Results 51 to 60 of about 3,310,810 (118)

GRPR Drives Metastasis via CRABP2 and FNDC4 Pathways in Lung Adenocarcinoma

Cells
Metastasis is a leading cause of lung adenocarcinoma (LUAD)-related mortality and presents significant challenges for treatment. The gastrin-releasing peptide receptor (GRPR), a member of the G protein-coupled receptor (GPCR) family, has an unclear role ...
Dong-Gun Kim, Eun-Young Choi, Hye-Mi Ahn, Youn-Jae Kim   +3 more
doaj   +1 more source

Targeted Therapy of Melanoma [PDF]

Journal of Investigative Dermatology Symposium Proceedings, 2018
In recent years, the treatment of advanced melanoma has been revolutionized by the introduction of new innovative approaches, namely mutation-based targeted therapy and immune checkpoint blockade by CTLA4 and PD-1/PD-L1 inhibitors. The decade-long era of chemotherapy with very low response rates of 5-20% and short median survival rates of 6-9 months ...
openaire   +2 more sources

Targeted Therapy of Sarcoma

Sarcomas represent a heterogeneous group of tumors that are composed of a wide range of tumor types with different natural histories and therapeutic approaches. Recent discoveries have identified specific molecular alterations in the pathogenesis of many
Trent, Jonathan C, Ludwig, Joseph
core   +1 more source

GABRD promotes hepatocellular carcinoma progression via the IL-10RA/JAK2-STAT3 signaling axis

Cell Death and Disease
Hepatocellular carcinoma (HCC) is a highly aggressive malignancy with a poor prognosis, primarily owing to its capacity of metastasis, underscoring the urgent need to identify novel drivers of HCC progression.
Chengcheng Huang, Weiwei Liu, Zheng Wang, Yingling Liu, Zhenfei Bi, Bin Han, Yue Yan, Shuqi Zhang, Boyu Zhu, Ziyi Zhou, Chaoqun Wang, Lu Zheng, Jing Li   +12 more
doaj   +1 more source

Epigallocatechin-3-gallate ameliorates glucolipid metabolism and oxidative stress in type 2 diabetic rats

Diabetes & Vascular Disease Research, 2020
Aims: The objective of this study was to explore the effects of epigallocatechin-3-gallate (EGCG) on type 2 diabetes mellitus (T2DM). Main methods: Male Sprague–Dawley rats were allocated into six groups.
Wenru Li, Chaonan Zhu, Tianheng Liu, Weifang Zhang, Xu Liu, Peng Li, Tiantian Zhu   +6 more
doaj   +1 more source

Long-read sequencing identifies ATXN3 repeat expansions, and transcriptomics reveals disease progression biomarkers and druggable targets for spinocerebellar ataxia type 3

BMC Neurology
Background Hereditary ataxias (HAs) are neurodegenerative disorders characterized by progressive cerebellar degeneration, with autosomal dominant spinocerebellar ataxias (SCAs) representing the most prevalent subtype. SCA3, the most common form worldwide,
Chang Liu, Xin Wang, Chao Xu, Xiaoxiang Liu, Liyan Ke, Ying Li, Hang Zhang, Jianqiang Tan, Senwei Tan, Zitong Zhang, Liang Cheng, Yaqiong Ren, Lei Shi   +12 more
doaj   +1 more source

Targeted therapy in leukemia [PDF]

Modern Pathology, 2008
Research conducted over the last two decades has yielded a detailed understanding of the molecular lesions that contribute to the malignant transformation of hematopoietic stem cells and committed progenitors into the various forms of acute and chronic leukemia.
openaire   +2 more sources

PRMT5 Methylates and Stabilizes EphA2 via Inhibiting Its Ubiquitination and Degradation to Promote Nasopharyngeal Carcinoma Stem Cell Properties

MedComm
Both PRMT5 and EphA2 proteins are overexpressed and play a crucial role in multiple cancers, and have been used as targets to develop new anticancer drugs. However, the function and significance of the PRMT5–EphA2 interaction are unclear. Here, we report
Zheng‐Zheng Yu, Xue‐Li Mao, Shan‐Shan Lu, Ruo‐Huang Lu, Wei Zhu, Di Wu, Hong Yi, Wei Huang, Qi Wen, Guo‐Xiang Lin, Ting Zeng, Yun‐Xi Peng, Li Yuan, Ting Ran, Juan Feng, Jinwu Peng, Zhi‐Qiang Xiao   +16 more
doaj   +1 more source

Affibody Molecules for Targeted Radionuclide Therapy

, 2011
Carlsson, Jörgen,, Ståhl, Stefan,, Frejd, Fredrik,, Friedman, Mikaela,, Tolmachev, Vladimir,   +4 more
core   +9 more sources

A Targeted Approach to the Complications of Targeted Therapy [PDF]

Journal of Thoracic Oncology, 2019
Mackintosh, John A., Marshall, Henry M., Fong, Kwun M.   +2 more
openaire   +5 more sources