Results 1 to 10 of about 102,700 (257)

TPR is required for circRNA, lncRNA and mRNA nuclear export [PDF]

Non-coding RNA Research
Background: Efficient RNA nuclear export is essential for proper cellular function and normal physiology, with defects in this process leading to pathological consequences.
Min Zhou, Ruirui Jia, Mengya Gao, Jun Yang, Hongbo Qi   +4 more
doaj   +2 more sources

Lactylation of HMGB1 at K177 Drives Nuclear Export of TIAR to Promote Hypoxia‐Induced Stress Granule Formation [PDF]

Advanced Science
HMGB1, one of the most abundant nuclear non‐histone proteins, also performs extracellular functions, and its nuclear export mechanisms have been extensively studied.
Chengyu Li, Zhaojun Liu, Linjie Zhu, Gang Wu, Chen Fu, Hongmin Li, Tong He, Ming Shen, Honglin Liu   +8 more
doaj   +2 more sources

RANBP3 and RAN orchestrate CRM1-mediated nuclear export of hepatitis B virus RNAs [PDF]

Journal of Virology
Nuclear export of viral RNAs is essential for the replication of hepatitis B virus (HBV). Our previous study demonstrated that ELAVL1 (embryonic lethal, abnormal vision, Drosophila-like 1) mediates the nuclear export of HBV RNAs via the chromosome region
Mengfei Wang, Quan Chen, Yingcheng Zheng, Jiatong Yin, Guoguo Zhu, Kaitao Zhao, Zaichao Xu, Rong Hua, Meng Zhou, Lu Zhang, Gaihong Zhao, Shipeng Yang, Zulihuma Amat, Yuchen Xia, Xiaoming Cheng   +14 more
doaj   +2 more sources

Nuclear export is a limiting factor in eukaryotic mRNA metabolism. [PDF]

PLoS Computational Biology
The eukaryotic mRNA life cycle includes transcription, nuclear mRNA export and degradation. To quantify all these processes simultaneously, we perform thiol-linked alkylation after metabolic labeling of RNA with 4-thiouridine (4sU), followed by ...
Jason M Müller, Katharina Moos, Till Baar, Kerstin C Maier, Kristina Zumer, Achim Tresch   +5 more
doaj   +2 more sources

Involvement of a tick-borne orthomyxovirus matrix protein in vRNP nuclear export [PDF]

Journal of Virology
Thogotoviruses are arthropod-borne viruses belonging to the genus Thogotovirus within the family Orthomyxoviridae. Like other orthomyxoviruses, such as the influenza A viruses (IAV), thogotoviruses replicate in the nucleus.
Vaille A. Swenson, Jack Hemsath, Iris Yousaf, Carla Weisend, Michael A. Barry, Hideki Ebihara, Satoko Yamaoka   +6 more
doaj   +2 more sources

A statistical framework for quantifying the nuclear export rate of influenza viral mRNAs [PDF]

eLife
Influenza A virus transcribes viral mRNAs from the eight segmented viral genome when it infects. The kinetics of viral transcription, nuclear export of viral transcripts, and their potential variation between the eight segments are poorly characterised ...
Michi Miura, Naho Kiuchi, Siu-Ying Lau, Bobo Wing-Yee Mok, Hiroshi Ushirogawa, Tadasuke Naito, Honglin Chen, Mineki Saito   +7 more
doaj   +2 more sources

YTHDC1 phase separation drives the nuclear export of m6A-modified lncNONMMUT062668.2 through the transport complex SRSF3–ALYREF–XPO5 to aggravate pulmonary fibrosis [PDF]

Cell Death and Disease
Fibroblast-to-myofibroblast differentiation is the main cytopathologic characteristic of pulmonary fibrosis. However, its underlying molecular mechanism remains poorly understood.
Shengjun Chen, Yujie Wang, Jinjin Zhang, Bo Liu, Weili Liu, Guohong Cao, Rongrong Li, Hongbo Li, Nailiang Zhai, Xiaodong Song, Songzi Zhang, Changjun Lv   +11 more
doaj   +2 more sources

Data Augmentation of X-ray Images for Automatic Cargo Inspection of Nuclear Items

Sensors, 2023
As part of establishing a management system to prevent the illegal transfer of nuclear items, automatic nuclear item detection technology is required during customs clearance. However, it is challenging to acquire X-ray images of major nuclear items (e.g.
Haneol Jang, Chansuh Lee, Hansol Ko, KyungTae Lim   +3 more
doaj   +1 more source

Dynamics of nuclear export of pre-ribosomal subunits revealed by high-speed single-molecule microscopy in live cells

iScience, 2023
Summary: We present a study on the nuclear export efficiency and time of pre-ribosomal subunits in live mammalian cells, using high-speed single-molecule tracking and single-molecule fluorescence resonance energy transfer techniques.
Samuel L. Junod, Mark Tingey, Joseph M. Kelich, Alexander Goryaynov, Karl Herbine, Weidong Yang   +5 more
doaj   +1 more source

Impaired Nuclear Export of the Ribonucleoprotein Complex and Virus-Induced Cytotoxicity Combine to Restrict Propagation of the A/Duck/Malaysia/02/2001 (H9N2) Virus in Human Airway Cells

Cells, 2020
In humans, (A549) cells impaired H9N2 virus nuclear export of the ribonucleoprotein (RNP) complex contrasted with the early and efficient nuclear export of the H1N1/WSN and pH1N1 virus RNP complexes.
Sriram Kumar, Dawn Yeo, Nisha Harur Muralidharan, Soak Kuan Lai, Cathlyn Tong, Boon Huan Tan, Richard J. Sugrue   +6 more
doaj   +1 more source