energy balance is tightly regulated in order to maintain a specific level of adiposity, the incidence of obesity continues to increase. Consequently, it is essential that effective therapeutics for the treatment and prevention of obesity be developed.
Annette D, de Kloet, Stephen C, Woods
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Molecular-Targeted Therapies for Hematologic Malignancies [PDF]

Advances in Hematology, 2012
Major advances in the disciplines of hematology, genetics, biochemistry, and chemistry over the past decades have empowered investigators with the background and methods required for development of customized molecular-targeted therapies. The ability to identify signaling pathways that are dysregulated, to determine the associated mutations, and to ...
Kevin D. Bunting, Cheng-Kui Qu, Michael H. Tomasson   +2 more
openaire   +3 more sources