Results 71 to 80 of about 5,881 (166)

Directed Evolution Improves the Catalytic Efficiency of APEX2‐Mediated Proximity‐Dependent RNA Labeling

Advanced Science, Volume 13, Issue 32, 9 June 2026.
ABSTRACT Engineered ascorbate peroxidase APEX2 has been widely used for spatially restricted profiling of subcellular biomolecules, but its catalytic efficiency toward newly developed probes such as biotin‐aniline (Btn‐An) remains suboptimal. To overcome this limitation, we performed yeast surface display‐based directed evolution to enhance APEX2 ...
Gang Wang, Yi Li, Peiyuan Meng, Peng Zou
wiley   +1 more source

Specific inhibition of the nuclear exporter exportin-1 attenuates kidney cancer growth.

PLoS ONE, 2014
PurposeDespite the advent of FDA-approved therapeutics to a limited number of available targets (kinases and mTOR), PFS of kidney cancer (RCC) has been extended only one to two years due to the development of drug resistance.
Hiromi I Wettersten, Yosef Landesman, Sharon Friedlander, Sharon Shacham, Michael Kauffman, Robert H Weiss   +5 more
doaj   +1 more source

XPO1 Inhibition enhances sensitivity to platinum-based chemotherapy in germinal-center B-cell-like-DLBCL cells

Hematology
Purpose: Platinum-based chemotherapy is considered as salvage therapy to relapsed/refractory diffuse large B-cell lymphoma (DLBCL) patients. However, treatment failure due to drug resistance occurs in some patients, particularly those with Exportin 1 ...
Qiongqiong Su, Xiaolei Wei, Yongqiang Wei, Ru Feng   +3 more
doaj   +1 more source

The roles of p53 and XPO1 on colorectal cancer progression in Yemeni patients

Journal of Gastrointestinal Oncology, 2019
The colorectal cancer (CRC) tumorigenesis is driving by genetic alterations leading to changes in protein expression such as p53. The p53 is frequently expressed in CRC and its association with clinicopathological features is still controversial. Moreover, accumulated evidence suggests that both p53 and nuclear exporter protein, exportin 1 (XPO1), are ...
Mohammed, Aladhraei, Eman, Al-Salami, Naravat, Poungvarin, Prasit, Suwannalert   +3 more
openaire   +2 more sources

XPO1 blockade with KPT-330 promotes apoptosis in cutaneous T-cell lymphoma by activating the p53–p21 and p27 pathways

Scientific Reports
Dysregulated nuclear-cytoplasmic trafficking has been shown to play a role in oncogenesis in several types of solid tumors and hematological malignancies. Exportin 1 (XPO1) is responsible for the nuclear export of several proteins and RNA species, mainly
Nitin Chakravarti, Amy Boles, Rachel Burzinski, Paola Sindaco, Colleen Isabelle, Kathleen McConnell, Anjali Mishra, Pierluigi Porcu   +7 more
doaj   +1 more source

Effect of Exportin 1/XPO1 Nuclear Export Pathway Inhibition on Coronavirus Replication

Viruses
The nucleocytoplasmic transport of proteins using XPO1 (exportin 1) plays a vital role in cell proliferation and survival. Many viruses also exploit this pathway to promote infection and replication.
Masmudur M. Rahman, Bereket Estifanos, Honor L. Glenn, Ami D. Gutierrez-Jensen, Karen Kibler, Yize Li, Bertram Jacobs, Grant McFadden, Brenda G. Hogue   +8 more
doaj   +1 more source

Novel small molecule XPO1/CRM1 inhibitors induce nuclear accumulation of TP53, phosphorylated MAPK and apoptosis in human melanoma cells.

PLoS ONE, 2014
XPO1/CRM1 is a key nuclear exporter protein that mediates translocation of numerous cellular regulatory proteins. We investigated whether XPO1 is a potential therapeutic target in melanoma using novel selective inhibitors of nuclear export (SINE).
Jennifer Yang, Matthew A Bill, Gregory S Young, Krista La Perle, Yosef Landesman, Sharon Shacham, Michael Kauffman, William Senapedis, Trinayan Kashyap, Jean-Richard Saint-Martin, Kari Kendra, Gregory B Lesinski   +11 more
doaj   +1 more source

Rare Case of de Novo 2p15 Microdeletion Syndrome with Deletion Covering XPO1 and USP34 Genes Diagnosed in a Child – A Case Report

The Application of Clinical Genetics
Gabriela Ręka, Katarzyna Wojciechowska, Monika Lejman Independent Laboratory of Genetic Diagnostics of the Second Chair of Pediatrics, Medical University of Lublin, Lublin, PolandCorrespondence: Gabriela Ręka, Independent Laboratory of ...
Ręka G, Wojciechowska K, Lejman M
doaj  

Human Exportin-1 is a Target for Combined Therapy of HIV and AIDS Related Lymphoma

EBioMedicine, 2015
Infection with HIV ultimately leads to advanced immunodeficiency resulting in an increased incidence of cancer. For example primary effusion lymphoma (PEL) is an aggressive non-Hodgkin lymphoma with very poor prognosis that typically affects HIV infected
Eline Boons, Els Vanstreels, Maarten Jacquemyn, Tatiane C. Nogueira, Jasper E. Neggers, Thomas Vercruysse, Joost van den Oord, Sharon Tamir, Sharon Shacham, Yosef Landesman, Robert Snoeck, Christophe Pannecouque, Graciela Andrei, Dirk Daelemans   +13 more
doaj   +1 more source

The effect of aberrant expression and genetic polymorphisms of Rad21 on cervical cancer biology

Cancer Medicine, 2018
The therapeutic challenge of advanced, recurrent, and refractory cervical cancer (CC) needs to develop new molecularly targeted drugs. Rad21 is an important regulatory gene that maintains the correct dissociation of sister chromatids during cell mitosis.
Li Xia, Minjie Wang, Hongying Li, Xiangjing Tang, Fei Chen, Jinquan Cui   +5 more
doaj   +1 more source