Results 71 to 80 of about 9,702 (191)
NMD3 regulates both mRNA and rRNA nuclear export in African trypanosomes via an XPOI-linked pathway [PDF]
, 2017 Trypanosomes mostly regulate gene expression through post-transcriptional mechanisms, particularly mRNA stability. However, much mRNA degradation is cytoplasmic such that mRNA nuclear export must represent an important level of regulation. Ribosomal RNAs
Bühlmann, Melanie +7 more
core
Stress-induced nuclear accumulation is dispensable for Hog1-dependent gene expression and virulence in a fungal pathogen [PDF]
, 2017 The authors thank E. Veal for intellectual input. This work was funded by the UK Biotechnology and Biological Research Council [J.Q. BB/K016393/1; A.J.P.B.
Brown, Alistair J P +4 more
core +2 more sources
2026 Update on the Management of Diffuse Large B‐Cell Lymphoma
American Journal of Hematology, Volume 101, Issue 4, Page 832-863, April 2026.ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) is the most common type of NHL in the Western Hemisphere. It comprises a heterogenous group of lymphomas, with different biology and clinical prognoses. R‐CHP remains the backbone of therapy, and frontline therapeutic options in fit patients are pola‐R‐CHP and R‐CHOP, whereas elderly or frail/unfit ...
Elise A. Chong +2 more
wiley +1 more source
HematologyObjectives Aberrant nucleocytoplasmic transport mediated by Exportin 1 (XPO1) contributes to leukemogenesis, yet the molecular basis underlying the limited efficacy of the XPO1 inhibitor Selinexor in acute myeloid leukemia (AML) remains unclear.
Chunli Xu +5 more
doaj +1 more source
Translational Oncology, 2021 Neuroblastoma (NBL) is an embryonal malignancy of childhood with poor outcomes for patient with high-risk disease. Multimodal treatment approaches have improved outcomes but at the cost of significant toxicity, and there is no durable therapeutic ...
Nilay Shah
doaj +1 more source
The DEAD-box helicase Ded1 from yeast is an mRNP cap-associated protein that shuttles between the cytoplasm and nucleus [PDF]
, 2014 International audienceThe DEAD-box helicase Ded1 is an essential yeast protein that is closely related to mammalian DDX3 and to other DEAD-box proteins involved in developmental and cell cycle regulation. Ded1 is considered to be a translation-initiation
Adam, Céline +5 more
core +2 more sources
Drugs and Drug Candidates, 2023 Exportin 1 (XPO1) is a crucial molecule of nucleocytoplasmic transport. Among others, it exports molecules important for oncogenesis from the nucleus to the cytoplasm. The expression of XPO1 is increased in numerous malignancies, which contributes to the
Kajetan Karaszewski +1 more
doaj +1 more source
Nuclear versus cytosolic activity of the yeast Hog1 MAP kinase in response to osmotic and tunicamycin-induced ER stress [PDF]
, 2015 © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. We examined the physiological significance of the nuclear versus cytosolic localization of the MAPK Hog1p in the ability of yeast cells to cope with ...
García Marqués, Sara +2 more
core +1 more source
Health Science Reports, Volume 9, Issue 4, April 2026.ABSTRACT Background and Aims Non‐Hodgkin lymphoma (NHL) is the most prevalent hematological malignancy worldwide and accounts for approximately 3% of all cancer cases and fatalities. Next‐generation sequencing (NGS) has advanced molecular diagnosis and targeted treatment in developed countries.
Mohammadreza Saeidnia +8 more
wiley +1 more source
Dual Inhibition of Bcl-2/Bcl-xL and XPO1 is synthetically lethal in glioblastoma model systems
Scientific Reports, 2018 XPO1 has recently emerged as a viable treatment target for solid malignancies, including glioblastoma (GBM), the most common primary malignant brain tumor in adults.
Enyuan Shang +7 more
doaj +1 more source