Results 61 to 70 of about 1,156,734 (317)

Low extracellular pH protects cancer cells from ammonia toxicity

Cell Death Discovery
Ammonia is a natural waste product of cellular metabolism which, through its lysosomotropic ability, can have detrimental effects on various cellular functions.
Maria Dravecka, Ingvild Mikkola, Terje Johansen, Ole Morten Seternes, Jakob Mejlvang   +4 more
doaj   +1 more source

The LEDGIN GS-9822 inhibits HIV-2 infection and enhances HIV-2 latency

Microbiology Spectrum
HIV integration is targeted toward active transcription units through the interaction of HIV integrase with the cellular co-factor LEDGF/p75. LEDGINs, small molecule inhibitors of this interaction, reduce HIV-1 integration and retarget residual ...
Anne Bruggemans, Gerlinde Vansant, Eline Pellaers, Paulien Van de Velde, Frauke Christ, Zeger Debyser   +5 more
doaj   +1 more source

Targeted therapy of acute myeloid leukemia

, 2015
Advances in the understanding of the genetic underpinnings of acute myeloid leukemia are rapidly being translated into novel treatment strategies.
Jessica K Altman, Ronan Swords, Carneiro, B.A., Francis J Giles, Altman, Jessica K, Platanias, Leonidas C, Platanias, L.C., Gert Ossenkoppele, Kaplan, Jason B, Kaplan, J.B., Leonidas C Platanias, Jason B Kaplan, Swords, R., Benedito A Carneiro, Swords, Ronan, Altman, J.K., Carneiro, Benedito A, Giles, Francis J, Ossenkoppele, Gert, Ossenkoppele, G., Giles, F.J.   +20 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Exploration of Euscaphic Acid on Non-Hodgkin Lymphoma Based on Network Pharmacology, Molecular Docking and Cell Experiment

Natural Product Communications
Background: Euscaphic acid (EA) has been found that can inhibit the proliferation of various types of tumor cells, including non-Hodgkin's lymphoma (NHL) cells. However, the underlying mechanism of EA in the treatment of NHL is unclear.
Guangru Li, Chunyuan Liang, Yan Liu, Yueyuan Pan, Zhiyuan Li, Guocai Wu, Ruiting Wen   +6 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Multi-cohort analysis and experimental study on the function of squalene epoxidase as a ferroptosis inhibitor in HCC

BMC Cancer
Squalene epoxidase (SQLE) drives hepatocellular carcinoma (HCC) development via increased hepatic oxidative stress, a hallmark of ferroptosis. Although investigations have progressed, the precise link between SQLE and ferroptosis in HCC remains ...
Xun Yang, Yidi Wu, Qingxin Zhang, Yunfei Zhou, Shuyuan Chang, Chunhui Zhang, Dabin Liu   +6 more
doaj   +1 more source

GRPR Drives Metastasis via CRABP2 and FNDC4 Pathways in Lung Adenocarcinoma

Cells
Metastasis is a leading cause of lung adenocarcinoma (LUAD)-related mortality and presents significant challenges for treatment. The gastrin-releasing peptide receptor (GRPR), a member of the G protein-coupled receptor (GPCR) family, has an unclear role ...
Dong-Gun Kim, Eun-Young Choi, Hye-Mi Ahn, Youn-Jae Kim   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

EGFR-family expression and implications for targeted radionuclide therapy

, 2008
Summary High expression in the primary tumor of receptors in the EGFR-family is most often also accompanied by a similar high expression in corresponding metastases.
Carlsson, Jörgen,
core