Results 21 to 30 of about 102,700 (257)
PLoS Pathogens, 2011 The hTREX complex mediates cellular bulk mRNA nuclear export by recruiting the nuclear export factor, TAP, via a direct interaction with the export adaptor, Aly.
Brian R Jackson +9 more
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iScience, 2021 Summary: Heterogeneous nuclear ribonucleoproteins (hnRNPs) play critical roles in the nuclear export, splicing, and sensing of RNA. However, the role of heterogeneous nuclear ribonucleoprotein A/B (hnRNPAB) is poorly understood.
Xingbo Wang +7 more
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Small Molecule Inhibitors of CRM1
Frontiers in Pharmacology, 2020 The transport through the nuclear pore complex is used by cancer cells to evade tumor-suppressive mechanisms. Several tumor-suppressors have been shown to be excluded from the cell nucleus in cancer cells by the nuclear export receptor CRM1 and abnormal ...
Bibiana I. Ferreira +8 more
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Nucleoporin TPR promotes tRNA nuclear export and protein synthesis in lung cancer cells.
PLoS Genetics, 2021 The robust proliferation of cancer cells requires vastly elevated levels of protein synthesis, which relies on a steady supply of aminoacylated tRNAs. Delivery of tRNAs to the cytoplasm is a highly regulated process, but the machinery for tRNA nuclear ...
Miao Chen +8 more
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Spelling out the roles of individual nucleoporins in nuclear export of mRNA
Nucleus, 2022 The Nuclear Pore Complex (NPC) represents a critical passage through the nuclear envelope for nuclear import and export that impacts nearly every cellular process at some level.
Mark Tingey +4 more
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Journal of Cell Science, 2003 Eukaryotic cells export several different classes of RNA molecule from the nucleus, where they are transcribed, to the cytoplasm, where the majority participate in different aspects of protein synthesis. It is now clear that these different classes of RNA, including rRNAs, tRNAs, mRNAs and snRNAs, are specifically directed into distinct but in some ...
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Regulation of Stat3 nuclear export [PDF]
Journal of Clinical Investigation, 2003 Stat3 is the most pleiotropic member of the signal transducer and activator of transcription (STAT) family of transcription factors and mediates pivotal responses for the cytokine family. In resting cells, STATs, including Stat3, reside largely in the cytoplasm.
Samita, Bhattacharya +1 more
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Nucleocytoplasmic shuttling activity of ataxin-3. [PDF]
PLoS ONE, 2009 Spinocerebellar ataxia type-3, also known as Machado-Joseph Disease (MJD), is one of many inherited neurodegenerative disorders caused by polyglutamine-encoding CAG repeat expansions in otherwise unrelated genes.
Sandra Macedo-Ribeiro +3 more
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Nuclear export, enlightened [PDF]
Proceedings of the National Academy of Sciences, 2012 The physicist Richard Feynman once quipped that the key to solving or making significant progress on a scientific problem was to “find the open channel.” For the cell biological problem of nucleus-to-cytoplasm transport, the literal open channels have long been known: the nuclear pore complexes (NPCs). However, in the metaphorical sense as well, recent
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Journal of Lipid Research, 2009 CTP:phosphocholine cytidylyltransferase α (CCTα), the rate-limiting enzyme in the CDP-choline pathway for phosphatidylcholine (PtdCho) synthesis, is activated by translocation to nuclear membranes.
Karsten Gehrig +2 more
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