Results 71 to 80 of about 631,529 (311)

An Engineering Approach to Cancer Therapy Using Systemically Delivered siRNA [PDF]

, 2007
The next generation of cancer therapeutics will specifically target processes responsible for the growth and survival of cancer cells. Among the most promising of these molecularly targeted therapeutics are small interfering RNAs (siRNAs). These siRNAs
Bartlett, Derek William
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Targeted Therapy of Sarcoma

Sarcomas represent a heterogeneous group of tumors that are composed of a wide range of tumor types with different natural histories and therapeutic approaches. Recent discoveries have identified specific molecular alterations in the pathogenesis of many
Trent, Jonathan C, Ludwig, Joseph
core   +1 more source

The Auger Effect in Molecular Targeting Therapy

, 2008
Knowledge on the physical and biological aspects of Auger-electron emission is described and the major attempts to use such emitters in cancer therapy are discussed.
Hans Lundqvist, Bo Stenerlöw, Lars Gedda, Lundqvist, Hans,, Stenerlöw, Bo,, Gedda, Lars,   +5 more
core   +1 more source

Targeted Therapy in the Treatment of Pediatric Acute Lymphoblastic Leukemia—Therapy and Toxicity Mechanisms

, 2021
Targeted therapy has revolutionized the treatment of poor-prognosis pediatric acute lymphoblastic leukemia (ALL) with specific genetic abnormalities. It is still being described as a new landmark therapeutic approach.
Kinga Kuśmierczuk, Kinga Bednarz, Katarzyna Ostapińska, Monika Lejman, Joanna Zawitkowska   +4 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Endogenous Coriobacteriaceae enriched by a high-fat diet promotes colorectal tumorigenesis through the CPT1A-ERK axis

npj Biofilms and Microbiomes
A high-fat diet (HFD) may be linked to an increased colorectal cancer (CRC) risk. Stem cell proliferation and adipokine release under inflammatory and obese conditions are the main factors regulating CRC progression.
Qiulin Tang, Huixi Huang, Huanji Xu, Hongwei Xia, Chenliang Zhang, Di Ye, Feng Bi   +6 more
doaj   +1 more source

Molecular Targeted Therapy Approach to Musculoskeletal Tumors

, 2018
The future of cancer treatment is promising. Although marred by years of plateau in outcomes, new avenues have been identified that are poised to change how we treat cancer.
Lindskog, Dieter, Dieter Lindskog, Andrew Koo, Haynes, Monique, Friedlaender, Gary E., Gary E. Friedlaender, Ibe, Izuchukwu, Koo, Andrew, Monique Haynes, Izuchukwu Ibe, Francis Y. Lee, Lee, Francis Y.   +11 more
core   +1 more source

Molecular features of IGHV3-53-encoded antibodies elicited by SARS-CoV-2

, 2020
An elegant paper by Yuan et al., recently published in Science, provides novel insights into the molecular features of neutralizing antibody responses to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).1 According to the principles ...
Michele Catanzaro, Francesca Fagiani, Fagiani, Francesca, Cristina Lanni, Catanzaro, Michele, Lanni, Cristina   +5 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source