Results 11 to 20 of about 6,883,814 (290)
Apatinib for molecular targeted therapy in tumor [PDF]
Drug Design, Development and Therapy, 2015 As tumor angiogenesis is one of the hallmarks of cancer, the inhibition of vascular endothelial growth factor signaling has become an attractive anticancer approach. Apatinib, a small-molecule inhibitor of vascular endothelial growth factor receptor-2, has demonstrated encouraging anticancer activity across a broad range of malignancies, including ...
Zhang H
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EGFR-family expression and implications for targeted radionuclide therapy
, 2008 Summary High expression in the primary tumor of receptors in the EGFR-family is most often also accompanied by a similar high expression in corresponding metastases.
Carlsson, Jörgen,
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Application of the Linear-Quadratic model to targeted radionuclide therapy [PDF]
, 2011 PhDThe principal aim of this work was to test the hypothesis that the Linear-Quadratic (LQ) model of cell survival, developed for external beam radiotherapy (EBRT), could be extended to targeted radionuclide therapy (TRT) in order to predict dose ...
Murray, Iain
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Molecular targeted therapy for anticancer treatment. [PDF]
Exp Mol Med, 2022 Since the initial clinical approval in the late 1990s and remarkable anticancer effects for certain types of cancer, molecular targeted therapy utilizing small molecule agents or therapeutic monoclonal antibodies acting as signal transduction inhibitors ...
Min HY, Lee HY.
europepmc +2 more sources
Developmental trends in targeted radionuclide therapy : Biological aspects
, 2008 Targeted radionuclide therapy of hematopoietic malignancies in the clinical setting has been achieved and similar successes with solid tumors and cells disseminated from them are likely within reach.
Carlsson, Jörgen,
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Advantages of the Combinatorial Molecular Targeted Therapy of Head and Neck Cancer-A Step before Anakoinosis-Based Personalized Treatment. [PDF]
Cancers (Basel), 2023 The molecular initiators of Head and Heck Squamous Cell Carcinoma (HNSCC) are complex. Human Papillomavirus (HPV) infection is linked to an increasing number of HNSCC cases, but HPV-positive tumors generally have a good prognosis.
Kleszcz R.
europepmc +2 more sources
What role does pyroptosis play in cancer?
Molecular Metabolism, 2022 Background: Pyroptosis has been attracting much attention recently. We have briefly compared its differences and similarities with other programmed deaths and the process of its study. With further exploration of the caspase family, including caspase-1/3/
Chen Huang, Jian Li, Chenliang Zhang
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Cancer Cell International, 2021 Background Tumor metastasis is one of the leading reasons of the dismal prognosis of hepatocellular carcinoma (HCC). Epithelial-mesenchymal transition (EMT) is closely associated with tumor metastasis including HCC.
Gongmin Zhu +3 more
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Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy
Frontiers in Oncology, 2022 Cholesterol metabolism is often dysregulated in cancer. Squalene monooxygenase (SQLE) is the second rate-limiting enzyme involved in cholesterol synthesis.
Yuheng Zou +4 more
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Molecular targeted therapy of glioblastoma [PDF]
Cancer Treatment Reviews, 2019 Glioblastomas are intrinsic brain tumors thought to originate from neuroglial stem or progenitor cells. More than 90% of glioblastomas are isocitrate dehydrogenase (IDH)-wildtype tumors. Incidence increases with age, males are more often affected. Beyond rare instances of genetic predisposition and irradiation exposure, there are no known glioblastoma ...
Le Rhun, Emilie +7 more
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