Results 91 to 100 of about 631,529 (311)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

[Molecular targeted therapy].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 2006
Until recently, cancer therapy was based on three modalities: surgery, radiotherapy, and cytostatic chemotherapy. In most instances treatment of solid tumors was a surgical domain. For patients with incomplete resection or relapse after surgery, radiotherapy and chemotherapy usually offered only partial response and mostly of limited duration.
Stenner-Liewen F, Zippelius A, Pestalozzi BC, Knuth A   +3 more
openaire   +4 more sources

NAT10 drives hepatocellular carcinoma progression through SQLE-mediated cholesterol biosynthesis and is targetable by remodelin

iScience
Summary: Hepatocellular carcinoma (HCC) is a highly aggressive malignancy characterized by a paucity of therapeutic options. An analysis of multi-omics datasets, including The Cancer Genome Atlas (TCGA), the International Cancer Genome Consortium (ICGC),
Yumeng Wang, Xun Yang, Yihong Dong, Xinxin Yang, Yunjing Hou, Qiang Fu, Jun Yan, Yulu Du, Qingxin Zhang, Yunfei Zhou, Aodi Wu, Shuyuan Chang, Jianwen Xu, Chunhui Zhang, Xiaoyang Hu, Hongxue Meng, Wei Sun, Dabin Liu   +17 more
doaj   +1 more source

Improvements in Clinical Cancer Care Associated with Integration of Personalized Medicine

Background: While adoption of personalized medicine (PM) continues to increase in clinical oncology, there is limited data connecting the level of PM adoption at a given institution to improved clinical outcomes for patients.
Daryl Pritchard, Gary G. Gustavsen, Hina Mohammed, Arushi Agarwal, Thomas D. Brown, Alissa Winzeler   +5 more
core   +1 more source

Aptamer-Targeted Plasmonic Photothermal Therapy of Cancer [PDF]

, 2018
Текст статьи не публикуется в открытом доступе в соответствии с политикой журнала.Novel nanoscale bioconjugates combining unique plasmonic photothermal properties of gold nanoparticles (AuNPs) with targeted delivery using cell specific DNA aptamers have ...
Глазырин, Юрий Евгеньевич, Заблуда, Владимир, Шепелевич, Николай, Белянина, Ирина Валерьевна, Александровский, Александр Сергеевич, Замай, Сергей Сергеевич, Токарев, Николай, Кириченко, Андрей, Гаргаун, Анна, Кичкайло, Анна Сергеевна, Коловская, Ольга Сергеевна, Замай, Галина Сергеевна, Белугин, Кирилл, Бадрин, Евгений, Кичкайло, Анна, Иванченко, Татьяна, Дубынина, Анна, Замай, Татьяна Николаевна, Гаранжа, Ирина, Чанчикова, Наталья, Белкин, Симон, Соколов, Алексей Эдуардович, Березовский, Максим, Карлова, Елена, Озерская, Анастасия   +24 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

KNTC1 initiates a KNTC1/E2F8/MYC positive feedback loop to facilitate tumorigenesis and enhance chemoresistance in bladder cancer

Journal of Experimental & Clinical Cancer Research
Background Bladder cancer (BLCA) is a lethal malignancy frequently challenged by chemoresistance and limited therapeutic options. Kinetochore-associated 1 (KNTC1) has been implicated in cancer, yet its precise role, regulatory mechanism, and therapeutic ...
Kailai Chen, Hecheng Su, Feng Pei, Xi Chen, Meiqi Xu, Fang Chai, Yakun Luo   +6 more
doaj   +1 more source

Menin facilitates the cell proliferation of bladder cancer via modulating the TFAP2C/β-catenin axis

Genes and Diseases
Bladder cancer (BLCA) is a common malignant tumor of the urinary system, with significant morbidity and mortality rates worldwide. The MEN1 gene, encoding the menin protein, plays a regulatory role in several cancers. However, the role played by menin in
Qing Shi, Xiang Pan, Shiheng Zhang, Mengyuan Wu, Meiqi Xu, Yun-Qi Li, Li Zhong, Zi-Qi Wang, Wanhai Xu, Yakun Luo   +9 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Targeting RAF dimers in RAS mutant tumors: From biology to clinic

Acta Pharmaceutica Sinica B
RAS mutations occur in approximately 30% of tumors worldwide and have a poor prognosis due to limited therapies. Covalent targeting of KRAS G12C has achieved significant success in recent years, but there is still a lack of efficient therapeutic ...
Huanhuan Yin, Qiulin Tang, Hongwei Xia, Feng Bi   +3 more
doaj   +1 more source