Translational Oncology, 2021 Across many cancer types in adults, upregulation of the nuclear-to-cytoplasmic transport protein Exportin-1 (XPO1) correlates with poor outcome and responsiveness to selinexor, an FDA-approved XPO1 inhibitor.
Basia Galinski +9 more
doaj +1 more source
A Thermodynamic-Based Interpretation of Protein Expression Heterogeneity in Different Glioblastoma Multiforme Tumors Identifies Tumor-Specific Unbalanced Processes [PDF]
, 2016 We describe a thermodynamic-motivated, information theoretic analysis of proteomic data collected from a series of 8 glioblastoma multiforme (GBM) tumors. GBMs are considered here as prototypes of heterogeneous cancers.
Heath, James R. +4 more
core +3 more sources
Protein biomarkers for response to XPO1 inhibition in hematologic malignancies
Journal of Cellular and Molecular Medicine, 2022 AbstractXPO1 (Exportin-1) is the nuclear export protein responsible for the normal shuttling of several proteins and RNA species between the nucleocytoplasmic compartment of eukaryotic cells. XPO1 recognizes the nuclear export signal (NES) of its cargo proteins to facilitate its export.
Tulasigeri M. Totiger +9 more
openaire +2 more sources
NRG1/ERBB3 Pathway Activation Induces Acquired Resistance to XPO1 Inhibitors [PDF]
Molecular Cancer Therapeutics, 2020 Abstract XPO1 inhibitors have shown promise in cancer treatment, but mechanisms of resistance to these drugs are not well understood. In this study, we established selective inhibitors of nuclear export (SINE)-resistant ovarian cancer cell lines from in vivo mouse tumors and determined the mechanisms of adaptive XPO1 inhibitor ...
Takahito M. Miyake +10 more
openaire +2 more sources
Simultaneous targeting of XPO1 and BCL2 as an effective treatment strategy for double-hit lymphoma
Journal of Hematology & Oncology, 2019 Double-hit lymphoma (DHL) is among the most aggressive and chemoresistant lymphoma subtypes. DHLs carry genomic abnormalities in MYC, BCL2, and/or BCL6 oncogenes. Due to the simultaneous overexpression of these driver oncogenes, DHLs are highly resistant
Yuanhui Liu +4 more
doaj +1 more source
Nuclear DDX3 expression predicts poor outcome in colorectal and breast cancer [PDF]
, 2017 Purpose: DEAD box protein 3 (DDX3) is an RNA helicase with oncogenic properties that shuttles between the cytoplasm and nucleus. The majority of DDX3 is found in the cytoplasm, but a subset of tumors has distinct nuclear DDX3 localization of yet unknown ...
Bol, Guus M. +10 more
core +2 more sources
The T-loop extension of the tomato protein Kinase AvrPto-dependent Pto-interacting Protein 3 (Adi3) directs nuclear localization for suppression of plant cell death [PDF]
, 2010 In tomato (Solanum lycopersicum), resistance to Pseudomonas syringae pv. tomatois elicited by the interaction of the host Pto kinase with the pathogen effector protein AvrPto, which leads to various immune responses including localized cell death termed ...
María J. Ek-Ramos +77 more
core +1 more source
Nuclear Export in Non-Hodgkin Lymphoma and Implications for Targeted XPO1 Inhibitors
Biomolecules, 2023 Exportin-1 (XPO1) is a key player in the nuclear export pathway and is overexpressed in almost all cancers. This is especially relevant for non-Hodgkin lymphoma (NHL), where high XPO1 expression is associated with poor prognosis due to its oncogenic role
Kyla L. Trkulja +3 more
doaj +1 more source
Genomic analyses of microdissected Hodgkin and Reed-Sternberg cells: mutations in epigenetic regulators and p53 are frequent in refractory classic Hodgkin lymphoma [PDF]
, 2019 This work was supported by grants from the Plan Nacional de I + D + I cofinanced by the ISCIII-Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER), PI12/1832, the Spanish Association for Cancer Research (AECC), and ...
Astudillo, Aurora +11 more
core +2 more sources
Alternative splicing enriched cDNA libraries identify breast cancer-associated transcripts [PDF]
, 2010 Background: Alternative splicing (AS) is a central mechanism in the generation of genomic complexity and is a major contributor to transcriptome and proteome diversity.
Elisa N Ferreira +6 more
core +2 more sources