Results 71 to 80 of about 969,782 (213)

Microenvironment and tumor cells: two targets for new molecular therapies of hepatocellular carcinoma. [PDF]

, 2018
Hepatocellular carcinoma (HCC), is one of the most frequent human cancer and is characterized by a high mortality rate. The aggressiveness appears strictly related to the liver pathological background on which cancer develops.
Amicone, Laura, Marchetti, Alessandra
core   +1 more source

Hepatotoxicity of molecular targeted therapy.

Contemporary oncology (Poznan, Poland), 2014
A constant increase in occurrence of neoplasms is observed; hence new methods of therapy are being intensively researched. One of the methods of antineoplastic treatment is molecular targeted therapy, which aims to influence individual processes occurring in cells.
Karczmarek-Borowska, Bożenna, Sałek-Zań, Agata   +1 more
openaire   +2 more sources

Succinate supplementation alleviates liver cancer by inhibiting the FN1/SQLE axis-mediated cholesterol biosynthesis

iScience
Summary: Succinate is a crucial metabolite in the TCA cycle and contributes to cancer development. However, the role of exogenous succinate in hepatocellular carcinoma (HCC) is unclear.
Shuyuan Chang, Ayaka Tomii, Yunfei Zhou, Xun Yang, Yihong Dong, Jun Yan, Aodi Wu, Yumeng Wang, Qingxin Zhang, Hongxue Meng, Lei Yu, Wei Sun, Dabin Liu   +12 more
doaj   +1 more source

Bionanomedicine: A “Panacea” In Medicine? [PDF]

, 2017
Recent advances in nanotechnology, biotechnology, bioinformatics, and materials science have prompted novel developments in the field of nanomedicine. Enhancements in the theranostics, computational information, and management of diseases/disorders are ...
Anurogo, D. (Dito), Ikrar, T. (Taruna), Parikesit, A. A. (Arli)   +2 more
core   +1 more source

Menin facilitates the cell proliferation of bladder cancer via modulating the TFAP2C/β-catenin axis

Genes and Diseases
Bladder cancer (BLCA) is a common malignant tumor of the urinary system, with significant morbidity and mortality rates worldwide. The MEN1 gene, encoding the menin protein, plays a regulatory role in several cancers. However, the role played by menin in
Qing Shi, Xiang Pan, Shiheng Zhang, Mengyuan Wu, Meiqi Xu, Yun-Qi Li, Li Zhong, Zi-Qi Wang, Wanhai Xu, Yakun Luo   +9 more
doaj   +1 more source

Next-generation sequencing of prostate cancer: genomic and pathway alterations, potential actionability patterns, and relative rate of use of clinical-grade testing. [PDF]

, 2019
Despite being one of the most common cancers, treatment options for prostate cancer are limited. Novel approaches for advanced disease are needed. We evaluated the relative rate of use of clinical-grade next generation sequencing (NGS) in prostate cancer,
Carter, Jennifer L, Elkin, Sheryl K, Ikeda, Sadakatsu, Kurzrock, Razelle, Tomson, Brett N   +4 more
core  

Could Upregulated Hsp70 Protein Compensate for the Hsp90-Silence-Induced Cell Death in Glioma Cells? [PDF]

, 2014
The molecular chaperone heat shock protein 90 alpha (Hsp90α) has been recognized in various tumours including glioma. This pilot study using a proteomic approach analyses the downstream effects of Hsp90 inhibition using 17-allylamino-17 ...
Khan, Zarine Jamsher, Munje, Chinmay, Shervington, Amal A, Shervington, Leroy Alexander   +3 more
core   +2 more sources

NAT10 drives hepatocellular carcinoma progression through SQLE-mediated cholesterol biosynthesis and is targetable by remodelin

iScience
Summary: Hepatocellular carcinoma (HCC) is a highly aggressive malignancy characterized by a paucity of therapeutic options. An analysis of multi-omics datasets, including The Cancer Genome Atlas (TCGA), the International Cancer Genome Consortium (ICGC),
Yumeng Wang, Xun Yang, Yihong Dong, Xinxin Yang, Yunjing Hou, Qiang Fu, Jun Yan, Yulu Du, Qingxin Zhang, Yunfei Zhou, Aodi Wu, Shuyuan Chang, Jianwen Xu, Chunhui Zhang, Xiaoyang Hu, Hongxue Meng, Wei Sun, Dabin Liu   +17 more
doaj   +1 more source

KNTC1 initiates a KNTC1/E2F8/MYC positive feedback loop to facilitate tumorigenesis and enhance chemoresistance in bladder cancer

Journal of Experimental & Clinical Cancer Research
Background Bladder cancer (BLCA) is a lethal malignancy frequently challenged by chemoresistance and limited therapeutic options. Kinetochore-associated 1 (KNTC1) has been implicated in cancer, yet its precise role, regulatory mechanism, and therapeutic ...
Kailai Chen, Hecheng Su, Feng Pei, Xi Chen, Meiqi Xu, Fang Chai, Yakun Luo   +6 more
doaj   +1 more source

Targeting RAF dimers in RAS mutant tumors: From biology to clinic

Acta Pharmaceutica Sinica B
RAS mutations occur in approximately 30% of tumors worldwide and have a poor prognosis due to limited therapies. Covalent targeting of KRAS G12C has achieved significant success in recent years, but there is still a lack of efficient therapeutic ...
Huanhuan Yin, Qiulin Tang, Hongwei Xia, Feng Bi   +3 more
doaj   +1 more source