Results 91 to 100 of about 7,047 (156)

The mechanism of XPO1 export, and its expression in human skin samples and melanoma cell lines.

, 2014
A. Mechanistic explanation of XPO1 mediated nuclear export pathway adapted from Kau 2013 [10]. B. A human melanoma tissue microarray was stained for XPO1 and quantified. The core includes 56 cases of primary melanoma, 20 cases of metastatic melanoma, and
Jennifer Yang (239071), Trinayan Kashyap (603697), Sharon Shacham (519876), Jean-Richard Saint-Martin (519873), Gregory B. Lesinski (143939), Krista La Perle (603694), Matthew A. Bill (143903), Kari Kendra (603698), Yosef Landesman (603695), William Senapedis (603696), Michael Kauffman (519875), Gregory S. Young (143925)   +11 more
core   +1 more source

The nuclear export protein XPO1 provides a peptide ligand for natural killer cells

XPO1 (Exportin-1/CRM1) is a nuclear export protein that is frequently overexpressed in cancer and functions as a driver of oncogenesis. Currently small molecules that target XPO1 are being used in the clinic as anticancer agents.
Mansour, Salah, Das, Jayajit, Purcell, Anthony W., Blunt, Matthew D., Mbiribindi, Berenice, Fulton, Rebecca, Espana-Serrano, Laura, Khakoo, Sophie M.S., Khakoo, Salim I., Fisher, Hayden, Graham, Lara V., Ayala, Rochelle, Essex, Jonathan W., Bastidas-Legarda, Leidy, Burns, Daniel, Khan, Sajida, Schittenhelm, Ralf B.   +16 more
core   +1 more source

Investigation into the immunomodulatory activity of XPO1 inhibitors

Nuclear export is an important process for regulating transcription and translation by spatial distribution of transcription factors, RNA and signalling components.
Fisher, Jack Graham
core   +1 more source

Targeting Nuclear Exporter Protein XPO1/CRM1 in Gastric Cancer

, 2019
Gastric cancer remains an unmet clinical problem in urgent need of newer and effective treatments. Here we show that the nuclear export protein, Exportin 1 (XPO1, chromosome region maintenance 1 or CRM1), is a promising molecular target in gastric cancer.
Husain Y. Khan, Rafic Beydoun, William Senapedis, Steve Kim, Zaid Mahdi, Philip A. Philip, Rachel Sexton, Anteneh Tesfaye, Erkan Baloglu, Yosef Landesman, Asfar S. Azmi, Rahman Chaudhury, Amro Aboukameel   +12 more
core   +1 more source

Discovery, Validation and Mechanistic Study of XPO1 Inhibition in the Treatment of Triple-Negative Breast Cancer

Background/Objectives: Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer with limited treatment options. The nuclear export protein XPO1 has emerged as a potential therapeutic target in cancer, but its role in TNBC has not been ...
R. Stephanie Huang, Robert F. Gruener, Adam M. Lee, Amy L. Paulson   +3 more
core   +1 more source

Investıgatıon of Notch1 and Xpo1 gene varıatıons ın chronıc lymphocytıc leukemıa

, 2019
Kronik Lenfositik Lösemi (KLL), yetişkinlerde en sık görülen lösemi tipidir. KLL’nin nedeni hala kesin olarak bilinmemektedir. NOTCH1 geninde NM_017617.5:c.7541_7542delCT; p.P2514Argfs varyasyonu ve XPO1 geninde NM_0033400.3:c.1711G>A varyasyonu KLL ...
Tunalı Özen, Elif
core   +1 more source

Cellular modifiers of TDP-43 phase transition and cytoplasmic aggregation. [PDF]

Elife
Chin N, Zhang Q, Zou J, Cheng KC, Zheng W, Ye Y.   +5 more
europepmc   +1 more source

XPO1: From basic research to clinical treatment (Review). [PDF]

Oncol Rep
Yang C, Zhu J, Zheng X, Hou X, Zhao J, Pan Y, Tang Y.   +6 more
europepmc   +1 more source

KPT-330-mediated XPO1 inhibition impairs homologous recombination and enhances radiosensitivity in extranodal NK/T-cell lymphoma. [PDF]

Br J Cancer
Zhou H, Liu Q, Ren K, Luo Q, Yang C, Fang T, Chen X, Zou L.   +7 more
europepmc   +1 more source

IFI208, an interferon-stimulated gene, promotes host antiviral responses through liquid-liquid phase separation of MDA5. [PDF]

Nat Commun
Ye G, Gao J, Liu X, Zhou Q, Huang L, Cao H, Zhang G, Zhang Z, Liu H, Weng C.   +9 more
europepmc   +1 more source