Results 1 to 10 of about 110,633 (258)
RNA Export through the NPC in Eukaryotes [PDF]
Genes, 2015 In eukaryotic cells, RNAs are transcribed in the nucleus and exported to the cytoplasm through the nuclear pore complex. The RNA molecules that are exported from the nucleus into the cytoplasm include messenger RNAs (mRNAs), ribosomal RNAs (rRNAs), transfer RNAs (tRNAs), small nuclear RNAs (snRNAs), micro RNAs (miRNAs), and viral mRNAs.
Seiji Masuda, Masuda Seiji
exaly +5 more sources
RNA export through the nuclear pore complex is directional [PDF]
Nature Communications, 2022 There is little information on export directionality of RNA passing through the nuclear pore complex in human cells. Here, the authors examine single RNA molecules in transit, to demonstrate 5’-first directionality for the export of mRNA and lncRNA.
Asaf Ashkenazy-Titelman +4 more
doaj +2 more sources
The RNA export factor TbMex67 connects transcription and RNA export in Trypanosoma brucei and sets boundaries for RNA polymerase I. [PDF]
Nucleic Acids Res, 2023 Abstract TbMex67 is the major mRNA export factor known to date in trypanosomes, forming part of the docking platform within the nuclear pore. To explore its role in co-transcriptional mRNA export, recently reported in Trypanosoma brucei, pulse labelling of nascent RNAs with 5-ethynyl uridine (5-EU) was performed with cells depleted of ...
Pozzi B +4 more
europepmc +3 more sources
RNA export through the nuclear pore complex: pathways, mechanisms, and imaging strategies [PDF]
RNA BiologyUnderstanding how RNA molecules traverse the nuclear pore complex (NPC) is central to regulated gene expression because the NPC serves as the selective gateway for RNA export from the nucleus.
Donghong Fu +5 more
doaj +2 more sources
RANBP3 and RAN orchestrate CRM1-mediated nuclear export of hepatitis B virus RNAs [PDF]
Journal of VirologyNuclear export of viral RNAs is essential for the replication of hepatitis B virus (HBV). Our previous study demonstrated that ELAVL1 (embryonic lethal, abnormal vision, Drosophila-like 1) mediates the nuclear export of HBV RNAs via the chromosome region
Mengfei Wang +14 more
doaj +2 more sources
Engineering RNA export for measurement and manipulation of living cells [PDF]
Cell, 2023 Felix Horns +2 more
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Regulation of the export of RNA from the nucleus
Seminars in Cell and Developmental Biology, 1997 Transport of macromolecules across the nuclear envelope is an essential activity in eukaryotic cells. RNA molecules within cells are found complexed with proteins and the bound proteins likely contain signals for RNA export. RNAs microinjected into Xenopus oocyte nuclei are readily exported, and their export can be competed by self RNA but not by RNAs ...
C N Cole, Charles N Cole
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Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export [PDF]
EMBO Journal, 1998 The DBP5 gene encodes a putative RNA helicase of unknown function in the yeast Saccharomyces cerevisiae. It is shown here that Dbp5p is an ATP-dependent RNA helicase required for polyadenylated [poly(A)+] RNA export. Surprisingly, Dbp5p is present predominantly, if not exclusively, in the cytoplasm, and is highly enriched around the nuclear envelope ...
Tien-Hsien Chang +2 more
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Molecular insights into mRNA export regulation by the human TREX-2 complex [PDF]
Nature CommunicationsThe nuclear export of mRNA represents a critical regulatory node in eukaryotic gene expression. This process is orchestrated by two conserved multi-subunit assemblies: the transcription-and-export complex (TREX) and TREX-2.
Xing Gong +8 more
doaj +2 more sources
Channel nuclear pore complex subunits are required for transposon silencing in Drosophila
eLife, 2021 The nuclear pore complex (NPC) is the principal gateway between nucleus and cytoplasm that enables exchange of macromolecular cargo. Composed of multiple copies of ~30 different nucleoporins (Nups), the NPC acts as a selective portal, interacting with ...
Marzia Munafò +8 more
doaj +1 more source