Results 61 to 70 of about 1,817,538 (306)

Systemic Therapy in Endometrial Cancer: Recent Advances. [PDF]

, 2013
Endometrial cancer is a chemosensitive disease. Studies have established a clear benefit of chemotherapy in advanced stages and trials are ongoing to define its role in early stages as well.
Bhise, R, Guru Prasad B, B, Kundargi, R, Lakshmaia, KC, Purohit, S, Shetty, R   +5 more
core   +1 more source

Targeted therapy for breast cancer prevention. [PDF]

, 2013
With a better understanding of the etiology of breast cancer, molecularly targeted drugs have been developed and are being testing for the treatment and prevention of breast cancer.
Brown, Powel H, den Hollander, Petra, Savage, Michelle I   +2 more
core   +2 more sources

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

Tenascin-C Downregulates Wnt Inhibitor Dickkopf-1, Promoting Tumorigenesis in a Neuroendocrine Tumor Model

Cell Reports, 2013
The extracellular matrix molecule tenascin-C (TNC) is a major component of the cancer-specific matrix, and high TNC expression is linked to poor prognosis in several cancers.
Falk Saupe, Anja Schwenzer, Yundan Jia, Isabelle Gasser, Caroline Spenlé, Benoit Langlois, Martial Kammerer, Olivier Lefebvre, Ruslan Hlushchuk, Tristan Rupp, Marija Marko, Michael van der Heyden, Gérard Cremel, Christiane Arnold, Annick Klein, Patricia Simon-Assmann, Valentin Djonov, Agnès Neuville-Méchine, Irene Esposito, Julia Slotta-Huspenina, Klaus-Peter Janssen, Olivier de Wever, Gerhard Christofori, Thomas Hussenet, Gertraud Orend   +24 more
doaj   +1 more source

A Highlight of the Mechanisms of Immune Checkpoint Blocker Resistance

Frontiers in Cell and Developmental Biology, 2020
In recent years, as our understanding of tumor immunology is continuously improved, immunotherapy has come to the center stage of cancer therapy and is deemed as the most promising approach for cancer control.
Qian Huang, Yanna Lei, Xiaoying Li, Fukun Guo, Ming Liu   +4 more
doaj   +1 more source

HOX and PBX gene dysregulation as a therapeutic target in glioblastoma multiforme

BMC Cancer, 2022
Background Glioblastoma multiforme (GBM) is the most common high-grade malignant brain tumour in adults and arises from the glial cells in the brain. The prognosis of treated GBM remains very poor with 5-year survival rates of 5%, a figure which has not ...
Einthavy Arunachalam, William Rogers, Guy R. Simpson, Carla Möller-Levet, Gemma Bolton, Mohammed Ismael, Christopher Smith, Karl Keegen, Izhar Bagwan, Tim Brend, Susan C. Short, Bangxing Hong, Yoshihiro Otani, Balveen Kaur, Nicola Annels, Richard Morgan, Hardev Pandha   +16 more
doaj   +1 more source

Targeted hepatitis C antibody testing interventions: a systematic review and meta-analysis [PDF]

, 2015
Testing for hepatitis C virus (HCV) infection may reduce the risk of liver-related morbidity, by facilitating earlier access to treatment and care.
AG Singal, AH Litwin, BL Cullen, Bryce Smith, C Lacey, CE Kennedy, CW Helsper, CW Helsper, D Lavanchy, David Goldberg, David Hunt, DB Rein, E Blanchet, E Castelnuovo, EE Mast, EM Anderson, Esther Jane Aspinall, European Association for the Study of the Liver (EASL), F Roudot-Thoraval, F Sahajian, F Sahajian, G Defossez, GH Guyatt, H Lewis, HA Innes, J Grebely, J Grebely, J Grebely, JF Perz, Joseph Samuel Doyle, JPT Higgins, KM Hanafiah, L Jones, M Danta, M Hickman, M Karmochine, MA Wakefield, Margaret Elena Hellard, Mark Stoove, MG Ghany, MJ Alter, N Ford, PK Nelson, R Chou, Rebecca Lynn Morgan, SA Villano, Sharon Hutchinson, Stefan Zbyszko Wiktor, Stephen Corson, Tim Nguyen, W Cullen, Yngve Falck-Ytter   +51 more
core   +3 more sources

Pediatric Oncology Nursing Competencies in Latin America and the Caribbean: A Scoping Review to Inform Practice, Education, and Research

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Nurses are central to cancer care for children and adolescents, yet no comprehensive synthesis has defined essential core competencies for pediatric oncology nursing (PON) practice internationally, particularly in Latin America and the Caribbean (LAC).
Luís Carlos Lopes‐Júnior, Edmara Bazoni Soares Maia, Soad Fuentes‐Alabí, Courtney E. Sullivan, Monnie Abraham, Mauricio Maza, Liliana Vásquez Ponce, Regina Aparecida Garcia Lima   +7 more
wiley   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Idiopathic AIDS enteropathy and treatment of gastrointestinal opportunistic pathogens. [PDF]

, 2009
Diarrhea in patients with acquired immune deficiency syndrome (AIDS) has proven to be both a diagnostic and treatment challenge since the discovery of the human immunodeficiency virus (HIV) virus more than 30 years ago.
Cello, John P, Day, Lukejohn W
core