Results 71 to 80 of about 7,047 (156)

Biochemical and predicted ligand-target interactions with XPO1.

, 2023
A,B. “Click-chemistry” pull-down assay demonstrating covalent binding of an alkynated 4OI probe (4-OI-alk) to XPO1 (A) and KEAP1 (B) in Calu-3 cells. At the indicated time points after addition of the probe to the cells, proteins complexed with the probe
Mahmoud Shehata (9574695), David Olagnier (205583), Andreas Pavlou (15272395), Ulrich Martin (62121), Stephan Pleschka (85578), Fabio Begnini (4795374), Anna K. H. Hirsch (7491110), Naziia Kurmasheva (11575748), Sylvia Merkert (16558010), Ruth Olmer (3744291), Thomas B. Poulsen (2478502), Anders E. Kiib (16558004), Chutao Chen (16558007), Fakhar H. Waqas (16557998), Walid A. M. Elgaher (8355894), Antoine Lacour (16558001), Frank Pessler (52000), Julia Dahlmann (4919113)   +17 more
core   +1 more source

Identifying Novel Interaction Partners for Importin-8 and XPO1/CRM1 [PDF]

The Karyopherin-β or Kap protein family consists of importins and exportins that mediate the bulk of macromolecular nucleocytoplasmic transport in eukaryotic cells. The first part of my project focuses on the drug-induced degradation of the Exportin 1 or
Hudman-Wing, Casey Elizabeth
core   +1 more source

Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma

The FEBS Journal, Volume 293, Issue 17, Page 5121-5139, September 2026.
IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture, Devi Nandana, Karthik Ramasamy, Anjan Thakurta   +3 more
wiley   +1 more source

Xpo1 and Ran[GTP] reduce the ATPase activity of Ded1 in an NES-dependent manner.

, 2015
(a) The RNA-dependent ATPase activity of Ded1 is reduced in the presence of Xpo1/Ran[GTP]. The rates of ATP hydrolysis for either wildtype (+) or an ATPase-dead variant (Ded1D306N) of Ded1 (500 nM) in the presence or absence of yeast whole-cell RNA (320 ...
Gregory D. Bowman (762237), Glenn Hauk (762236)   +1 more
core   +1 more source

Detection and prognostic value of recurrent exportin 1 mutations in tumor and cell-free circulating DNA of patients with classical Hodgkin lymphoma

Haematologica, 2016
Classical Hodgkin lymphoma is one of the most common lymphomas and shares clinical and genetic features with primary mediastinal B-cell lymphoma. In this retrospective study, we analyzed the recurrent hotspot mutation of the exportin 1 (XPO1, p.E571K ...
Vincent Camus, Aspasia Stamatoullas, Sylvain Mareschal, Pierre-Julien Viailly, Nasrin Sarafan-Vasseur, Elodie Bohers, Sydney Dubois, Jean Michel Picquenot, Philippe Ruminy, Catherine Maingonnat, Philippe Bertrand, Marie Cornic, Valérie Tallon-Simon, Stéphanie Becker, Liana Veresezan, Thierry Frebourg, Pierre Vera, Christian Bastard, Hervé Tilly, Fabrice Jardin   +19 more
doaj   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, Volume 13, Issue 43, 3 August 2026.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Drug Resistance in Multiple Myeloma: Tumor‐Intrinsic Mechanisms and the Bone Marrow Microenvironment

Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT Multiple myeloma (MM) is a malignant plasma cell disorder, and despite substantial improvements in prognosis achieved through chemotherapy, immunotherapy, and autologous stem cell transplantation, most patients ultimately develop relapsed or refractory disease. Drug resistance (DR) is increasingly recognized as a dynamically evolving ecosystem
Yixuan Chen, Wenming Huang, Mingxuan Tang, Xiaotao Wang   +3 more
wiley   +1 more source

Specific inhibition of the nuclear exporter exportin-1 attenuates kidney cancer growth.

PLoS ONE, 2014
PurposeDespite the advent of FDA-approved therapeutics to a limited number of available targets (kinases and mTOR), PFS of kidney cancer (RCC) has been extended only one to two years due to the development of drug resistance.
Hiromi I Wettersten, Yosef Landesman, Sharon Friedlander, Sharon Shacham, Michael Kauffman, Robert H Weiss   +5 more
doaj   +1 more source

XPO1 Inhibition enhances sensitivity to platinum-based chemotherapy in germinal-center B-cell-like-DLBCL cells

Hematology
Purpose: Platinum-based chemotherapy is considered as salvage therapy to relapsed/refractory diffuse large B-cell lymphoma (DLBCL) patients. However, treatment failure due to drug resistance occurs in some patients, particularly those with Exportin 1 ...
Qiongqiong Su, Xiaolei Wei, Yongqiang Wei, Ru Feng   +3 more
doaj   +1 more source

XPO1 blockade with KPT-330 promotes apoptosis in cutaneous T-cell lymphoma by activating the p53–p21 and p27 pathways

Scientific Reports
Dysregulated nuclear-cytoplasmic trafficking has been shown to play a role in oncogenesis in several types of solid tumors and hematological malignancies. Exportin 1 (XPO1) is responsible for the nuclear export of several proteins and RNA species, mainly
Nitin Chakravarti, Amy Boles, Rachel Burzinski, Paola Sindaco, Colleen Isabelle, Kathleen McConnell, Anjali Mishra, Pierluigi Porcu   +7 more
doaj   +1 more source