An interaction between KSHV ORF57 and UIF provides mRNA-adaptor redundancy in herpesvirus intronless mRNA export. [PDF]
PLoS Pathogens, 2011 The hTREX complex mediates cellular bulk mRNA nuclear export by recruiting the nuclear export factor, TAP, via a direct interaction with the export adaptor, Aly.
Brian R Jackson +9 more
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TPR is required for circRNA, lncRNA and mRNA nuclear export [PDF]
Non-coding RNA ResearchBackground: Efficient RNA nuclear export is essential for proper cellular function and normal physiology, with defects in this process leading to pathological consequences.
Min Zhou +4 more
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Acta Biochimica et Biophysica SinicaIn eukaryotic cells, gene expression begins with transcription in the nucleus, followed by the maturation of messenger RNAs (mRNAs). These mRNA molecules are then exported to the cytoplasm through the nuclear pore ...
Chen Suli +3 more
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Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals
eLife, 2017 Nuclear export receptor CRM1 binds highly variable nuclear export signals (NESs) in hundreds of different cargoes. Previously we have shown that CRM1 binds NESs in both polypeptide orientations (Fung et al., 2015).
Ho Yee Joyce Fung +2 more
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Lactylation of HMGB1 at K177 Drives Nuclear Export of TIAR to Promote Hypoxia‐Induced Stress Granule Formation [PDF]
Advanced ScienceHMGB1, one of the most abundant nuclear non‐histone proteins, also performs extracellular functions, and its nuclear export mechanisms have been extensively studied.
Chengyu Li +8 more
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eEF1A Mediates the Nuclear Export of SNAG-Containing Proteins via the Exportin5-Aminoacyl-tRNA Complex [PDF]
Cell Reports, 2013 Exportin5 mediates the nuclear export of double-stranded RNAs, including pre-microRNAs, adenoviral RNAs, and tRNAs. When tRNAs are aminoacylated, the Exportin5-aminoacyl (aa)-tRNA complex recruits and coexports the translation elongation factor eEF1A ...
José Manuel Mingot +4 more
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Involvement of a tick-borne orthomyxovirus matrix protein in vRNP nuclear export [PDF]
Journal of VirologyThogotoviruses are arthropod-borne viruses belonging to the genus Thogotovirus within the family Orthomyxoviridae. Like other orthomyxoviruses, such as the influenza A viruses (IAV), thogotoviruses replicate in the nucleus.
Vaille A. Swenson +6 more
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Nuclear export is a limiting factor in eukaryotic mRNA metabolism. [PDF]
PLoS Computational BiologyThe eukaryotic mRNA life cycle includes transcription, nuclear mRNA export and degradation. To quantify all these processes simultaneously, we perform thiol-linked alkylation after metabolic labeling of RNA with 4-thiouridine (4sU), followed by ...
Jason M Müller +5 more
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A statistical framework for quantifying the nuclear export rate of influenza viral mRNAs [PDF]
eLifeInfluenza A virus transcribes viral mRNAs from the eight segmented viral genome when it infects. The kinetics of viral transcription, nuclear export of viral transcripts, and their potential variation between the eight segments are poorly characterised ...
Michi Miura +7 more
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Phosphorylation of S‐S‐S Motif in Nuclear Export Protein (NEP) Plays a Critical Role in Viral Ribonucleoprotein (vRNP) Nuclear Export of Influenza A and B Viruses [PDF]
Advanced ScienceThe phosphorylation of three highly conserved serine residues S23, S24, and S25 (S‐S‐S motif) has been previously identified in NEP of influenza virus. However, it remains obscure whether and how this motif regulates the vRNPs nuclear export.
Xiaokun Liu +6 more
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