Results 31 to 40 of about 1,817,538 (306)
Cancer stem cells in prostate cancer: implications for targeted therapy [PDF]
, 2017 Prostate cancer (PCa) is the most frequently diagnosed cancer in men and the second most common cause of cancer-related mortality among men in the developed world.
Castelo-Branco, Pedro +5 more
core +1 more source
A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers. [PDF]
, 2016 mTOR inhibition has emerged as a promising strategy for head and neck squamous cell carcinomas (HNSCC) treatment. However, most targeted therapies ultimately develop resistance due to the activation of adaptive survival signaling mechanisms limiting the ...
Amornphimoltham, Panomwat +10 more
core +1 more source
Molecular Therapy: Oncolytics, 2021 Prostate cancers are considered “cold” tumors characterized by minimal T cell infiltrates, absence of a type I interferon (IFN) signature, and the presence of immunosuppressive cells.
Nicola E. Annels +8 more
doaj +1 more source
A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours [PDF]
, 2015 Enhancement of cellular senescence in tumours triggers a stable cell growth arrest and activation of an antitumour immune response that can be exploited for cancer therapy.
Alajati, Abdullah +25 more
core +1 more source
Local generation of hydrogen for enhanced photothermal therapy. [PDF]
, 2018 By delivering the concept of clean hydrogen energy and green catalysis to the biomedical field, engineering of hydrogen-generating nanomaterials for treatment of major diseases holds great promise.
Chen, Danyang +8 more
core +2 more sources
Recist and targeted therapy [PDF]
Acta Radiologica, 2009 Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract.
openaire +3 more sources
Role of oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer
Molecular Cancer, 2021 Colorectal cancer (CRC) is a heterogeneous disease at the cellular and molecular levels. Kirsten rat sarcoma (KRAS) is a commonly mutated oncogene in CRC, with mutations in approximately 40% of all CRC cases; its mutations result in constitutive ...
Gongmin Zhu +4 more
doaj +1 more source
What role does pyroptosis play in cancer?
Molecular Metabolism, 2022 Background: Pyroptosis has been attracting much attention recently. We have briefly compared its differences and similarities with other programmed deaths and the process of its study. With further exploration of the caspase family, including caspase-1/3/
Chen Huang, Jian Li, Chenliang Zhang
doaj +1 more source
Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy
Frontiers in Oncology, 2022 Cholesterol metabolism is often dysregulated in cancer. Squalene monooxygenase (SQLE) is the second rate-limiting enzyme involved in cholesterol synthesis.
Yuheng Zou +4 more
doaj +1 more source
Melanocortin 1 receptor targeted imaging of melanoma with gold nanocages and positron emission tomography [PDF]
, 2018 Purpose: Melanoma is a lethal skin cancer with unmet clinical needs for targeted imaging and therapy. Nanoscale materials conjugated with targeting components have shown great potential to improve tumor delivery efficiency while minimizing undesirable ...
Black, Kvar +8 more
core +2 more sources