Results 51 to 60 of about 7,047 (156)
HematologyObjectives Aberrant nucleocytoplasmic transport mediated by Exportin 1 (XPO1) contributes to leukemogenesis, yet the molecular basis underlying the limited efficacy of the XPO1 inhibitor Selinexor in acute myeloid leukemia (AML) remains unclear.
Chunli Xu +5 more
doaj +1 more source
MiR‐483‐3p improves learning and memory abilities via XPO1 in Alzheimer's disease
Brain and Behavior, 2022 Introduction Alzheimer's disease (AD), a common form of dementia, has been reported to influence 27 million individuals globally. Several risk factors including oxidative stress, gut microbiota imbalance, and cognitive activity are reported to be closely
Gang Luo, Xiaoyan Wang, Changya Liu
doaj +1 more source
Health Science Reports, Volume 9, Issue 10, October 2026.ABSTRACT Background Exosomes are naturally secreted nanovesicles with high biocompatibility, low immunogenicity, and the ability to traverse biological barriers, making them attractive theragnostic carriers. When engineered to present tumor‐specific antibodies and to deliver antibody‐drug conjugates (ADCs), they may enhance selective targeting of ...
Subham Sarkar +5 more
wiley +1 more source
Expression of exportin 1 (XPO1/CRM1) in pancreatic adenocarcinoma.
, 2017 327 Background: Exportin 1 (XPO1/CRM1) is a nuclear export chaperone that mediates the nuclear export of several proteins that are essential to growth regulation and tumor suppression.
David M Saulino +3 more
core +1 more source
Identifying Drug-Target Selectivity of Small-Molecule CRM1/XPO1 Inhibitors by CRISPR/Cas9 Genome Editing [PDF]
, 2015 SummaryValidation of drug-target interaction is essential in drug discovery and development. The ultimate proof for drug-target validation requires the introduction of mutations that confer resistance in cells, an approach that is not straightforward in ...
Crochiere, Marsha +9 more
core +1 more source
MedComm, Volume 7, Issue 10, October 2026.BTK inhibitors suppress malignant B‐cell signaling while simultaneously reshaping immune regulation through effects on T cells and the tumor microenvironment. These mechanisms support combination immunotherapy strategies and also underlie the expanding application of BTK inhibitors in solid tumors, autoimmune and inflammatory diseases.
Miao Sun, Dengju Li, Jia Wei
wiley +1 more source
To Treat or Not to Treat: Navigating Early‐Stage CLL in the Era of Targeted Therapy
European Journal of Haematology, Volume 117, Issue 4, Page 750-766, October 2026.ABSTRACT Chronic lymphocytic leukemia (CLL) is most frequently diagnosed at early, asymptomatic stages (Rai 0/Binet A), in which a watch‐and‐wait strategy remains the standard of care, based on historical trials demonstrating no overall survival benefit from early treatment.
Enrica Antonia Martino +16 more
wiley +1 more source
Prognostic impact of XPO1 mutations in metastatic non-small cell lung cancer (NSCLC)
, 2021 e20533 Background: Nuclear protein transport is essential in guiding the organized traffic of important proteins and RNAs between the nucleus and cytoplasm of the cell. Export of proteins from the nucleus is exclusively regulated by Exportin 1(XPO1).
Raez, Luis E. +19 more
core +1 more source
Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger +7 more
wiley +1 more source
Ded1ΔC binds to the exterior of the Xpo1 toroid.
, 2015 (a) Raw scattering data for a purified Xpo1:Ran[GTP]Q71L:Ded1ΔC complex. (b) Gunier plot for the raw data in (a). The black squares indicate the linear Gunier region. (c) P(r) curve for the raw data in (a).
Gregory D. Bowman (762237) +1 more
core +1 more source