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XPO1/Exportin-1 in Acute Myelogenous Leukemia; Biology and Therapeutic Targeting
BiomoleculesExportin 1 is responsible for the export of hundreds of proteins, several RNA species and ribosomal components from the nucleus to the cytoplasm. Several transported proteins are important for regulation of cell proliferation and survival both in normal and malignant cells.
Øystein Bruserud +3 more
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Nuclear to Cytoplasmic Transport Is a Druggable Dependency in HDAC7‐driven Small Cell Lung Cancer
Advanced ScienceImmunotherapy has gained approval for use in small cell lung cancer (SCLC), yet only a subset of patients (10–20%) experience meaningful benefits, underscoring the urgent need for more effective therapeutic approaches.
Tingting Qin +14 more
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The nuclear export receptor CRM1/XPO1 and its diverse cargoes
Trends in Biochemical SciencesCRM1 (Exportin 1, XPO1), the best-characterized nuclear export receptor, exports hundreds of proteins and various RNA species. Its broad cargo repertoire necessitates versatile binding modes for diverse interaction partners, including nuclear export signal/sequence (NES)-containing cargoes, the GTPase Ran, nucleoporins that line nuclear pore complexes,
Ralph H. Kehlenbach, Yuh Min Chook
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NucleusNucleocytoplasmic transport is essential for cellular homeostasis and is frequently exploited by viruses during infection. Although dengue virus (DENV) non-structural protein 3 (NS3) undergoes nuclear trafficking, the role of nuclear export pathways in ...
Selvin Noé Palacios-Rápalo +7 more
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XPO1抑制剂KPT-8602对U937细胞增殖和凋亡的影响
Zhongshan Daxue xuebao. Yixue kexue ban, 2019 目的】探讨核输出蛋白（XPO1）选择性抑制剂KPT-8602对人组织细胞淋巴瘤细胞系U937细胞增殖、周期、凋亡的影响及其可能的机制研究。【方法】以U937细胞为研究对象，给予不同浓度的KPT-8602处理细胞后，CCK-8法检测细胞活力；流式细胞术检测细胞周期及凋亡；Westernblot法检测XPO1、p-AKT、AKT、CleavedCaspase-3、p21的表达情况；荧光显微镜观察XPO1的亚细胞定位。【结果】CCK-8结果显示KPT-8602可抑制U937细胞的活力，在一定范围内具有剂量 ...
肖晓慧 +7 more
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Communications BiologyWilms tumor (WT) is the most common renal malignancy of childhood. Despite improvements in the overall survival, relapse occurs in ~15% of patients with favorable histology WT (FHWT). Half of these patients will succumb to their disease.
Karuna Mittal +37 more
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