Results 81 to 90 of about 7,047 (156)

Effect of Exportin 1/XPO1 Nuclear Export Pathway Inhibition on Coronavirus Replication

Viruses
The nucleocytoplasmic transport of proteins using XPO1 (exportin 1) plays a vital role in cell proliferation and survival. Many viruses also exploit this pathway to promote infection and replication.
Masmudur M. Rahman, Bereket Estifanos, Honor L. Glenn, Ami D. Gutierrez-Jensen, Karen Kibler, Yize Li, Bertram Jacobs, Grant McFadden, Brenda G. Hogue   +8 more
doaj   +1 more source

Rare Case of de Novo 2p15 Microdeletion Syndrome with Deletion Covering XPO1 and USP34 Genes Diagnosed in a Child – A Case Report

The Application of Clinical Genetics
Gabriela Ręka, Katarzyna Wojciechowska, Monika Lejman Independent Laboratory of Genetic Diagnostics of the Second Chair of Pediatrics, Medical University of Lublin, Lublin, PolandCorrespondence: Gabriela Ręka, Independent Laboratory of ...
Ręka G, Wojciechowska K, Lejman M
doaj  

Novel small molecule XPO1/CRM1 inhibitors induce nuclear accumulation of TP53, phosphorylated MAPK and apoptosis in human melanoma cells.

PLoS ONE, 2014
XPO1/CRM1 is a key nuclear exporter protein that mediates translocation of numerous cellular regulatory proteins. We investigated whether XPO1 is a potential therapeutic target in melanoma using novel selective inhibitors of nuclear export (SINE).
Jennifer Yang, Matthew A Bill, Gregory S Young, Krista La Perle, Yosef Landesman, Sharon Shacham, Michael Kauffman, William Senapedis, Trinayan Kashyap, Jean-Richard Saint-Martin, Kari Kendra, Gregory B Lesinski   +11 more
doaj   +1 more source

XPO1 inhibition by KPT-185 in MCL.

, 2015
XPO1 inhibition by KPT-185 impairs ribosomal biogenesis, in addition to blocking p53 degradation and inhibiting CyclinD1, c-Myc, and PIM1 translation in MCL. Please refer to the discussion for further details.
Richard Eric Davis (792122), Michael Andreeff (31491), Hiromichi Matsushita (405560), Kazumasa Sekihara (485106), Michael Kauffman (519875), Jo Ishizawa (792124), Takashi Miida (427420), Saiko Kazuno (495066), Sharon Shacham (519876), Zhiqiang Wang (48987), Yoko Tabe (427415), Shinichi Yamamoto (792121), Takashi Ueno (411589), Tsutomu Fujimura (495062), Kensuke Kojima (517560), Wencai Ma (792123)   +15 more
core   +1 more source

Abstracts of 14th International Symposium on Hodgkin Lymphoma

HemaSphere, Volume 10, Issue S2, October 2026.
wiley   +1 more source

Abstract 1938: Exportin-1 (XPO1) is a novel therapeutic biomarker for patients with neuroblastoma

, 2017
Background: Half of patients with high-risk neuroblastoma succumb to disease, yet these patients with inferior outcome cannot be identified at diagnosis despite contemporary risk stratification that integrates MYCN copy number status, tumor histology ...
Yosef Landesman, Basia Galinski, Michelle Ewart, Daniel Weiser, Marcus Luxemburg   +4 more
core   +1 more source

The effect of aberrant expression and genetic polymorphisms of Rad21 on cervical cancer biology

Cancer Medicine, 2018
The therapeutic challenge of advanced, recurrent, and refractory cervical cancer (CC) needs to develop new molecularly targeted drugs. Rad21 is an important regulatory gene that maintains the correct dissociation of sister chromatids during cell mitosis.
Li Xia, Minjie Wang, Hongying Li, Xiangjing Tang, Fei Chen, Jinquan Cui   +5 more
doaj   +1 more source

Nuclear to Cytoplasmic Transport Is a Druggable Dependency in HDAC7‐driven Small Cell Lung Cancer

Advanced Science
Immunotherapy has gained approval for use in small cell lung cancer (SCLC), yet only a subset of patients (10–20%) experience meaningful benefits, underscoring the urgent need for more effective therapeutic approaches.
Tingting Qin, Jingya Wang, Jian Wang, Qingwu Du, Liuchun Wang, Hailin Liu, Wenting Liu, Xueyang Li, Yantao Jiang, Qi Xu, Junjie Yu, Huiyan Liu, Ting Wang, Mengjie Li, Dingzhi Huang   +14 more
doaj   +1 more source

XPO1抑制剂KPT-8602对U937细胞增殖和凋亡的影响

Zhongshan Daxue xuebao. Yixue kexue ban, 2019
目的】探讨核输出蛋白（XPO1）选择性抑制剂KPT-8602对人组织细胞淋巴瘤细胞系U937细胞增殖、周期、凋亡的影响及其可能的机制研究。【方法】以U937细胞为研究对象，给予不同浓度的KPT-8602处理细胞后，CCK-8法检测细胞活力；流式细胞术检测细胞周期及凋亡；Westernblot法检测XPO1、p-AKT、AKT、CleavedCaspase-3、p21的表达情况；荧光显微镜观察XPO1的亚细胞定位。【结果】CCK-8结果显示KPT-8602可抑制U937细胞的活力，在一定范围内具有剂量 ...
肖晓慧, 李益清, 黄克智, 谢双锋, 肖洁, 马丽萍, 尹松梅, 聂大年   +7 more
doaj  

The nuclear export receptor Xpo1 is involved in the spindle formation in the baker's yeast Saccharomyces cerevisiae

, 2008
Zusammenfassung 6 Abstract 7 1\. Einleitung 8 1.1 Kerntransport 8 1.1.1 Bedeutung des Kerntransports 8 1.1.2 Die lösliche Phase: Transport-Rezeptoren 8 1.1.3 Die stationäre Phase: Nukleoporine 13 1.1.4 Ran-Gradient und Energiebedarf 14 1.1.5 Import- und ...
Neuber, Anja
core   +1 more source