Results 101 to 110 of about 969,782 (213)

Molecular-targeted therapy for neurodegenerative diseases

Rinsho Shinkeigaku, 2009
Neurodegenerative diseases have been construed as incurable disorders. However, therapeutic development for these diseases is now facing a turning point: analyses of cellular and animal models have provided insights into pathogenesis of neurodegenerative diseases, and have indicated rational therapeutic approaches to them.
openaire   +3 more sources

Molecular targeted therapy for metastatic colorectal cancer: current and evolving approaches. [PDF]

Front Pharmacol, 2023
Li F, Lin Y, Li R, Shen X, Xiang M, Xiong G, Zhang K, Xia T, Guo J, Miao Z, Liao Y, Zhang X, Xie L.   +12 more
europepmc   +1 more source

Challenging issues in molecular-targeted therapy

Therapeutics and Clinical Risk Management, 2009
There are variety of anticancer treatments including chemotherapeutic drugs, which are known to induce cell growth arrest and apoptosis through DNA damage and cytoskeleton toxicity. Meanwhile, histone deacetylase (HDAC) inhibitors could apply their antitumor activity through chromatin remodeling and gene expression modulation that affect the cell cycle
openaire   +4 more sources

Genomic Assessment of Blood-Derived Circulating Tumor DNA in Patients With Colorectal Cancers: Correlation With Tissue Sequencing, Therapeutic Response, and Survival. [PDF]

, 2019
PurposeGenomic alterations in blood-derived circulating tumor DNA (ctDNA) from patients with colorectal cancers were correlated with clinical outcomes.Patients and methodsNext-generation sequencing of ctDNA (54- to 73-gene panel) was performed in 94 ...
Fanta, Paul T, Kato, Shumei, Kurzrock, Razelle, Lanman, Richard B, Leichman, Lawrence, Lippman, Scott M, Okamura, Ryosuke, Raymond, Victoria M, Schwaederlé, Maria C, Talasaz, AmirAli   +9 more
core   +1 more source

Feasibility of a deep-inspiration breath-hold [18F]AlF-NOTA-LM3 PET/CT imaging on upper-abdominal lesions in NET patients: in comparison with respiratory-gated PET/CT

EJNMMI Physics
Purposes To explore the clinical feasibility and efficacy of a deep inspiration breath-hold (BH) PET/CT using [18F]AlF-NOTA-LM3 on upper abdominal lesions in patients with neuroendocrine tumors (NETs).
Haiqiong Zhang, Meixi Liu, Ximin Shi, Jiangyu Ma, Chao Ren, Zhenghai Huang, Ying Wang, Hongli Jing, Li Huo   +8 more
doaj   +1 more source

Post-translational switch of DHCR24 acetylation sustains sterol synthesis and promotes HCC via the 7-ketocholesterol/p62 axis

Cell Reports
Summary: Dysregulated cholesterol synthesis fuels cancer progression, but its precise role in hepatocellular carcinoma (HCC) remains unclear. Here, we identify elevated acetylation of 24-dehydrocholesterol reductase (DHCR24) at Lys254 as a hallmark of ...
Yunfei Zhou, Xinxin Yang, Jianwen Xu, Yidi Wu, Yin Fu, Yihong Dong, Xun Yang, Qiang Fu, Chenxu Guo, Yunjing Hou, Shuyuan Chang, Jun Yan, Ju Ran, Yumeng Wang, Qingxin Zhang, Tomii Ayaka, Lei Yu, Feng Geng, Liuyang Zhao, Xiaoyang Hu, Shuijie Li, Hongxue Meng, Dabin Liu   +22 more
doaj   +1 more source

Molecular targeted therapy for anticancer treatment. [PDF]

Exp Mol Med, 2022
Min HY, Lee HY.
europepmc   +1 more source

Conversion therapy for advanced cholangiocarcinoma in the era of molecular targeted therapy and immune therapy. [PDF]

Hepatobiliary Surg Nutr, 2023
Zhang Z, Zhang W.
europepmc   +1 more source

Potential Molecular Targeted Therapy for Unresectable Hepatocellular Carcinoma. [PDF]

Curr Oncol, 2023
Kumar S, Pandey AK.
europepmc   +1 more source

The potential for liquid biopsies in the precision medical treatment of breast cancer. [PDF]

, 2016
Currently the clinical management of breast cancer relies on relatively few prognostic/predictive clinical markers (estrogen receptor, progesterone receptor, HER2), based on primary tumor biology.
Barrak, Dany K, Elhodaky, Mostafa, Forte, Victoria A, Lang, Julie E, Snow, Anson, Tung, Lily   +5 more
core   +1 more source