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Targeted Therapies in Melanoma [PDF]

Surgical Oncology Clinics of North America, 2015
Advances in understanding the biology of melanoma have provided great insights about the mechanisms of chemoresistance and its genetic heterogeneity in parallel with advances in drug design culminating in recent major treatment breakthroughs using small molecules inhibitors in metastatic melanoma (MM).
Stergios J, Moschos, Ramya, Pinnamaneni
openaire   +2 more sources

Targeted Therapy for Melanoma

, 2015
Vemurafenib and dabrafenib, two potent tyrosine kinase inhibitors (TKIs) of the BRAF(V600E) kinase, are highly effective in the treatment of a BRAF (V600) -mutant metastatic melanoma. These are selective type I inhibitors (functional against the active conformation of the kinase) of the RAF kinases, which are key players in the mitogen-activated ...
Wong, Deborah JL, Ribas, Antoni
openaire   +4 more sources

Tenascin-C Downregulates Wnt Inhibitor Dickkopf-1, Promoting Tumorigenesis in a Neuroendocrine Tumor Model

Cell Reports, 2013
The extracellular matrix molecule tenascin-C (TNC) is a major component of the cancer-specific matrix, and high TNC expression is linked to poor prognosis in several cancers.
Falk Saupe, Anja Schwenzer, Yundan Jia, Isabelle Gasser, Caroline Spenlé, Benoit Langlois, Martial Kammerer, Olivier Lefebvre, Ruslan Hlushchuk, Tristan Rupp, Marija Marko, Michael van der Heyden, Gérard Cremel, Christiane Arnold, Annick Klein, Patricia Simon-Assmann, Valentin Djonov, Agnès Neuville-Méchine, Irene Esposito, Julia Slotta-Huspenina, Klaus-Peter Janssen, Olivier de Wever, Gerhard Christofori, Thomas Hussenet, Gertraud Orend   +24 more
doaj   +1 more source

A Highlight of the Mechanisms of Immune Checkpoint Blocker Resistance

Frontiers in Cell and Developmental Biology, 2020
In recent years, as our understanding of tumor immunology is continuously improved, immunotherapy has come to the center stage of cancer therapy and is deemed as the most promising approach for cancer control.
Qian Huang, Yanna Lei, Xiaoying Li, Fukun Guo, Ming Liu   +4 more
doaj   +1 more source

Low extracellular pH protects cancer cells from ammonia toxicity

Cell Death Discovery
Ammonia is a natural waste product of cellular metabolism which, through its lysosomotropic ability, can have detrimental effects on various cellular functions.
Maria Dravecka, Ingvild Mikkola, Terje Johansen, Ole Morten Seternes, Jakob Mejlvang   +4 more
doaj   +1 more source

The LEDGIN GS-9822 inhibits HIV-2 infection and enhances HIV-2 latency

Microbiology Spectrum
HIV integration is targeted toward active transcription units through the interaction of HIV integrase with the cellular co-factor LEDGF/p75. LEDGINs, small molecule inhibitors of this interaction, reduce HIV-1 integration and retarget residual ...
Anne Bruggemans, Gerlinde Vansant, Eline Pellaers, Paulien Van de Velde, Frauke Christ, Zeger Debyser   +5 more
doaj   +1 more source

HOX and PBX gene dysregulation as a therapeutic target in glioblastoma multiforme

BMC Cancer, 2022
Background Glioblastoma multiforme (GBM) is the most common high-grade malignant brain tumour in adults and arises from the glial cells in the brain. The prognosis of treated GBM remains very poor with 5-year survival rates of 5%, a figure which has not ...
Einthavy Arunachalam, William Rogers, Guy R. Simpson, Carla Möller-Levet, Gemma Bolton, Mohammed Ismael, Christopher Smith, Karl Keegen, Izhar Bagwan, Tim Brend, Susan C. Short, Bangxing Hong, Yoshihiro Otani, Balveen Kaur, Nicola Annels, Richard Morgan, Hardev Pandha   +16 more
doaj   +1 more source

Exploration of Euscaphic Acid on Non-Hodgkin Lymphoma Based on Network Pharmacology, Molecular Docking and Cell Experiment

Natural Product Communications
Background: Euscaphic acid (EA) has been found that can inhibit the proliferation of various types of tumor cells, including non-Hodgkin's lymphoma (NHL) cells. However, the underlying mechanism of EA in the treatment of NHL is unclear.
Guangru Li, Chunyuan Liang, Yan Liu, Yueyuan Pan, Zhiyuan Li, Guocai Wu, Ruiting Wen   +6 more
doaj   +1 more source

Multi-cohort analysis and experimental study on the function of squalene epoxidase as a ferroptosis inhibitor in HCC

BMC Cancer
Squalene epoxidase (SQLE) drives hepatocellular carcinoma (HCC) development via increased hepatic oxidative stress, a hallmark of ferroptosis. Although investigations have progressed, the precise link between SQLE and ferroptosis in HCC remains ...
Xun Yang, Yidi Wu, Qingxin Zhang, Yunfei Zhou, Shuyuan Chang, Chunhui Zhang, Dabin Liu   +6 more
doaj   +1 more source

Surgery after induction targeted therapy and immunotherapy for lung cancer

, 2021
: Simple Summary For patients with locally advanced non-small cell lung cancer (NSCLC) or positive N1 nodes, multimodality treatment is indicated. However, the optimal management of patients presenting with ipsilateral positive mediastinal nodes (N2 ...
Toon Allaeys, Lawek Berzenji, van Schil, Paul, Berzenji, Lawek, Paul E. Van Schil, Allaeys, Toon   +5 more
core   +1 more source